Organizing co mmittee

References: 
1. Khanin V.A., Moiseev O.O., Babkina A.Y., Kotenko O.M., Kotov A.G. 
News of 
Pharmacy
. 2016, V. 86, pp. 24-27. https://doi.org/10.24959/nphj.16.2126 
2. Haupt, O., Tchoukouegno Ngueu, S., Diel, P., Parr, M. Cologne: Sport und 
BuchStrauß; 2012. 

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Poster presentation 
313 
RESULTS OF PHARMACOLOGICAL STUDIES OF FERULA 
TADSHIKORUM RESIN OF FLORA OF UZBEKISTAN 
Egamova F.R., Mirzaev Yu.R., Ruzimov E.M., Aripova S.F., Khalilova E.Kh. 
Institute of Chemistry of Plant Substances named after acad. S.Yu.Yunusov Academy 
of Sciences of the Republic of Uzbekistan, Tashkent 100170, Uzbekistan, e-mail: 
[e-mail] 
Ferula tadshikorum
resin obtained by cutting the lower part of the trunk in early 
spring is used as a seasoning for food in the Orient. Currently, tons of resin are exported 
to the Middle East and South Asia. 
In folk medicine of the East, the use of 
F. tadshikorum
is known as an antiparasitic, 
anticonvulsant, antispasmodic, expectorant, for tuberculosis, malignant tumors and to 
improve digestion. The dried juice of the plant consists of resin, gum and essential oil. 
Ferulic acid, asarezinotanol, assarezinol and their ferule derivatives: farnesiferol C, 
umbelliferon et al. isolated from the resin. 
We have studied 3 different fractions obtained from the resin of this plant collected 
in the Kashkadarya region of Uzbekistan: alcohol, gasoline and chloroform. The 
pharmacological properties of the 3 fractions were investigated using various 
experiments on laboratory animals. 
As a result of the study, it was found that the alcohol fraction at a dose of 10 mg/kg 
obtained from this plant has a more pronounced pharmacological effect than the other 
two fractions. 
In a model of indomethacin gastric ulcer (30 mg/kg) orally, 16.0±3.4 drain ulcers 
were detected in control mice. Against the background of alcohol fraction treatment, the 
number of ulcers was - 8.0±2.8 (p<0.05), i.e. reduced the number of ulcers twice. 
The effect of alcohol fraction on intestinal motility of intact mice was studied. In the 
control group, for 4 hours, the number of boluses was 25.0±2.3, against the background 
of the alcohol fraction, the number of boluses decreased by 19.0±2.0, i.e. 24%. 
Thus, the conducted studies revealed that the alcohol fraction of 
Ferula tadshikorum 
significantly showed an anti-ulcer effect. The study of the effect on intestinal motility 
has shown its certain oppression.