Microsoft Word search phase 3 Title Page Amendment

2.
 
DESCRIPTION OF STUDY CENTERS AND POPULATIONS .................................... 1
 
2.1.
 
OHIO
 
-
 
CINCINNATI
 
CHILDREN’S
 
HOSPITAL
 
MEDICAL
 
CENTER .................... 1
 
2.2.
 
COLORADO
 
-
 
UNIVERSITY
 
OF
 
COLORADO
 
DENVER
 
CENTER ......................... 2
 
2.3.
 
WASHINGTON
 
-
 
SEATTLE
 
CHILDREN’S
 
RESEARCH
 
INSTITUTE ......................  2
 
2.4.
 
CAROLINAS
 
CENTER ................................................................................................. 3
 
2.5.
 
CALIFORNIA
 
-
 
KAISER
 
PERMANENTE
 
SOUTHERN
 
CALIFORNIA .................... 4
 
 

---

Section 2 - Center Descriptions (Phase 3 - 12/2010) 
Section 2 - Page 1 
2.
 
Description of Study Centers and Populations 
SEARCH Phase 3 has five centers, located in Ohio, Colorado, Washington, South Carolina, 
and California.  
Four SEARCH centers (Ohio, Colorado, Washington, and South Carolina) are 
geographically based - that is, newly diagnosed diabetes cases will be identified from a 
geographically defined population.  One SEARCH center (California) is membership-based - 
that is, diabetes cases will be identified among members of the participating health plans. 
Each of the five centers will be participating in both the Registry component and the Cohort 
component of SEARCH Phase 3.  The Registry component will include incident cases in 
defined populations areas from 2010 - 2014.  The Cohort component will include follow-up 
visits with incident cases with at least five years duration of diabetes from SEARCH Phases 
1 and 2 belonging to the incident 2002-2006 and 2008 cohorts. 
The following is a description of each study center, its case finding approaches, approach to 
denominator estimation, and study population characteristics.  Further details on denominator 
estimation and case finding approaches are in Section 5. 
2.1.
 
OHIO - CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER 
The Cincinnati center is located in Cincinnati, Ohio at Children’s Hospital Medical Center.  
Children with diabetes who reside in Cincinnati and the eight metropolitan counties that 
surround Cincinnati will be identified and invited to participate. 
Children’s Hospital, established in 1883, is the only pediatric facility serving southwest 
Ohio, northern Kentucky, and southwest Indiana.  As a result children and youth with 
complex medical problems are referred to Children’s Hospital.  The diabetes team, 
established in 1978, provides care and education for pediatric diabetes patients in the greater 
Cincinnati area.  In 1988, a computer database containing demographic and other data on all 
patients diagnosed with diabetes since 1978 was established.  The database is updated daily 
with prospectively collected information on newly diagnosed patients with childhood 
diabetes.  For SEARCH, the Cincinnati center will use the information in this computer 
database to identify cases. 
Although a majority of the care and management of childhood diabetes is provided at 
Children’s Hospital, in order to insure complete ascertainment the investigators have 
established a network of physicians, health care workers and educators that identifies, 
contacts, and collects data from the small number of patients with childhood diabetes who 
are not diagnosed at Children’s Hospital.  
The Cincinnati center will use the U.S. census as the source of denominator estimates. 

---

Section 2 - Center Descriptions (Phase 3 - 12/2010) 
Section 2 - Page 2 
In 2000, approximately 550,000 children and youth less than 20 years of age resided in the 
eight counties surrounding Cincinnati, including about 15% of a non-white racial/ethnic 
background 
2.2.
 
COLORADO - UNIVERSITY OF COLORADO DENVER CENTER 
The population under surveillance at the Colorado SEARCH center consists of all youth age 
<20 years a) residing in the state of Colorado (64 counties) in 2010-2014, or b) members of 
the Navajo Indian tribe in Arizona, Utah and New Mexico residing on the Navajo Nation 
reservation.  The estimated total population under surveillance at the Colorado SEARCH 
center is ~1.4 million youth age < 20 years. 
The study is conducted by the University of Colorado Denver, Colorado School of Public 
Health Department of Epidemiology, through close collaboration with two major pediatric 
endocrinology units serving both metropolitan and remote areas: the Barbara Davis Center 
for Childhood Diabetes and the Pediatric Endocrine Associates.  In addition, the availability 
of computerized databases at large community health centers and the collaboration of major 
hospital systems provide a nearly complete and very efficient ascertainment network.  
In the first 10 years of the study, this center has established close and trusting partnerships 
with the Navajo Indian tribe.  The study is conducted in the Navajo Nation through a