Российское общество дерматовенерологов и косметологов федеральные клинические рекомендации по ведению больных псориазом

111. Gelfand JM, Troxel AB, Lewis JD, Kurd SK, Shin DB, WangX, et al. The risk of mortality in patients with psoriasis: results from a population-based study. Arch Dermatol 2007;143:1493-9.

112. Gollnick HP. Oral retinoidseefficacy and toxicity in psoriasis. Br J Dermatol 1996;135(Suppl):6-17.

113. Griffiths CE, Dubertret L, Ellis CN, Finlay AY, Finzi AF, Ho VC, et al. Cyclosporin in psoriasis clinical practice: an international consensus statement. Br J Dermatol 2004;150(Suppl): 11-23.

114. Paul CF, Ho VC, McGeown C, Christophers E, Schmidtmann B, Guillaume JC, et al. Risk of malignancies in psoriasis patients treated with cyclosporine: a 5 y cohort study. J Invest Dermatol 2003;120:211-6.

115. Miele L, Vallone S, Cefalo C, La Torre G, Di Stasi C, Vecchio FM, et al. Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 2009;51:778-86.

116. Pollono EN, Lopez-Olivo MA, Lopez JA, Suarez-Almazor ME. A systematic review of the effect of TNF-alpha antagonists on lipid profiles in patients with rheumatoid arthritis. Clin Rheumatol 2010;29:947-55.

117. Menter A, Feldman SR, Weinstein GD, Papp K, Evans R, Guzzo C, et al. A randomized comparison of continuous vs intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis. J Am Acad Dermatol 2007;56:31, e1-15.

118. Massarotti M, Marasini B. Successful treatment with etanercept of a patient with psoriatic arthritis after adalimumabrelated hepatotoxicity. Int J Immunopathol Pharmacol 2009; 22:547-9.

119. Reich K, Nestle FO, Papp K, Ortonne JP, Evans R, Guzzo C, et al. Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicenter, double-blind trial. Lancet 2005;366:1367-74.

120. Comte C, Guilhou JJ, Guillot B, Dereure O. Rapid onset and fatal outcome of two squamous cell carcinomas of the genitalia in a patient treated with etanercept for cutaneous psoriasis. Dermatology 2008;217:284-5.

121. Ly L, Czarnecki D. The rapid onset of multiple squamous cell carcinomas during etanercept treatment for psoriasis. Br J Dermatol 2007;157:1076-8.

122. Fryrear RS II, Wiggins AK, Sangueza O, Yosipovitch G. Rapid onset of cutaneous squamous cell carcinoma of the penis in a patient with psoriasis on etanercept therapy. J Am AcadDermatol 2004;51:1026.

123. Wolfe F, Michaud K. Biologic treatment of rheumatoidarthritis and the risk of malignancy: analyses from a large US observational study. Arthritis Rheum 2007;56:2886-95.

124. Jacobsson LT, Turesson C, Nilsson JA, Petersson IF, Lindqvist E, Saxne T, et al. Treatment with TNF blockers and mortality risk in patients with rheumatoid arthritis. Ann Rheum Dis 2007;66:670-5.

125. Paller AS, Siegfried EC, Langley RG, Gottlieb AB, Pariser D, Landells I, et al. Etanercept treatment for children and adolescents with plaque psoriasis. N Engl J Med 2008;358:241-51.

126. Clark L, Lebwohl M. The effect of weight on the efficacy ofbiologic therapy in patients with psoriasis. J Am Acad Dermatol 2008;58:443-6.

127. Menter A, Gordon KB, Leonardi CL, Gu Y, Goldblum OM. Efficacy and safety of adalimumab across subgroups of patients with moderate to severe psoriasis. J Am Acad Dermatol 2010;63:448-56.

128. Carter JD, Ladhani A, Ricca LR, Valeriano J, Vasey FB. A safety assessment of tumor necrosis factor antagonists during pregnancy: a review of the Food and Drug Administration database. J Rheumatol 2009;36:635-41.

129. Rosenbach M, Hsu S, KormanNJ Lebwohl MG, Young M, Bebo BF Jr, et al. Treatment of erythrodermic psoriasis: from the medical board of the National Psoriasis Foundation. J Am Acad Dermatol 2010;62:655-62.

130. Boyd AS, Menter A. Erythrodermic psoriasis: precipitating factors, course, and prognosis in 50 patients. J Am Acad Dermatol 1989;21:985-91.

131. Studio Italiano Multicentrico nella Psoriasi (SIMPSO). Management of erythrodermic psoriasis with low-dose cyclosporin. Dermatology 1993;187(Suppl):30-7.

132. Morris LF, Harrod MJ, Menter MA, Silverman AK. Methotrexate and reproduction in men: case report and recommendations. J Am Acad Dermatol 1993;29:913-6.

133. Richetta AG, Maiani E, Carlomagno V, Carboni V, Mattozzi C, Giancristoforo S, et al. Treatment of erythrodermic psoriasis in HCV1 patient with adalimumab. Dermatol Ther 2009;22 (Suppl):S16-8.

134. Santos-Juanes J, Coto-Segura P, Mas-Vidal A, Galache Osuna C. Ustekinumab induces rapid clearing of erythrodermic psoriasis after failure of antitumor necrosis factor therapies. Br J Dermatol 2010;162:1144-6.

135. Hearn RM, Kerr AC, Rahim KF, Ferguson J, Dawe RS. Incidence

of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy. Br J Dermatol 2008;159:931-5.

136. Paul BS, Momtaz K, Stern RS, Arndt KA, Parrish JA. Combined methotrexateeultraviolet B therapy in the treatment of psoriasis. J Am Acad Dermatol 1982;7:758-62.

137. Asawanonda P, Nateetongrungsak Y. Methotrexate plus narrowband UVB phototherapy versus narrowband UVB phototherapy alone in the treatment of plaque-type psoriasis: a randomized, placebo-controlled study. J Am Acad Dermatol 2006;54:1013-8.

138. Morison WL, Momtaz K, Parrish JA, Fitzpatrick TB. Combined methotrexate-PUVA therapy in the treatment of psoriasis. J Am Acad Dermatol 1982;6:46-51.

139. Nijsten TE, Stern RS. Oral retinoid use reduces cutaneous squamous cell carcinoma risk in patients with psoriasis treated with psoralen-UVA: a nested cohort study. J Am Acad Dermatol 2003;49:644-50.

140. Kircik L, Bagel J, Korman N, Menter A, Elmets CA, Koo J, et al. Utilization of narrow-band ultraviolet light B therapy and etanercept for the treatment of psoriasis (UNITE): efficacy, safety, and patient-reported outcomes. J Drugs Dermatol 2008;7:245-53.

141. Ortonne JP, Khemis A, Koo JY, Choi J. An open-label study of alefacept plus ultraviolet B light as combination therapy for chronic plaque psoriasis. J Eur Acad Dermatol Venereol 2005; 19:556-63.

142. Legat FJ, Hofer A, Wackernagel A, Salmhofer W, Quehenberger F, Kerl H, et al. Narrowband UV-B phototherapy, alefacept, and clearance of psoriasis. Arch Dermatol 2007; 143:1016-22.

143. Edmundson WF, Guy WB. Treatment of psoriasis with folic acid antagonists. AMA Arch Derm 1958;78:200-3.

144. Van Dooren-Greebe RJ, Kuijpers AL, Mulder J, De Boo T, Van de Kerkhof PC. Methotrexate revisited: effects of long-term treatment in psoriasis. Br J Dermatol 1994;130: 204-10.

145. Kalb RE, Strober B, Weinstein G, Lebwohl M. Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. J Am Acad Dermatol 2009;60:824-37.

146. Rosenberg P, Urwitz H, Johannesson A, Ros AM, Lindholm J, Kinnman N, et al. Psoriasis patients with diabetes type 2 are at high risk of developing liver fibrosis during methotrexate treatment. J Hepatol 2007;46:1111-8.

147. Aithal GP. Dangerous liaisons: drug, host and the environment. J Hepatol 2007;46:995-8.

148. Chalmers RJ, Kirby B, Smith A, Burrows P, Little R, Horan M, et al. Replacement of routine liver biopsy by procollagen III aminopeptide for monitoring patients with psoriasis receiving long-term methotrexate: a multicenter audit and health economic analysis. Br J Dermatol 2005;152:444-50.

149. Amor K, Ryan C, Menter A. The use of cyclosporine in dermatology: part I. J Am Acad Dermatol 2010;63:925-46.

150. Ryan C, Amor K, Menter A. The use of cyclosporine in dermatology: part II. J Am Acad Dermatol 2010;63:949-72.

151. Timonen P, Friend D, Abeywickrama K, Laburte C, von Graffenried B, Feutren G. Efficacy of low-dose cyclosporine A in psoriasis: results of dose-finding studies. Br J Dermatol 1990;122(Suppl):33-9.

152. Faerber L, Braeutigam M, Weidinger G, Mrowietz U, Christophers E, Schulze HJ, et al. Cyclosporine in severe psoriasis: results of a meta-analysis in 579 patients. Am J Clin Dermatol 2001;2:41-7.

153. Ozawa A, Ohkido M, Haruki Y, Kobayashi H, Ohkawara A, Ohno Y, et al. Treatments of generalized pustular psoriasis: a multicenter study in Japan. J Dermatol 1999;26:141-9.

154. Buccheri L, Katchen BR, Karter AJ, Cohen SR. Acitretin therapy is effective for psoriasis associated with human immunodeficiency virus infection. Arch Dermatol 1997;133:711-5.

155. Vahlquist A. Long-term safety of retinoid therapy. J Am Acad Dermatol 1992;27(Suppl):S29-33.

156. DiGiovanna JJ, Sollitto RB, Abangan DL, Steinberg SM, Reynolds JC. Osteoporosis is a toxic effect of long-term etretinate therapy. Arch Dermatol 1995;131:1263-7.

157. Gordon KB, Vaishnaw AK, O’Gorman J, Haney J, Menter A. Treatment of psoriasis with alefacept: correlation of clinical improvement with reductions of memory T-cell counts. Arch Dermatol 2003;139:1563-70.

158. Suarez-Farinas M, Shah KR. HaiderAS, Krueger JG, Lowes MA. Personalized medicine in psoriasis: developing a genomic classifier to predict histological response to alefacept. BMC Dermatol 2010;10:1.

159. Pink AE, Fonia A, Allen MH, Smith CH, Barker JN. Antinuclear antibodies associate with loss of response to antitumor necrosis factor-alpha therapy in psoriasis: a retrospective, observational study. Br J Dermatol 2010; 162:780-5.

160. Wallis RS, Broder MS, Wong JY, Hanson ME, Beenhouwer DO. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin Infect Dis 2004;38: 1261-5.

161. Langley RG, Strober BE, Gu Y, Rozzo SJ, Okun MM. Benefit-risk assessment of tumor necrosis factor antagonists in the treatment of psoriasis. Br J Dermatol 2010;62:1349-58.

162. Gordon K, Leonardi C, Lebwohl M. The ustekinumab safety experience in patients with moderate-to-severe psoriasis: results from pooled analyses of phase 2 and phase 3 clinical trial data. Poster P 1170 presented at European Academy of Dermatology and Venereology Annual Congress; October 7-11, 2009; Berlin, Germany.

163. Aydin F, Canturk T, Senturk N, Turanli AY. Methotrexate and cyclosporin combination for the treatment of severe psoriasis. Clin Exp Dermatol 2006;31:520-4.

164. Clark CM, Kirby B, Morris AD, Davison S, Zaki I, Emerson R, et al. Combination treatment with methotrexate and cyclosporine for severe recalcitrant psoriasis. Br J Dermatol 1999; 141:279-82.

165. Lowenthal KE, Horn PJ, Kalb RE. Concurrent use of methotrexate and acitretin revisited. J Dermatolog Treat 2008;19: 22-6.

166. Cather JC, Menter A. Combining traditional agents and biologics for the treatment of psoriasis. Semin Cutan Med Surg 2005;24:37-45.

167. Yamauchi PS, Lowe NJ. Etanercept therapy allows the tapering of methotrexate and sustained clinical responses in patients with moderate to severe psoriasis. Int J Dermatol 2008;47:202-4.

168. Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, Macfarlane JD, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41:1552-63.

169. Atzeni F, Sarzi-Puttini P. Autoantibody production in patients treated with anti-TNF-alpha. Expert Rev Clin Immunol 2008;4: 275-80.

170. Hamilton TK. Treatment of psoriatic arthritis and recalcitrant skin disease with combination therapy. J Drugs Dermatol 2008;7:1089-93.

171. Robinson MR, Korman BD, Korman NJ. Combination immunosuppressive

therapies: the promise and the peril. Arch Dermatol 2007;143:1053-7.

172. Griffiths CE, Powles AV, McFadden J, Baker BS, Valdimarsson H, Fry L. Long-term cyclosporin for psoriasis. Br J Dermatol 1989;120:253-60.

173. Gottlieb SL, Heftler NS, Gilleaudeau P, Johnson R, Vallat VP, Wolfe J, et al. Short-contact anthralin treatment augmentstherapeutic efficacy of cyclosporine in psoriasis: a clinical and

pathologic study. J Am Acad Dermatol 1995;33:637-45.

174. Grossman RM, Thivolet J, Claudy A, Souteyrand P, Guilhou JJ, Thomas P, et al. A novel therapeutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporine: results of a multicenter placebo-controlled study. J Am Acad Dermatol 1994;31:68-74.

175. Ameen M, Smith HR, Barker JN. Combined mycophenolate mofetil and cyclosporin therapy for severe recalcitrant psoriasis. Clin Exp Dermatol 2001;26:480-3.

176. Griffiths CE, Finlay AY, Fleming CJ, Barker JN, Mizzi F, Arsonnaud S. A randomized, investigator-masked clinical evaluation of the efficacy and safety of clobetasol propionate 0.05% shampoo and tar blend 1% shampoo in the treatment of moderate to severe scalp psoriasis. J Dermatolog Treat 2006; 17: 90-95.

177. Weinstein GD, White GM. An approach to the treatment of moderate to severe psoriasis with rotational therapy. J Am Acad Dermatol 1993;28:454-9.

178. Menter MA, See JA, Amend WJ, Ellis CN, Krueger GG, Lebwohl M, et al. Proceedings of the Psoriasis Combination and Rotation Therapy Conference; Deer Valley, Utah; Oct 7-9, 1994. J Am Acad Dermatol 1996;34:315-21.

179. Saurat JH, Stingl G, Dubertret L, Papp K, Langley RG, Ortonne JP, et al. Efficacy and safety results from the randomized controlled comparative study of adalimumab vs methotrexate vs placebo in patients with psoriasis (CHAMPION). Br J Dermatol 2008;158:558-66.

180. Griffiths CE, Strober BE, van de Kerkhof P, Ho V, Fidelus-Gort R, Yeilding N, et al. Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med 2010;362:118-28.

181. Heydendael VM, Spuls PI, Opmeer BC, de Borgie CA, Reitsma JB, Goldschmidt WF, et al. Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis. N Engl J Med 2003;349:658-65.

182. Flytstrom I, Stenberg B, Svensson A, Bergbrant IM. Methotrexate vs cyclosporin in psoriasis: effectiveness, quality of life and safety; a randomized controlled trial. Br J Dermatol 2008; 158:116-21.

183. Mahrle G, Schulze HJ, Farber L, Weidinger G, Steigleder GK. Low-dose short-term cyclosporine versus etretinate in psoriasis: improvement of skin, nail, and joint involvement. J Am Acad Dermatol 1995;32:78-88.

184. Kane D, Stafford L, Bresnihan B, FitzGerald O. A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experience. Rheumatology (Oxford) 2003;42:1460-8.

185. Gottlieb AB,Mease PJ,Mark Jackson J, Eisen D,Amy Xia H, Asare C, et al. Clinical characteristics of psoriatic arthritis and psoriasis in dermatologists’ offices. J Dermatolog Treat 2006;17:279-87.

186. Shbeeb M, Uramoto KM, Gibson LE, O’Fallon WM, Gabriel SE. The epidemiology of psoriatic arthritis in Olmsted County, Minnesota, USA, 1982-1991. J Rheumatol 2000;27:1247-50.

187. Fraser AD, van Kuijk AW, Westhovens R, Karim Z, Wakefield R, Gerards AH, et al. A randomized, double blind, placebo controlled, multicenter trial of combination therapy with methotrexate plus cyclosporin in patients with active psoriatic arthritis. Ann Rheum Dis 2005;64:859-64.

188. Gottlieb A, Menter A, Mendelsohn A, ShenYK Li S, Guzzo C, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomized, double-blind, placebo-controlled, crossover trial. Lancet 2009;373:633-40.

189. Heiberg MS, Kaufmann C, Rodevand E, Mikkelsen K, Koldingsnes W, Mowinckel P, et al. The comparative effectiveness of anti-TNF therapy and methotrexate in patients with psoriatic arthritis: 6 month results from a longitudinal, observational, multicenter study. Ann Rheum Dis 2007;66: 1038-42.

190. Gladman DD, Mease PJ, Choy EH, Ritchlin CT, Perdok RJ, Sasso EH. Risk factors for radiographic progression in psoriatic arthritis: subanalysis of the randomized controlled trial ADEPT. Arthritis Res Ther 2010;12:R113.

191. Farber EM, Nall ML. The natural history of psoriasis in 5,600 patients. Dermatologica 1974;148:1-18.

192. Christensen TE, Callis KP, Papenfuss J, Hoffman MS, Hansen CB, Wong B, et al. Observations of psoriasis in the absence of therapeutic intervention identifies two unappreciated morphologic variants, thin-plaque and thick-plaque psoriasis, and their associated phenotypes. J Invest Dermatol 2006;126: 2397-403.

193. Ben-David G, Sheiner E, Hallak M, Levy A. Pregnancy outcome in women with psoriasis. J Reprod Med 2008;53:183-7.

194. Horn EJ, Chambers CD, Menter A, Kimball AB. Pregnancy outcomes in psoriasis: why do we know so little? J Am Acad Dermatol 2009;61:e5-8.

195. Griffiths CE. Management of psoriasis in pregnancy: time to deliver? Br J Dermatol 2010;163:235.

196. Prodanovich S, Ma F, Taylor JR, Pezon C, Fasihi T, Kirsner RS. Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis. J Am Acad Dermatol 2005;52:262-7.

197. Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M. Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 2006;298:321-8.

198. Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, et al. Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol 2010;130: 1213-26.

199. Griffiths CE. Psoriasis: future research needs and goals for the twenty-first century. Dermatol Clin 2004;22:493-9.

200. Ryan C, Menter A, Warren RB. The latest advances in pharmacogenetics and pharmacogenomics in the treatment of psoriasis. Mol Diagn Ther 2010;14:81-93.

201. Wolfram JA, Diaconu D, Hatala DA, Rastegar J, Knutsen DA, Lowther A, et al. Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis. Am J Pathol 2009;174:1443-58.

202. Buckley, C. et al. Mortality in psoriatic arthritis—a single-center study from the

UK. J. Rheumatol. 37, 2141–2144 (2010).

203. Gladman, D. D. Mortality in psoriatic arthritis. Clin. Exp. Rheumatol. 26 (Suupl.51), S62–S65, (2008).

204. Raychaudhuri SK, Chatterjee S, Nguyen C, et al. Increased prevalence of the

metabolic syndrome in patients with psoriatic arthritis. Metab Syndr Relat Disord 2010;8:331–4.

205. Jashin J. Wu, Kwun-Yee T. Poon, Jennifer C. Channual, Albert Yuh-Jer Shen.

Association Between Tumor Necrosis Factor Inhibitor Therapy and Myocardial Infarction Risk in Patients With Psoriasis Arch Dermatol. Published online August 20, 2012.

206. McInnes IB, Kavanaugh A, Gottlieb AB, Puig L, Rahman P, Ritchlin C, Brodmerkel C, Li S, Wang Y, Mendelsohn AM, Doyle MK; PSUMMIT 1 Study Group. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet. 2013 Aug 31;382(9894):780-9.

207. Kimball AB, Papp KA, Wasfi Y, Chan D, Bissonnette R, Sofen H, Yeilding N, Li S, Szapary P, Gordon KB; on behalf of the PHOENIX 1 investigators. Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years in the PHOENIX 1 study. J Eur Acad Dermatol Venereol. 2012 Dec 20.

208. Papp KA, Griffiths CE, Gordon K, Lebwohl M, Szapary PO, Wasfi Y, Chan D, Hsu MC, Ho V, Ghislain PD, Strober B, Reich K; PHOENIX 1 Investigators; PHOENIX 2 Investigators; ACCEPT Investigators. Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up. Br J Dermatol. 2013 Apr;168(4):844-54.

209. Sieper J., Van der Heijde D., Landewe R. et al. New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of SpondyloArthritis International Society (ASAS). Ann. Rheum. Dis. 2009, 68.784–748.

210. Soriano E., McHugh N. Therapies for peripheral joint disease in psoriatic arthritis. A systematic Review. J Rheum 2006,33,1-7 . 211. Eder L, Chandran V, Ueng J, et al. Predictors of response to intra-articular steroid injection in psoriatic arthritis. Rheumatology (Oxford). 2010;49(7):1367-73.

211. Kavanaugh A., Ritchlin C. Systematic review of treatments for psoriatic arthritis: an evidence based approach for treatment guidelines. J. Rheumatol. 2006. 33; 7 : 1417-21.

212. Van Dooren-Greebe R.J., Kupers A.L., Mulder J. et al. Methotrexate revised: effects of long-term treatment in psoriasis. Br. J. Dermatol. 1994; 130: 204-10.

213. Flytstrom I., Stenberg B., Svensson A., Bergbrant I.M. Methotrexate vs Cyclosporine in psoriasis: effectiveness, quality of life and safety. Br. J. Dermatol. 2008, 158, 116-21

214. Fraser AD, van Kuijk AWR, Westhovens R, et al. A randomized, double blind,

placebo controlled multicentre trial of combination therapy with methotrexate plus cyclosporine in patients with active psoriatic arthritis.Ann Rheum Dis 2005,64,859–64.

215. Zachariae H., Zachariae E. Methotrexate treatment of psoriatic arthritis. Acta

Derm Venerol 1987;67:270-3.

216. Espinoza L.R., Zakraoui L., Espinoza L. R. Psoriatic arthritis: clinical response

and side effects to Methotrexate therapy. J Rheum 1992;19:872-7.

217. Abu-Shakra M., Gladman D. D., Thorne J.C., et al. Longterm methotrexate

therapy in psoriatic arthritis: clinical and radiological outcome. J Rheum 1995;22:241-5.

218. Salvarani C., Macchioni P., Olivieri I., et al. A Comparison of cyclosporine,

sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. J Rheum

2001;28:2274-82.

219. Haibel H. Six months open label trial of leflunomide in active ankylosing

spondylitis. Ann Clin. Rheum Dis 2005; 64: 124-6.

220. Van Denderen JC. Double blind, randomised, placebo controlled study of

leflunomide in the treatment of active ankylosing spondylitis. Ann Rheum Dis 2005; 64 (12):1761-4

221. Cuchacovich M., Soto L. Leflunomide decreases joint erosion and induces

reparative changes in a patients with psoriatic arthritis. Ann Rheum Dis 2001; 60: 913-23.

222. Kaltwasser J.P., Nash P., Gladman D.D., et al. Treatment of psoriatic arthritis

study group. Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: A multionational, double-blind, randomized, placebo – controlled clinical trial. Arthr Rheum 2004; 50: 1939-50.

223. Sparado A., Riccieri V, Sili-Scavalli A., et al. A Comparison of cyclosporine and

methotrexate in the treatment of psoriatic arthritis: a one – year prospective study. Clin Exp Rheum 1995;13:589-9363.

224. McHuge N., Van der Bosch F., Roedevand E. et al. Effective treatment for joint and skin symptoms with Adalimumab in combination with various DMARDs in patients with psoriatic arthritis: results of the STEREO trial. 26th Annual General Meeting of the British Society for Rhe OP 21, 2009.

225. Yang H, Epstein D, Bojke L et al. Golimumab for the treatment of psoriatic arthritis // Health Technol Assess. 2011 May;15 Suppl 1:87-95.

226. Kay J, Matteson EL, Dasgupta B, Nash P, Durez P, Hall S, et al. Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: a randomized, double-blind, placebocontrolled, dose-ranging study. Arthritis Rheum 2008;58:964–75.