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Conclusion
The issue of reperfusion injury occurring in the small intestine after its strangulation is crucial. The optimal solution of the problem, apparently, may be a clinical use of medicinal preparations with a potent antioxidant effect. The presented study supports the concept of using peroxiredoxins as a basis for pharmacological agents aimed at recovery of a redox status in a damaged tissue. Furthermore, the obtained results may be applicable in modifying the perfusion media used for preservation of isolated organs prior to their transplantation. A pre-transplantation reperfusion of isolated organs with peroxiredoxin-containing media can significantly improve the antioxidant status of the organ that would result in a reduced severity of the subsequent I/R injury to the organ after transplantation. Further studies of these issues are necessary.
This work was supported by the Russian Foundation for Basic Research (RFBR) Grants 13-04-00537, 13-04-00763 and by the RAS Presidium Grant on "Molecular and Cellular Biology."
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