Cardiac Autonomic Neuropathy (CAN). Commonly assessed by heart rate
variability (HRV)
(72)
is associated with hyperglycemia
(73)
and with recurrent
hypoglycemia
(74)
. CAN was associated prospectively with increased arterial
stiffness among individuals with T1D
(75)
, and low HRV predicted a 2-3 fold
increase in mortality among adults with diabetes, independent of other risk factors
(76)
.
Among 130 newly diagnosed patients with T1D in Germany, the prevalence of
CAN was 16.9%
(77)
and ranged from 6-34% with longer duration of T1D
(77, 78)
.
Evidence of CAN was also observed in two additional studies of youth with T1D
(79, 80)
and HRV was correlated with long term glycemia (over 4 years)
(79)
.
Pilot data on diabetic neuropathy have been collected on a small number of
individuals from the 2002-2005 SEARCH cohort during SEARCH 2, Year 5 as
