Eligibility and Anticipated Sample Size Individuals registered in the SEARCH cohort with a diagnosis of non-gestational diabetes
in incident years 2002-2005, 2006 and 2008 and who completed a SEARCH baseline in-
person visit in one of the SEARCH clinical centers will be eligible for the new SEARCH
Cohort Study once they have had diabetes for at least 5 years. We will determine an
algorithm that optimizes duration of disease over the data collection years of the Cohort
Study, considering both diagnosis year and the timing of the most recent SEARCH visit
during the SEARCH 2 protocol. We anticipate that the average duration of diabetes will
be 8-9 years (range 6-14 yrs diabetes duration), and the average age of participants at the
time of the SEARCH Cohort Visit will be about 20 years (range 8-32 yrs old). Our goal
is to have 80% of eligible members of the cohort attend the proposed SEARCH Cohort
Study visit, for a total of 3145 participants with a Cohort Study visit.
Of the 20% not attending the research clinic visit, an additional 10% will be participate
by completion of surveys by telephone or internet, for a total of 90% inclusion or 3550 individuals. Based on proportions of youth in sub-groups of diabetes type and
race/ethnicity, the anticipated numbers and characteristics of anticipated participants in
the SEARCH Cohort Study data collection are displayed in Table 5-1.
