1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

N.M. McKeown, J.B. Blumberg and C-Y.O. Chen. USDA at 

Tufts Univ.

3:30 

125.3 

Tissue distribution of nobiletin and its 

metabolites in mice after oral administration of nobiletin. 

M. 

Wang, J. Zheng, Z. Zhong, M. Song and X. Wu. Univ. of 

Massachusetts Amherst.

3:45 

125.4 

Relationship between in vitro absorption of 

chondroitin sulfate (cs) and its molecular weight. 

L. Surapaneni, 

V. Haley-Zitlin, A. Bodine, X. Jiang and J. Brooks. Clemson 

Univ. and Pharmavite LLC, Northridge, CA.

4:00 

125.5 

Fatty acid bioavailability study of single oral 

doses of milled chia seed snack clusters or chia seed oil in 

healthy subjects. 

D.C. Nieman, N.D. Gillitt, A.M. Knab, L. 

Cialdella-Kam and F. Jin. Appalachian State Univ. and Dole 

Nutr. Res. Lab., Kannapolis.

SUNDAY NUTRITION

36

4:15 

125.6 

Absorption, distribution, metabolism and 

elimination of a stable isotope-labelled anthocyanin in humans. 

C.D. Kay, N.P. Botting, A. Cassidy, C. Czank, R. de Ferrars, 

P.A. Kroon, D.J. Morrison, T. Preston and Q. Zang. Univ. of 

East Anglia, Univ. of St Andrews, Inst. of Food Res., Norwich 

and Univ. of Glasgow, U.K.

4:30 

125.7 

The metabolic fate of anthocyanins in humans. 

R.M. de Ferrars, A. Cassidy, P. Curtis, K. Saki Raheem, Q. 

Zhang and C.D. Kay. Univ. of East Anglia and St Andrews 

Univ., U.K.

4:45 

125.8 

High amylose and stearic acid-modified 

resistant starch: human post-prandial gut fermentation and 

blood glucose response. 

E. Haugabrooks, Y. Ai, J-l. Jane and 

S. Hendrich. Iowa State Univ.

126.  OBESITY: CARBOHYDRATE INTAKE AND 

WEIGHT MANAGEMENT

Minisymposium

(Sponsored by: Obesity RIS)

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3:00 

126.1 

Sugar-sweetened beverage consumption is 

associated with relative distribution of abdominal adipose tissue 

in the Framingham Heart Study. 

J. Ma, M. Sloan, C.S. Fox, U. 

Hoffmann, P.F. Jacques and N.M. McKeown. USDA at Tufts 

Univ., Univ. of Massachusetts Med. Sch., NHLBI, Framington 

Heart Study, Harvard Med. Sch. and Massachusetts Gen. 

Hosp.

3:15 

126.2 

Liquid and solid sources of added sugar and 

their associations with body weight and metabolic syndrome 

components in children. 

J. Wang, K. Light, L. Johnson-

Down, D. St-Arnaud-McKenzie, J. O’Loughlin, G. Paradis 

and K. Gray-Donald. McGill Univ., Ste. Anne de Bellevue and 

Montreal and Univ. of Montreal.

3:30 

126.3 

Drinking water to dilute urine osmolality is 

associated with greater weight loss in pre-adolescents eating 

lower glycemic foods. 

J.J.D. Stookey, R. Del Toro, J. Hamer, 

A. Medina, J. King, A. Higa and V. Ng. Children’s Hosp. & Res. 

Ctr. Oakland.

3:45 

126.4 

Effect of two oat-based breakfast cereals on 

appetite, satiety, and food intake. 

C.J. Rebello, W. Johnson, C. 

Martin, N. Bordenave, B.J.W. van Klinken, M. O’Shea, Y. Chu 

and F. Greenway. Pennington Biomed. Res. Ctr., Baton Rouge 

and PepsiCo Inc. Barrington, IL.

4:00 

126.5 

Predicting satiety responses of cereals in vitro: 

oatmeal shows gastric gelling behavior. 

B.J-W. van Klinken, 

Y. Chu, N. Bordenave, C. Vink, S. de Jong, R. Ruijschop, T. 

Lambers and M. O’Shea. PepsiCo, Barrington, IL and Nizo 

Foods, Ede, Netherlands.

4:15 

126.6 

Association of whole grain intake and 

longitudinal changes in abdominal adiposity in the Framingham 

Heart Study. 

H. Wang, P. Quatromoni, C.S. Fox, P.F. Jacques 

and N.M. McKeown. USDA at Tufts Univ., Boston Univ., 

NHLBI’s Framingham Heart Study, Brigham and Women’s 

Hosp. and Friedman Sch. of Nutr. Sci. and Policy, Tufts Univ.

4:30 

126.7 

Determination of the glycemic index of a weight 

loss meal plan program using energy controlled, pre-packaged 

products. 

M. Nichols, A.M. Jenkins, A.N. Fabricatore, V. 

Vuksan, T.M.S. Wolever and B.P. Daggy. Nutrisystem Inc., 

Fort Washington, PA and Glycemic Index Labs. Inc., Toronto.

4:45 

126.8 

Sodium alginate addition to chocolate milk 

reduces appetite and glycemic responses in healthy young 

men. 

D. El Khoury , H.D. Goff, S. Berengut, N. Yavorska, 

R. Kubant and G.H. Anderson. Univ. of Toronto and Univ. of 

Guelph.

127.  POLYUNSATURATED FATTY ACIDS AND 

HEALTH

Minisymposium

(Sponsored by: Energy and Macronutrient Metabolism RIS)

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3:00 

127.1 

Perinatal and post-weaning diets high in 

omega-3 fatty acids upregulate genes involved in neurotrophin 

signaling. 

K.A. Balogun and S.K. Cheema. Mem. Univ. of 

Newfoundland.

3:15 

127.2 

Maternal n-3 fatty acid supplementation before 

and during pregnancy provides neuroprotection after neonatal 

hypoxic-ischemic brain injury. 

C. Fan, K. Mayurasakorn, V.S. 

Ten, K. Qi and R.J. Deckelbaum. Columbia Univ. Med. Ctr., 

Beijing Children’s Hosp., Capital Med. Univ.

3:30 

127.3 

Race, pregravid BMI and gestational weight 

gain determine placental fatty acid transfer. 

A.R. Smither, 

H.A. Durham, S. Buzhardt, F.A. Moore, W.T. Cefalu and C.J. 

Lammi-Keefe. LSU, Pennington Biomed. Res. Ctr., Woman’s 

Hosp. and LSU AgCtr., Baton Rouge.

3:45 

127.4 

The Sydney Diet Heart Study: a randomised 

controlled trial of linoleic acid for secondary prevention of 

coronary heart disease and death. 

C.E. Ramsden, D. Zamora, 

K. Faurot, S. Majchrzak and J. Hibbeln. NIAAA, NIH and 

Univ. of North Carolina at Chapel Hill.

4:00 

127.5 

Differential effect of docosahexaenoic acid 

versus myrisitc acid on inflammatory cytokines. 

K.L. Honda, 

N.R. Matthan, S. Lamon-Fava, D. Wu and A.H. Lichtenstein. 

USDA at Tufts Univ.

4:15 

127.6 

EPA promotes fatty acid storage and 

thermogenic capacity in primary differentiated mouse 

subcutaneous adipocytes. 

M. Zhao and X. Chen. Univ. of 

Minnesota-Twin Cities, St. Paul.

4:30 

127.7 

Effects of modifying both the linoleic and 

linolenic acid content of a 45% kcal DIO diet on body weight 

and metabolic parameters in C57BL6J mice. 

R.E. Ward, A. 

Zhou, M. Lefevre and K. Hintze. Utah State Univ.

4:45 

127.8 

Establishing and maintaining the complex 

adhesions of the testes: a role for the omega-3 DHA. 

T.L. 

Abbott, R.A. Hess, M. Sivaguru and M.T. Nakamura. Univ. of 

Illinois, Urbana.

NUTRITION SUNDAY

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Pathology

130.  MOLECULAR AND CELLULAR BASIS OF 

DISEASE: STEM CELLS, NEOPLASIA, 

DEVELOPMENT, WOUND HEALING (PART 1)

Symposium

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Stem Cells

Neoplasia

8:30 

P13 kinase signaling and cancer. 

P. Shepherd. Univ. of 

Auckland.

9:15 

Neural stem cell control by Hedgehog and Notch 

signaling. 

A. Gulino. Sapienza Univ. of Rome. 

10:10 

Wnt signaling in GI development and tumorigenesis. 

R. 

Shivdasani. Dana Farber Cancer Inst.

10:45  Beta-catenin in liver development/liver tumors. 

S. P.S. 

Monga. Univ. of Pittsburgh. 

131.  MUCOSAL MICROBIAL INTERACTIONS

Minisymposium

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Epithelial Pathobiology

8:30 

131.1 

Gut microbiota biofilm disruptions by Giardia: 

pathology in human enterocytes and germ-free mice. 

J. Beatty, 

S. Akierman, K. Rioux, P. Beck, W. McKnight, T. Feener, J. 

Wallace and A. Buret. Univ. of Calgary and McMaster Univ., 

Canada.

8:45 

131.2 

Transepithelial movement of intestinal 

pathogens is limited by 

gd IEL occludin-dependent migration. 

K.L. Edelblum, G. Singh, R. McLeod and J.R. Turner. Univ. of 

Chicago.

9:00 

131.3 

Microbiota-dependent Th17 and Foxp3

+

 

regulatory T cell differentiation in the intestinal lamina propria. 

D. Geem, O. Medina-Contreras, R. Newberry and T.L. 

Denning. Emory Univ. and Washington Univ. Sch. of Med.

9:15 

131.4 

Symbiotic lactobacilli stimulate metazoan gut 

proliferation via induction of reactive oxygen species by Nox1. 

R. Jones, A. Alam, L. Luo, C.S. Ardita and A.S. Neish. Emory 

Univ. Sch. of Med.

9:30 

131.5 

Regional Wnt signatures in the colon and the 

influence of commensal bacteria. 

P.A. Neumann, S. Koch, R. 

Hilgarth, E. Perez-Chanona, C. Jobin, C.A. Parkos and A. 

Nusrat. Emory Univ. Sch. of Med., German Cancer Res. Ctr. 

Heidelberg and Univ. of North Carolina at Chapel Hill.

9:45 

131.6 

Salmonella typhimurium directs the localization 

of the desmosomal protein, PERP, to induce inflammation. 

K. 

Hallstrom, J.E. Casanova and B.A. McCormick. Univ. of 

Massachusetts Med. Sch. and Univ. of Virginia Hlth. Syst.

10:00 

131.7 

Fundamental role for HIF-1

a in expression 

of enteric human 

b defensin-1. C.J. Kelly, L.E. Glover, E.L. 

Campbell, S.F. Ehrentraut, D.J. Kominsky, B.E. Bowers, A.J. 

Bayless, B.J. Saeedi and S.P. Colgan. Univ. of Colorado Sch. 

of Med.

128.  CAREER DEVELOPMENT WORKSHOP AND 

BREAKFAST: NON-TRADITIONAL CAREER 

OPPORTUNITIES IN PATHOLOGY

Workshop

(Sponsored by: ASIP Committee for Career 

Development, Women & Minorities, the Intersociety 

Council for Pathology Information and FASEB MARC 

(Maximizing Access to Research Careers) Office)

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Career Development

Graduate students and postdoctoral fellows are often 

exposed to only a limited range of career options. All are familiar 

with academic careers that range from tenure-track faculty 

slots to temporary research positions. Many are also aware of 

increasingly scarce teaching positions in liberal arts colleges, and 

some may aspire to bench research positions in pharmaceutical 

and biotech companies, which are highly competitive. Few, 

however, realize that PhD scientists can play major roles in non-

bench positions in industry, both as independent consultants or 

as employees of contract research organizations, pharmaceutical 

companies, biotech companies, or other organizations. The 

speakers will outline their important, rewarding, and well-paid 

roles in industry in running clinical trials, educating medical and 

scientific professionals, and helping to guide new therapeutics 

through the drug approval process in the U.S. and other countries.

7:00 Introduction.

7:10 

Implementing clinical trials as a clinical research 

associate (CRA). 

M. Gentile. Independent Consultant.

7:30 

Teaching therapeutic science as a medical science 

liaison (MSL). 

U. Atif. Shire.

7:50 

Toxicologic pathologists in biopharmaceutical discovery 

and development. 

J. Fikes. AstraZeneca.

8:10 

Panel discussion.

129.  EXTRACELLULAR VESICLES, MIRNA AND 

VASCULAR CELL COMMUNICATION

Symposium

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Vascular Biology

8:30 

Tumor extracellular vesicles as saboteurs, biomarkers 

and therapeutic agents. 

X. Breakefield. 

Massachusetts Gen. Hosp.

9:15 

Exosomes mediate the therapeutic effects of endothelial 

progenitor cells for ischemic tissue repair. 

D. Lorsodo. 

Northwestern Univ., Chicago.

10:00  Immunoregulatory exosomes: novel therapeutics for 

treating autoimmune and nflammatory diseases. 

P. 

Robbins. Univ. of Pittsburgh and Scripps Res. Inst.

10:45  Tissue factor, microparticles and thrombosis. 

N. 

Mackman. Univ. of North Carolina at Chapel Hill.

SUNDAY PATHOLOGY

38

10:15 

131.8 

Cleavage of interleukin-8 and attenuation of 

neutrophil chemotaxis by a Giardia cathepsin B. 

J. Cotton, A. 

Bhargava, J. Ferraz, M. Hollenberg, P. Beck and A. Buret. 

Univ. of Calgary, Canada.

10:30 

131.9 

The role of shiga toxin in promoting 

transepithelial migration of neutrophils. 

E.J. Boll, R. Szabady, 

D. Jandhyala, C. Thorpe and B. McCormick. Univ. of 

Massachusetts Med. Sch. and Tufts Med. Ctr.

10:45 

131.10  Human airway secretions inhibit Pseudomonas 

aeruginosa activity: effects on survival, growth, and flagellar 

motility. 

A.K. Weitz, J.L. Willborg, S.M. Hinz and J.L. Bankers-

Fulbright. Augsburg Col., MN.

11:00 

131.11  Commensal  Lactobacillus modulate ROS-

dependent cytoprotective gene expression in intestinal 

epithelia. 

C.S. Ardita, R.M. Jones, J.W. Mercante, L. Luo, C. 

Gates, K.H. Moberg and A.S. Neish. Emory Univ.

11:15 

131.12  Colonic MUC2 mucin regulates the expression 

and antimicrobial activity of 

b-defensin 2. E.R. Cobo, V. 

Kissoon-Singh, E. Trusevych, F. Moreau and K. Chadee. 

Univ. of Calgary, Canada.

132.  CELL MATRIX ADHESION AND WOUND REPAIR

Minisymposium

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8:30 

132.1 

The effect of adiponectin on intestinal 

fibroblasts. 

C.M. Williams, R. Fayad, M.K. Anderson and 

T.A. Reaves. Med. Univ. of South Carolina and Univ. of South 

Carolina.

8:45 

132.2 

CCN1/Cyr61 regulates sonic hedgehog 

signaling through activation of Notch-1 in pancreatic 

carcinogenesis: a novel targeting pathway for pancreatic 

cancer therapy. 

I. Haque, A. De, M. Majumder, S. Mehta, D. 

McGregor, S.K. Banerjee, P.V. Veldhuizen and S. Banerjee. 

Univ. of Kansas Med. Ctr. and Kansas City VA Med. Ctr.

9:00 

132.3 

Epithelial wound repair: insights into the 

multifaceted roles of annexin A1. 

G. Leoni, P-A. Neumann, 

A. Alam, R.S. Hilgarth, D.J. Lambeth, D. Kusters, C. 

Reutelingsperger, M. Perretti, C.A. Parkos, A.S. Neish 

and A. Nusrat. Emory Univ., CARIM Sch. for Cardiovas. Dis., 

Maastricht and William Harvey Res. Inst., London, U.K.

9:15 

132.4 

An extracellular matrix-based mechanism of 

rapid neutrophil extracellular trap formation in response to 

C. albicans. 

A.S. Byrd, X.M. O’Brien, C.M. Johnson, L.M. 

Lavigne and J.S. Reichner. Rhode Island Hosp. and Warren 

Alpert Med. Sch. and Grad. Prog. in Pathobiol.

9:30 

132.5 

aSNAP controls b1-integrin trafficking and 

FAK/Src dependent cell-matrix adhesions in human epithelial 

cells. 

N.G. Naydenov, A. Feygin and A.I. Ivanov. Virginia 

Commonwealth Univ.

9:45 

132.6 

Resolvin D1 receptor activation counter-

regulates H1 histamine receptors in human and rat conjunctival 

goblet cells. 

R.R. Hodges, D. Li, R.B. Carozza, J. Jiao, M.A. 

Shatos, N. Chiang, C.N. Serhan and D.A. Dartt. Schepens 

Eye Res. Inst./Massachusetts Eye and Ear, Harvard Insts. of 

Med. and Harvard Med. Sch.

10:00 

132.7 

g-Cytoplasmic actin modulates epithelial to 

myofibroblast transition in lung epithelial cells. 

S. Baranwal, P. 

Gupta and A.I. Ivanov. Virginia Commonwealth Univ. Sch. of 

Med.

10:15 

132.8 

The N-formyl peptide receptor 1 is required 

for enteric commensal mediated mucosal homeostasis and 

restitution. 

A. Alam, G. Leoni, C. Wentworth, J. Kwal, R. 

Jones, C. Ardita, P. Swanson II, A. Nusrat and A. Neish. 

Emory Univ. Sch. of Med.

10:30 

132.9 

Novel role of suppressor of cytokine signaling 

3 in regulating LPS-induced matrix metalloproteinase 13 gene 

expression in osteoblasts. 

A. Gao, A. Kantarci, H. Gao and T. 

Van Dyke. The Forsyth Inst. and Brigham and Women’s Hosp.

10:45 

132.10  MUC2 exocytosis in intestinal goblet cells. S. 

Cornick, F. Moreau and K. Chadee. Univ. of Calgary, Canada.

11:00 

132.11  Aortic carboxypeptidase-like protein enhances 

lung myofibroblast differentiation. 

K.E. Tumelty, B.D. Smith 

and M.D. Layne. Boston Univ. Sch. of Med.

133.  13TH ANNUAL CAREER DEVELOPMENT 

PROGRAM AND LUNCH: DANCING WITH 

JOURNALS: A GUIDE TO MANUSCRIPT 

SUBMISSION AND REVIEW

Special Session

(Sponsored by: ASIP Committee for Career 

Development, Women & Minorities, American Association 

of Anatomists and the FASEB MARC (Maximizing Access 

to Research Careers) Program)

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Career Development

This session is cosponsored by the ASIP Committee for 

Career Development, Women & Minorities and the American 

Association of Anatomists. All participants in Experimental 

Biology 2013 are invited to attend; however, special registration 

is required so we can reserve sufficient seats for this lunch event. 

“Dancing with Journals: A Guide to Manuscript Submission and 

Review” offers a unique opportunity to gain an insider’s view of 

how to get your scientific research published in a peer-reviewed 

journal. Editors-in-chief of successful scientific journals will 

share their insights into processes of manuscript preparation 

(including scientific integrity) and review and editorial decision-

making. Following the editors’ presentations, participants will 

have an opportunity to ask questions. There will also be time to 

become acquainted with other trainees and junior faculty at other 

institutions. Pre-registration is required for this session. Lunch is 

provided. You can register for this optional event when you register 

for the EB 2013 meeting or can obtain a ticket at the meeting (if 

seats are still available) at the EB registration desk.