1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

Tabin. Harvard Med. Sch.

23

S

U

N

76.  EVOLUTION OF HOST-PATHOGEN 

INTERACTIONS: UNDERSTANDING HOW 

MICROBIAL PATHOGENS HIJACK HOST CELLS

Symposium

s

un

. 2:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 102aB

C

haired

: J. G

uttman

Cell Biology

2:30 

76.1 

Systems biology analysis of HIV-host 

interactions. 

J.A.T. Young. Salk Inst.

3:00 

76.2 

Mobilization of the actin cytoskeleton by 

microbial pathogens. 

M. Welch, S. Reed and R. Lamason. 

Univ. of California, Berkeley.

3:30 

76.3 

Host pathogen interactions: new lessons from 

Listeria monocytogenes. 

P. Cossart. INSERM U604, Inst. 

Pasteur, Paris.

77.  CURRENT RESEARCH ON CURRICULAR 

CHANGES AND THEIR IMPACT ON STUDENT 

KNOWLEDGE

Symposium

(Cosponsored by: Anatomical Sciences Education)

s

un

. 2:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 104aB

C

haired

: r. D

raKe

Education & Teaching

2:30 

77.1 

Current curricular trends in the anatomical 

sciences: the 2012 survey. 

J.M. McBride and R.L. Drake. 

Cleveland Clin. Lerner Col. of Med. of CWRU.

3:00 

77.2 

Duration of anatomy courses and performance 

on the USMLE Step 1 and Step 2 examinations: is there a 

relationship? 

W. Pawlina, M.M. Cuddy, D.B. Swanson and 

R.L. Drake. Col. of Med., Mayo Clin., Natl. Board of Med. 

Examiners, Philadelphia and Cleveland Clin. Lerner Col. of 

Med. of CWRU.

3:30 

77.3 

Retention of anatomical knowledge: impact of 

current curricular approaches. 

R.L. Drake, J.M. McBride and 

W. Pawlina. Cleveland Clin. Lerner Col. of Med. of CWRU and 

Mayo Med. Sch.

78.  THE USE OF PLURIPOTENT STEM CELLS IN 

DISEASE MODELING

Symposium

(Cosponsored by: AAA’s Advisory Committee for Young 

Anatomists)

s

un

. 2:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 104C

C

haired

: l. o

oi

2:30 

 

Chair’s introduction.

2:35 

78.1 

Stem cells, pluripotency and nuclear 

reprogramming. 

R. Jaenisch. MIT.

3:25 

78.2 

Disruption and therapeutic rescue of a human 

pluripotent stem cell-derived model of Niemann Pick type C1. 

M.P. Ordonez and L.S.B. Goldstein. UCSD.

3:40 

78.3 

Induced pluripotent stem cells as tools for 

disease modeling and drug discovery in Alzheimer’s disease. 

L. Ooi. Univ. of Wollongong, Australia.

3:55 Discussion.

79.  FORM, FUNCTION, AND EVOLUTION

Platform

s

un

. 2:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 105

C

haired

: C. h

olliDay

2:30 

79.1 

Evolution of the respiratory system in 

Testudines: anatomy and phylogeny. 

E.R. Schachner, T.R. 

Lyson and C.G. Farmer. Univ. of Utah and Natl. Museum of 

Nat. Hist., Washington, DC.

2:45 

79.2 

Seeing terrestrial avian locomotion with X-ray 

eyes. 

R. Kambic and S. Gatesy. Brown Univ.

3:00 

79.3 

Evolution of the in-series circulation in 

tetrapods: form follows function. 

T. Owerkowicz and J.W. 

Hicks. California State Univ., San Bernardino and Univ. of 

California, Irvine.

3:15 

79.4 

3D geometric morphometric analysis 

of phenotypic plasticity in the pectoral girdle of a basal 

actinopterygian fish. 

T.Y. Du, E.M. Standen and H.C.E. 

Larsson. McGill Univ.

3:30 

79.5 

Cutting the cost of crouching: over-ground and 

tunnel locomotion in a tunnel specialist. 

A. Horner, S. Moritz 

and N. Konow. Brown Univ.

3:45 

79.6 

Form, function, and evolution of archosaur 

mandibular symphyses. 

C.M. Holliday. Univ. of Missouri-

Columbia.

80.  AAA YOUNG INVESTIGATOR AWARDS 

SYMPOSIUM

Special Session

s

un

. 4:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 104C

4:30 

80.1 

Stepping into a tense relationship: mechano-

molecular regulation of cell division by force. 

T. Maresca. Univ. 

of Massachusetts Amherst.

5:00 

80.2 

Dopamine and anti-dopamine systems: polar 

opposite roles in behavior. 

T.C. Jhou. Med. Univ. of South 

Carolina.

5:30 

80.3 

Enhancer-mediated regulation of 

developmental gene expression. 

J. Wysocka. Stanford Univ. 

Sch. of Med.

6:00 

80.4 

Unraveling the complexity of the skull: an evo-

devo approach. 

T. Franz-Odendaal. Mount Saint Vincent Univ., 

NS, Canada.

SUNDAY ANATOMY

24

Biochemistry and Molecular Biology

11:20  Molecular basis of histone acetyllysine recognition by the 

BRPF1 bromodomain. 

K.C. Glass, A. Poplawski, K. Hu, W. 

Lee, D. Peng, S. Carlson, X. Shi and M. Westler. Albany Col. 

of Pharm. and Hlth. Sci., Colchester, VT, Univ. of Wisconsin-

Madison and Univ. of Texas MD Anderson Cancer Ctr. 

(770.3)

11:35 

84.3 

Regulation and specificity of the Chd1 

chromatin remodeler. 

G. Bowman, A. Patel, S. Chakravarthy 

and I. Nodelman. Johns Hopkins Univ. and Argonne Natl. Lab., 

Lemont, IL.

12:00   

Discussion and closing remarks.

85.  O-MANNOSE GLYCANS AND MUSCULAR 

DYSTROPHY

Symposium

s

un

. 9:55 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 253a

C

haired

: p. s

tanley

9:55 

 

Chair’s introduction.

10:00 

85.1 

Molecular basis for dystroglycan binding 

to laminin-G domain-containing ligands. 

K.P. Campbell, T. 

Yoshida-Moriguchi, Y. Hara and K-i. Inamori. Univ. of Iowa/

HHMI.

10:25  The C-mannosyltransferase. 

H. Bakker, F.F.R. Buettner 

and A. Ashikov. Hannover Med. Sch., Germany. (824.2)

10:40 

85.2 

The mammalian O-mannosylation pathway: 

protein substrates, enzymes, and structures. 

L. Wells, S. 

Stalnaker, C. Dobson, R. Stuart and J. Praissman. Univ. of 

Georgia.

11:05   

Conformational consequences of O-GalNAc 

and O-Man protein modifications: implications for the structural 

role of O-GalNAc in the mucin-like region of alpha-dystroglycan. 

D. Live, L. Foley and A. Borgert. Univ. of Georgia and 

Gundersen Lutheran Med. Fndn., La Crosse, WI. 

(823.1)

11:20  

Does the phosphomannomutase pmm1 

functionally compensate for decreased pmm2 expression in 

a zebrafish model for PMM2-CDG? 

R.A. Steet, A. Cline, N. 

Gao, H. Flanagan-Steet and M. Lehrman. Univ. of Georgia 

and Univ. of Texas Southwestern Med. Ctr. 

(830.1)

11:35 

85.3 

The role of protein O-mannosylation during 

mouse development. 

S. Strahl, M. Lommel, T. Willer, M.R. 

Schneider, M. Dahlhoff and E. Wolf. Univ. of Heidelberg, 

HHMI/Univ. of Iowa and Ludwig Maximilian Univ. Munich.

12:00   

Discussion and closing remarks.

86.  UBIQUITIN AND UBIQUITIN-LIKE 

MODIFICATIONS

Symposium

s

un

. 9:55 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 254aB

C

haired

: h. D

arWin

9:55 

 

Chair’s introduction.

10:00 

86.1 

Twists and turns in ubiquitin conjugation 

cascades. 

B.A. Schulman. St. Jude Children’s Res. Hosp./

HHMI.

10:25 

 

Unraveling the specificity in the ubiquitin 

system.

 D. Komander. MRC Lab. of Molec. Biol. (553.26)

81.  ASBMB BOSTON TEA PARTY: 

UNDERGRADUATE BREAKFAST SESSION WITH 

HELEN M. BERMAN

Special Session

(Supported by an educational grant from the National 

Science Foundation)

s

un

. 7:00 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 255

Advance event registrants receive priority seating. 

All other undergraduates will be accommodated as space 

permits.

82.  AVANTI AWARD IN LIPIDS LECTURE

Award

(Supported by an educational grant from Avanti Polar 

Lipids, Inc.)

s

un

. 8:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 258a

8:30 

Introductory remarks. 

G. M. Carman.

8:35 

82.1 

The dynamic roles of phospholipid and 

triacylglycerol metabolism in regulation and signaling in yeast. 

S.A. Henry. Cornell Univ.

83.  RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE 

AWARD LECTURE

Award

s

un

. 9:05 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 258a

9:05 

 

Introductory remarks. 

S. J. Booker.

9:10 

83.1 

Natural products as powerful tools for drug 

discovery: insights from the phorbol esters. 

P.M. Blumberg. 

NCI, NIH.

84.  CHROMATIN REMODELING DURING 

TRANSCRIPTION

Symposium

s

un

. 9:55 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 252aB

C

haired

: G. n

arliKar

9:55 

 

Chair’s introduction.

10:00 

84.1 

Regulation of ATP-dependent chromatin 

remodeling. 

B. Cairns and C. Clapier. HHMI, Huntsman 

Cancer Inst., Univ. of Utah.

10:25  Mediator affects Pol II recruitment and nucleosome 

displacement at heat shock protein genes in Saccharomyces 

cerevisiae. 

Y. Moustafa and D.S. Gross. LSU Hlth. Sci. Ctr., 

Shreveport. 

(769.9)

10:40 

84.2 

Chromatin assembly and disassembly. 

J. Tyler. 

MD Anderson Cancer Ctr.

11:05  A histone acetylation switch regulates H2A.Z deposition 

by the SWR-C remodeling enzyme. 

S. Watanabe and C. 

Peterson. Univ. of Massachusetts Med. Sch. (770.4)

BIOCHEMISTRY SUNDAY

25

S

U

N

10:40 

86.2 

Mechanisms of protein quality control 

degradation in the nucleus. 

R. Gardner, E. Fredrickson, J. 

Rosenbaum and P. Gallagher. Univ. of Washington.

11:05   

Structure-function studies of the Golgi Dsc E3 

ligase complex required for SREBP activation in yeast. 

P.J. 

Espenshade, S.J-A. Lloyd, Z. Tong and S. Raychaudhuri. 

Johns Hopkins Univ. Sch. of Med. 

(557.2)

11:20  

RNF4-dependent hybrid SUMO-ubiquitin 

chains are signals for RAP80 and thereby mediate the 

recruitment of BRCA1 to sites of DNA damage. 

C.M. Guzzo, 

C.E. Berndsen, J. Zhu, V. Gupta, A. Datta, R.A. Greenberg, 

C. Wolberger and M.J. Matunis. Johns Hopkins Univ., James 

Madison Univ. and Univ. of Pennsylvania. 

(782.7)

11:35 

86.3 

Regulation of the proteasome by ubiquitin 

chain editing. 

D. Finley. Harvard Med. Sch.

12:00   

Discussion and closing remarks.

87.  FUNCTION AND EVOLUTION OF METABOLIC 

NETWORKS

Symposium

s

un

. 9:55 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 253C

C

haired

: r. D

e

B

erarDinis

9:55 

 

Chair’s introduction.

10:00 

87.1 

How do microbes control their metabolic 

operation. 

U. Sauer. ETH Zurich.

10:25   

Human melanoma metabolic network analysis 

with combined ,

13

C NMR/bioreactor technique: testing the 

Warburg effect. 

A. Shestov, A. Mancuso, J.W. Locasale and 

J.D. Glickson. Cornell Univ. and Univ. of Pennsylvania. (798.1)

10:40 

87.2 

Reconstruction and evolution of metabolic 

networks across a phylogenetic tree. 

D. Vitkup. Columbia Univ.

11:05   

Metabolic disorder in a mouse model on an 

American diet: proteomic analysis of cardiovascular disease. 

S.A. Whelan, M.E. Mccomb, J.L. Spencer, C.F. Heckendorf, 

M.M. Bachschmid, D.A. Siwik, W. Colucci, R.A. Cohen and 

C.E. Costello. Boston Univ. Sch. of Med. (794.17)

11:20   

Spatial reorganization of yeast moonlighting 

protein, enolase, in hypoxia to alter carbon metabolism. 

N. 

Miura, M. Shinohara, Y. Tatsukami, H. Morisaka, K. Kuroda 

and M. Ueda. Kyoto Univ. (791.2)

11:35 

87.3 

Promiscuous enzymes and serendipitous 

metabolic pathways. 

S.D. Copley and J. Kim. Univ. of Colorado 

Boulder.

12:00   

Discussion and closing remarks.

88.  JOBS IN INDUSTRY

Symposium

(Sponsored by: ASBMB Minority Affairs Committee)

s

un

. 9:55 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 253B

C

haired

: n. o. C

onCha

9:55 

 

Chair’s introduction.

10:00 

88.1 

Scientific jobs – an industrial perspective. 

N.O. 

Concha. GlaxoSmithKline.

10:30 

88.2 

Life as a minority scientist in industry and 

academia. 

G.D. Dotson. Univ. of Michigan Col. of Pharm.

11:00 

88.3 

What are the advantages/disadvantages of 

postdoctoral training in industry? 

L. Saleh. New England 

Biolabs, Ipswich, MA.

11:30   

Panel discussion.

89.  TRANSITIONING BEYOND THE BENCH

Symposium

s

un

. 9:55 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 251

C

haired

: J. F

errini

-m

unDy

9:55 

 

Chair’s introduction.

10:00 

89.1 

Careers beyond the bench – an overview. 

D. 

Zuk. NIH.

10:10   

Incorporating biotechnology in the high school 

classroom: professional development for biology teachers. 

J.L. 

Bisogno and M.J. Koroly. Univ. of Florida. (838.6)

10:20 

89.2 

Moving from the lab to the law. 

R. Plotkin. 

Robert Plotkin PC, Burlington, MA.

10:30   

The MESA program advantage in STEM 

education. 

R. Bakhiet, T. Carcia and R. Alvarez. Southwestern 

Col., CA, San Diego State Univ. Col. of Engin. and San Diego 

City Col. 

(838.14)

10:40 

89.3 

One teacher’s journey from the bench to the 

classroom. 

J. Cruzan. Moses Brown Sch., RI.

10:50  

Discussion.

90.  ASBMB BUSINESS MEETING

s

un

. 12:15 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 258a

Learn how your Society works for you and understand 

the business of ASBMB. The Business Meeting is immediately 

followed by, “How Scientists Can Save the World,” A Public Policy 

Forum, also in Room 258 A.

91.  ASBMB AWARD FOR EXEMPLARY 

CONTRIBUTIONS TO EDUCATION LECTURE

Award

(Sponsored by: ASBMB Education and Professional 

Development Committee)

s

un

. 12:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 257aB

Undergraduate Poster Competition awards will be 

presented during this lecture.

12:30   

Introductory remarks and awards presentation. 

M. Bradley and K. Cornely.

12:45 

91.1 

From the classroom to communities: connecting 

students in the sciences to real world situations. 

J.M. Ntambi. 

Univ. of Wisconsin-Madison.

SUNDAY BIOCHEMISTRY

26

92.  COMPUTATIONAL TOOLS FOR ASSIGNING 

ENZYMATIC FUNCTIONS WORKSHOP: 

EXAMPLES FROM THE GLUTATHIONE 

TRANSFERASE SUPERFAMILY

Workshop

(Supported by an educational grant from Enzyme 

Function Initiative (EFI), a Large Scale Collaborative 

Project from NIGMS (U54GM093342))

s

un

. 12:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 255

C

oChaired

: J. a. G

erlt

 

anD

 p. C. B

aBBitt

Workshop features presentations describing the application 

of high throughput computational “tools” to facilitate functional 

assignment of unknown enzymes discovered in genome 

sequencing projects. The glutathione transferase superfamily will 

be used to demonstrate the utility of sequence similarity networks 

and both homology modeling and in silico ligand docking to 

provide clues for functional assignment.

12:30 

Overview of the Enzyme Function Initiative. 

J. A. Gerlt. 

Univ of Illinois at Urbana-Champaign.

12:50  Sequence similarity networks to visualize and define 

“function space” in the glutathione transferase 

superfamily. 

P. C. Babbitt. UCSF.

1:30 

An atlas of the glutathione transferase superfamily. 

R. N. 

Armstrong. Vanderbilt Univ. Med. Ctr.

1:50 

Homology modeling and ligand docking to provide 

functional insights about “unknown” glutathione 

transferases. 

A. Sali. UCSF.

2:10 

Panel discussion.

93.  HOW SCIENTISTS CAN SAVE THE WORLD

Public Affairs Workshop

s

un

. 12:45 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 258a

C

haired

: J. m. B

erG

Join the leading names in science and public policy as 

we discuss the massive challenges facing society in the next 

100 years. Learn how science holds many of the solutions to 

problems like hunger, health, and sustainability - and how to be 

an advocate for science.