1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

Panel Discussion

K. Albertine. Univ. of Utah Sch. of Med., The Anatomical  

   Record.

J. R. Couchman. Univ. of Copenhagen, Journal of 

 

   Histochemistry & Cytochemistry.

K. A. Roth. Univ. of Alabama at Birmingham, AJP.

A. Cox. ASIP, AJP.

PATHOLOGY SUNDAY

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134.  BLOOD VESSEL CLUB™: MIRNAS IN THE 

REGULATION OF BLOOD VESSEL FUNCTION

Special Session

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Vascular Biology

2:00 

 

microRNA regulation of vascular inflammation 

and angiogenesis. 

M. W. Feinberg. Brigham and Women’s 

Hosp.

3:00 

 

The role of Mirs and TLR receptors in a mouse 

model for the pathogenesis of AAAs. 

J. Galper. Tufts Univ. Sch. 

of Med.

4:00 

134.1 

microRNA-155 plays an important role in 

endothelial cell activation. 

A. Virtue, H. Wang and X-f. Yang. 

Temple Univ.

135.  MOLECULAR AND CELLULAR BASIS OF 

DISEASE: STEM CELLS, WOUND HEALING, 

REGENERATION AND CANCER (PART 2)

Symposium

(Sponsored by: ASIP and Società Italiana di Patologia e 

Medicina Traslazionale/Italian Society of Pathology and 

Translational Medicine)

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Stem Cells

Neoplasia

2:00 

Liver regeneration and HCC. 

G. K. Michalopoulos. 

Univ. of Pittsburgh.

2:35 

Wound healing and cancer or fibroblasts and cancer. 

R. 

Kalluri. MD Anderson Cancer Ctr.

3:10 

Pathogenesis and treatment of NUT midline carcinoma. 

C. A. French. Brigham and Women’s Hosp.

3:40 

Stem cells in ependymoma: implications in classification, 

prognosis and treatment. 

R. Gilbertson. St. Jude 

Children’s Res. Hosp.

4:20 

Stem cells in lung cancer. 

C. Kim. Boston Children’s 

Hosp.

136.  CELL INJURY: CELL DEATH AND SURVIVAL

Workshop

(Sponsored by: ASIP Cell Injury Scientific Interest Group)

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Cell and Tissue Injury

2:00 

Macrophages and tissue injury: agents of defense or 

destruction. 

D. L. Laskin. Rutgers Univ.

2:45 

Mitophagy in neurodegeneration: loading the banquet 

table. 

C. T. Chu. Univ. of Pittsburgh.

3:30 

Impact of exercise training in ameliorating lipid overload-

induced mitochondrial damage. 

Z. Yan. Univ. of 

Virginia.

4:15 

Two faces of nonparenchymal cells in regulation of 

hepatocyte survival. 

C. R. Gandhi. Univ. of Cincinnati.

137.  MUCOSAL DEFENSE AND INFLAMMATION

Minisymposium

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lover

2:00 

137.1 

Neutrophil-epithelial interactions modulate the 

inflammatory microenvironment during colitis. 

E.L. Campbell, 

W.J. Bruyninckx, C. Kelly, L.E. Glover, B.E. Bowers, A.J. 

Bayless, S. Ehrentraut, C.T. Taylor, D.J. Kominsky and S.P. 

Colgan.  Univ. of Colorado Denver, Aurora, Hanover Col., IN 

and University Col. Dublin.

2:15 

137.2 

Lipoxins control neutrophil superoxide 

anion production by regulation of polyisoprenyl diphosphate 

phosphatase 1 activity. 

T. Carlo, H. Kalwa and B.D. Levy. 

Brigham and Women’s Hosp., Harvard Med. Sch.

2:30 

137.3 

Regulation of mucosal restitution during acute 

inflammation: JAML shed from transmigrating neutrophils 

inhibits intestinal epithelial wound repair through binding to 

CAR. 

D.A. Weber, R. Sumagin, I.C. McCall, G. Leoni, P.A. 

Neumann, R. Andargachew, J.C. Brazil, A. Nusrat and C.A. 

Parkos. Emory Univ.

2:45 

137.4 

Vibrio parahaemolyticus VopA is a potent 

inhibitor of cell growth and cell migration in the intestinal 

epithelium. 

R. Jones, L. Luo, G. Leoni and A. Nusrat. Emory 

Univ. Sch. of Med.

3:00 

137.5 

Modulation of the inflammatory response to 

entero-hemorrhagic E. coli by the secreted mucinase StcE. 

R.L. 

Szabady, E.J. Boll, R.A. Welch and B.A. McCormick. Univ. of 

Massachusetts Med. Sch. and Univ. of Wisconsin-Madison.

3:15 

137.6 

Neutrophil-derived microparticles as novel 

effectors in joint disease. 

S.E. Headland, F. Dell’Accio and M. 

Perretti. Barts and The London Med. Sch., Queen Mary Univ. 

of London.

3:30 

137.7 

Fut3-driven expression of sialyl Lewis A on 

intestinal epithelium regulates PMN clearance. 

J. Brazil, R. 

Liu, R.D. Cummings, C.A. Parkos and N.A. Louis. Emory 

Univ.

3:45 

137.8 

Mast cell deficiency induces inflammation and 

exacerbates inflammatory bowel symptoms in IL10

-/-

 mice. 

H. 

Zhang, Y. Xue, H. Wang, Y. Huang, R.J. McCormick, W.J. 

Means, M. Du and M. Zhu. Univ. of Wyoming and Washington 

State Univ. Sch. of Food Sci.

4:00 

137.9 

Neutrophil interactions with apical epithelial 

ICAM-1 contribute to resolution of inflammation by promoting 

intestinal epithelial wound repair. 

R. Sumagin, P. Nava, A. 

Nusrat and C.A. Parkos. Emory Univ.

4:15 

137.10  Resolvin E1 enhances phagocytosis-induced 

neutrophil apoptosis. 

D. El Kebir, P. Gjorstrup and J.G. Filep. 

Univ. of Montreal and Resolvyx Pharmaceuts., Cambridge, MA.

4:30 

137.11  IFN-

g-mediated induction of an apical IL-10 

receptor on polarized intestinal epithelia. 

D.J. Kominsky, E.L. 

Campbell, C.J. Kelly, L.E. Glover, B.E. Bowers, A.J. Bayless, 

E. Dobrinskikh, S.F. Ehrentraut and S.P. Colgan. Univ. of 

Colorado Anschutz Med. Campus.

SUNDAY PATHOLOGY

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4:45 

137.12  Over-expression of RAGE by proximal lung 

epithelial cells causes an inflammatory response in adult mice. 

B.G. Bennion, B.G. Bodine, E. Leatham, A.J. Wright, Z.R. 

Jergensen, C.J. Erickson, C.M. Jones, J.P. Johnson, S.M. 

Knapp and P.R. Reynolds. Brigham Young Univ.

138.  MECHANISMS REGULATING LEUKOCYTE 

RECRUITMENT

Minisymposium

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2:00 

138.1 

Neutrophil slow rolling and intravascular 

crawling is dependent on the guanine-exchange factor P-Rex1. 

J.M. Herter, J. Rossiant, H. Block, A. Stadtmann, H. Welch 

and A. Zarbock. Univ. of Muenster, Max Planck Inst. for Molec. 

Biomed., Muenster and Babraham Inst., Cambridge, U.K.

2:15 

138.2 

Avidity regulation of the leukocyte integrin 

LFA-1. 

C.T. Lefort and K. Ley. La Jolla Inst. for Allergy and 

Immunol.

2:30 

138.3 

Integrin crosstalk regulation of human 

neutrophils adhered to fibronectin and beta-glucan. 

C.M. 

Johnson, A. Byrd and J. Reichner. Warren Alpert Med. Sch. 

of Brown Univ./ Rhode Island Hosp.

2:45 

138.4 

HS1 regulates chemokine-induced Rap-1 

activation via PKA in neutrophils to facilitate extravasation. 

M. Schnoor, J. Latasiewicz, D. Jing and D. Vestweber. 

CINVESTAV, Mexico City and Max Planck Inst. for Molec. 

Biomed., Muenster.

3:00 

138.5 

Neutrophil microparticles are heterogenous 

in content and function. 

M. Perretti, J. Dalli, L.V. Norling, T. 

Montero-Melendez and C. Hinds. Barts and The London Sch. 

of Med. and Dent.

3:15 

138.6 

a(1,3)-Fucosylated glycans on myeloid cells 

regulate IL-17-dependent granulopoiesis. 

L.C. Mackey, J.M. 

Rose, J.R. Weiss and J.W. Homeister. Univ. of North Carolina 

at Chapel Hill.

3:30 

138.7 

NLRP3 inflammasome is terminated by PGE

2

-

cAMP-PKA signaling. 

L.M. Mortimer, F. Moreau and K. 

Chadee. Univ. of Calgary, Canada.

3:45 

138.8 

Cytosolic K

+

 and extracellular Na

+

 as regulators 

of NLRP3 inflammasome activation and the IL-1

b secretion 

response of macrophages to crystalline stimuli. 

M. Katsnelson 

and G. Dubyak. Case Western Reserve Univ.

4:00 

138.9 

Resolvin D1 and resolvin D5 lower antibiotic 

doses in infection. 

N. Chiang, G. Fredman, S. Oh and C.N. 

Serhan. Brigham and Women’s Hosp., Harvard Med. Sch.

4:15 

138.10  Oral administration of anti-sPLA2-IB antibodies 

reduces sepsis mortality in murine endotoxemia. 

J. Sand, D.E. 

Butz, F. Tsao and M.E. Cook. Univ. of Wisconsin-Madison.

4:30 

138.11  CD47 reduces activation-induced CD4

+

 T cell 

death in MOG peptide-dependent experimental autoimmune 

encephalomyelitis. 

V. Azcutia, R. Bassil, S.J. Khoury, W. 

Elyaman and F.W. Luscinskas. Brigham and Women’s Hosp. 

and Harvard Med. Sch.

4:45 

138.12  Investigating novel roles for exogenous and 

endogenous galectin-3 in controlling vascular inflammation. 

B. Gittens, M. Perretti and D. Cooper. Barts and the London 

Med. Sch., Queen Mary Univ. of London.

139.  ASIP ROUS-WHIPPLE AWARD LECTURE

Lecture

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Inflammation

5:00 Introduction.

5:05  How endothelial cells regulate transmigration of 

leukocytes in the inflammatory response. 

W. A. Muller. 

Northwestern Univ. Feinberg Sch. of Med.

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POSTER PRESENTERS:  

UPLOAD YOUR POSTER

Where: E-Poster Counter, Sun. – Tue. Hall A; 

Wed. Hall C

Deadline: Tue., April 23, 5:00 

pm

 

Wed., April 24, 3:00 

pm

Uploaded posters will be available online to 

all registered attendees following the meeting 

at www. experimentalbiology.org

PATHOLOGY SUNDAY

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Pharmacology and Experimental Therapeutics

142.  NOVEL FUNCTIONS FOR CYCLIC NUCLEOTIDE 

PHOSPHODIESTERASES AND THEIR 

IMPLICATIONS FOR PHARMACOLOGICAL 

INTERVENTION

Symposium

(Sponsored by: The British Pharmacological Society 

and the ASPET Divisions for Molecular Pharmacology; 

Cardiovascular Pharmacology; Integrative Systems, 

Translational and Clinical Pharmacology; and 

Neuropharmacology)

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9:30 

Domain structure and interactions in cyclic nucleotide 

phosphodiesterases: an atomic view of PDE 

regulation. 

J. Pandit. Pfizer Global R&D, Groton Labs.

10:00  Novel insights into the mechanism of action of beta-

adrenergic antagonists: modulation of PDE4-beta-

adrenergic receptor complexes. 

W. Richter. UCSF.

10:30 

Phosphodiesterases and cyclic nucleotide 

compartments in the regulation of cardiac function. 

R. 

Fischmeister. Univ. of Paris Sud (Paris XI).

11:00 

PDE inhibitors and the treatment of airway inflammation. 

C. Page. King’s Col. London.

11:30 

Posttranslation regulation of PDE10 and the implication 

in their physiological role in the CNS and in drug 

discovery. 

N. Brandon. AstraZeneca, Cambridge.

143.  CORRELATING STRUCTURE AND FUNCTION 

OF DRUG METABOLIZING ENZYMES: AN 

ONGOING CHALLENGE

Symposium

(Sponsored by: The Divisions for Drug Metabolism and 

Toxicology)

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ohnson

9:30 

Cytochrome P450 structure: common themes and 

variations on the theme. 

E. F. Johnson. The Scripps 

Res. Inst.

10:00  Investigations of human cytochrome P450 enzymes 

with solution NMR. 

E. E. Scott. Univ. of Kansas.

10:30  Predicting ligand interactions with metabolizing 

enzymes: an in silico structure-based approach. 

M. 

Miteva. Univ. Paris Diderot.

11:00  Novel pharmacoenhancer cobicistat: discovery and 

development of a CYP3A inhibitor. 

L. Xu. Gilead Sci. 

Inc.

11:30 

Physical interactions among NADPH-cytochrome P450 

reductase, CYP1A2, and CYP2B4 in the endoplasmic 

reticulum. 

J.P. Connick, J.R. Reed and W.L. Backes. 

LSU Hlth. Sci. Ctr., New Orleans. 

(892.4)

11:40 Discussion.

140.  WORKSHOP: ART OF ITEM WRITING (NBME 

STYLE) AND BASICS OF ASSESSMENT

Workshop

(Sponsored by: The Division for Pharmacology Education 

and The National Board of Medical Examiners)

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Education

9:00 

Introduction to the workshop. Importance of correct item 

writing and current trends in recognizing educational 

research. 

S. K. Rajasekaran. Oakland Univ. William 

Beaumont Sch. of Med.

9:30 

Developing high-quality multiple-choice test items for 

basic sciences. 

A. P. Butler. Natl. Board of Med. 

Examiners.

10:30 

Setting pass/fail standards: discussing item analysis. 

S. 

Haist. Natl. Board of Med. Examiners.

11:30 

Hot topics in medical education research. 

L. M. Crespo. 

Univ. of South Carolina Sch. of Med.

141.  ORTHOSTATIC INTOLERANCE: INSIGHTS 

INTO PHARMACOLOGIC, PHYSIOLOGIC AND 

GENDER ISSUES

Symposium

(Sponsored by: Tthe Divisions for Cardiovascular 

Pharmacology and Integrative Systems, Translational and 

Clinical Pharmacology)

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9:30  Vasovagal syncope: putative triggers and 

pharmacological and physiological approaches to 

management. 

R. Hainsworth. Univ. of Leeds.

10:00 

Neural and non-neural control of orthostatic intolerance: 

implications for sex differences. 

Q. Fu. Texas Hlth. 

Presbyterian Hosp., Dallas.

10:30 

Identifying sympathetic nervous system abnormalities in 

orthostatic intolerance. 

E. Lambert. Baker IDI Heart 

and Diabetes Inst., Melbourne.

11:00  Ehlers Danlos syndrome, joint hypermobility and 

orthostatic intolerance. 

P. Rowe. Johns Hopkins 

Children’s Ctr.

11:30  Hypo-osmolality pressor stimulus is linked to transient 

receptor potential vanilloid 4 in the portal region. 

T. 

Mai, J. McHugh, A. Diedrich, E.M. Garland and D. 

Robertson. Vanderbilt Univ. and Johns Hopkins Univ. 

(884.7)

11:45  Loss of muscle sympathetic nerve activity and blood 

pressure phase synchronization in postural vasovagal 

syncope. 

C.E. Schwartz, E. Lambert, M.S. Medow 

and J.M. Stewart. New York Med. Col. and Baker 

Heart Res. Inst., Melbourne. 

(926.6)

SUNDAY PHARMACOLOGY

42

144.  COGNITIVE ENHANCERS FOR THE TREATMENT 

OF NEUROPSYCHIATRIC DISORDERS

Symposium

(Sponsored by: The Divisions for Behavioral 

Pharmacology; Integrative Systems, Translational and 

Clinical Pharmacology; and Neuropharmacology)

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9:30 

Targets for cognitive-enhancing pharmacotherapy. 

J. G. 

Wettstein. F. Hoffmann-La Roche Ltd.

9:55 

Translational approaches to cognitive enhancing drugs 

for neuropsychiatric disorders. 

T. W. Robbins. Univ. of 

Cambridge.

10:20  Novel cholinergic-based therapeutic strategies for 

Alzheimer’s disease and age-related memory decline. 

A. V. Terry. Georgia Hlth. Sci. Univ.

10:45  Therapeutic uses of cognitive enhancers in rat 

and monkey models of drug addiction. 

B. Á. Nic 

Dhonnchadha. Boston Univ.

11:10  Neuroplasticity in rodent models of fear extinction and 

use of cognitive enhancers. 

G. B. Kaplan. VA Boston 

Healthcare Syst.

11:35  Summary and discussion. 

K. M. Kantak, R. D. 

Spealman. Boston Univ., Harvard Med. Sch.

145.  EMERGING TECHNOLOGIES FOR DELIVERING 

NEUROTHERAPEUTICS ACROSS THE BLOOD-

BRAIN BARRIER

Symposium

(Sponsored by: The Divisions for Integrative Systems, 

Translational and Clinical Pharmacology; Cardiovascular 

Pharmacology; Drug Discovery and Development; and 

Neuropharmacology)

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eterson

9:30 

Chair’s introduction.

9:35 

Anatomy and physiology of the blood brain barrier (BBB) 

with special emphasis on transport of biologicals 

across the BBB and insights into the development of 

in vitro BBB model. 

E. Shusta. Univ. of Wisconsin-

Madison.

10:10  Principles for targeting tight junction proteins and 

functions.