S. Mifflin. Univ. of North Texas Hlth.
Sci. Ctr.
11:30 Evidence that 5-HT neurotransmission within the
nucleus tractus solitarii differentially modulates
glutamate release via 5-HT
3
and 5-HT
1A
receptors.
P.S. Hosford, A.G. Ramage and S. Mifflin. University
Col. London and Univ. of North Texas Hlth. Sci. Ctr.
(932.6)
11:45 Responses of neurons in the caudal medullary lateral
tegmental field to visceral inputs and vestibular
stimulation in vertical planes.
B.J. Yates, J.D. Moy,
D.J. Miller, M.F. Catanzaro, B.D. Boyle, S.W. Ogburn,
L.A. Cotter and A.A. McCall. Univ. of Pittsburgh.
(932.4)
12:00 Optogenetic stimulation of the locus coeruleus
noradrenergic neurons increase inhibitory
neurotransmission to cardiac vagal neurons in the
nucleus ambiguus.
X. Wang, R.A. Pinol and D.
Mendelowitz. George Washington Univ. (932.1)
12:15 Astrocyte damage but not microglial infiltration in the
nucleus tractus solitarii attenuates cardiovascular
reflexes.
W. Talman, S. Jones and L-H. Lin. Carver
Col. of Med., Univ. of Iowa and VA Healthcare Syst.
(932.2)
289. CELL STRESS IN LUNG DISEASE
Featured Topic
(Sponsored by: APS Respiration Section)
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am
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uluGeta
10:30 Roles of the ER stress sensors IRE1a and IRE1b in
airway inflammation and mucin production.
C. M.P.
Ribeiro. Univ. of North Carolina at Chapel Hill.
11:00 Endoplasmic reticulum stress linked to cystic fibrosis
cellular manifestations through PI3-kinase p110alpha/
histone deacetylase 6 signaling cascade.
S.M. Rymut,
D.A. Corey and T.J. Kelley. Case Western Reserve
Univ.
(914.4)
11:15
Role of GADD34 in age-related differences in hyperoxia-
induced stress signaling.
J. Shenberger and Y.M.
Wu. Penn State Col. of Med. and Baystate Children’s
Hosp., Springfield, MA.
(914.9)
11:30 Distinct mechanisms for epithelial cell dysfunction and
lung fibrosis caused by different surfactant protein C
mutations.
S. Mulugeta. Univ. of Pennsylvania Med.
Ctr.
12:00
Modulation of
aENaC mRNA expression under different
stresses: implication of its 3’UTR.
F. Migneault, M.
Pascariu, A. Dagenais and Y. Berthiaume. IRCM,
Montreal.
(914.6)
12:15 Softening of hyperoxia treated alveolar epithelial cells
reduces stretch-induced injury.
K.R. Wilhelm, E.
Roan, M. Gosh and C.M. Waters. Col. of Med., Univ.
of Tennessee Hlth. Sci. Ctr., Memphis and Univ. of
Memphis.
(914.11)
290. CEPS TRAINEE SESSION
Featured Topic
(Sponsored by: APS Comparative and Evolutionary
Physiology Section)
m
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am
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: h. C
ontreras
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s. K
irKton
10:30
Temperature-dependent variation in respiratory patterns
and spiracular control in Rhodnius prolixus.
E.
Heinrich and T. Bradley. Univ. of California, Irvine.
(1149.6)
MONDAY PHYSIOLOGY
80
10:45 Temperature influences CO
2
/pH-sensitivity in locus
coeruleus neurons of the bullfrog, Lithobates
catesbeianus .
J. Santin and L. Hartzler. Wright
State Univ.
(714.12)
11:00 Angiotensin II and developmental cardiovascular-renal
interactions in embryonic chickens.
C.A. Mueller, D.A.
Crossley II and W.W. Burggren. Univ. of North Texas.
(714.18)
11:15 A comparison of the cardiovascular responses to
anemia in digesting Burmese pythons and American
alligators.
C.E. Slay, S. Enok, T. Wang and J.W.
Hicks. Univ. of California, Irvine and Aarhus Univ.,
Denmark.
(714.16)
11:30 Prolonged fasting induces insulin resistance in the
Northern elephant seal pup.
J.A. Viscarra, D.E.
Crocker and R.M. Ortiz. Sch. of Nat. Sci., Univ. of
California, Merced and Sonoma State Univ.
(714.21)
11:45 Prolactin as an osmoregulatory hormone in zebrafish:
transcriptional regulation of a Na
+
/Cl
-
cotransporter in
the gill.
J. Breves, S. Serizier, V. Goffin, S. McCormick
and R. Karlstrom. Univ. of Massachusetts Amherst
and INSERM, Univ. of Paris Descartes.
(714.6)
12:00 Development and plasticity of innate immune function
in altricial house sparrow nestlings.
T.L. Killpack and
W.H. Karasov. Univ. of Wisconsin-Madison. (714.19)
12:15 Development of endothermy in the Pekin duck (Anas
pekin).
S. Ream, A. Duquaine, S.K. Goy Sirsat, T.S.
Sirsat and E.M. Dzialowski. Univ. of North Texas.
(1149.17)
291. MECHANOSENSORY MECHANISMS IN THE
KIDNEY
Symposium
(Sponsored by: APS Renal Section)
m
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am
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Transporters and Ion Channels
10:30 The polycystins and ciliary sensing.
M. J. Caplan. Yale
Univ. Sch. of Med.
11:00 (Hemi)channel-mediated, mechanosensitive ATP
release in the collecting duct.
J. Peti-Peterdi. Univ. of
Southern California.
11:30 Mechanically stimulated nucleotide release in renal
epithelia.
J. Leipziger. Aarhus Univ., Denmark.
12:00
A role for bENaC as a mechanosensor in renal VSMC.
H. A. Drummond. Univ. of Mississippi Med. Ctr.
292. MICROCIRCULATORY SOCIETY YOUNG
INVESTIGATOR SYMPOSIUM
Symposium
(Sponsored by: The Microcirculatory Society)
m
on
. 10:30
am
—B
oston
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onvention
& e
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, 205C
C
haired
: W. l. m
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arDinal
10:30 Aging attenuates spontaneous endothelial Ca
2+
events
with altered perivascular nerve function in mouse
mesenteric arteries in vivo.
E.B. Westcott and S.S.
Segal. Univ. of Missouri-Columbia. (901.3)
10:50 Mechanisms of endothelial dysfunction in penetrating
cerebral arterioles of DOCA-salt hypertensive rats.
P.W. Pires, N. Matin, H. Garver, W.F. Jackson and
A.M. Dorrance. Michigan State Univ. (678.7)
11:10 Functional vasodilation is impaired in arterialized
capillaries following ischemia.
J.P. Cutts, F.
MacGabhann and T. Cardinal. Cal Poly San Luis
Obispo and Johns Hopkins Univ.
(685.21)
11:30 Glucagon-like peptide-1 attenuates agonist-stimulated
cytosolic free calcium ([Ca
2+
]
i
) signaling and the
production of F2
a-isoprostane in endothelial cells.
V.A. Richardson, C.S. Weber, R.M. Lynch and B.B.
Dokken. Univ. of Arizona. (900.5)
11:50
Platelets of humans with type 2 diabetes (DM2) exhibit
fewer prostacyclin receptor (IPR) binding sites as well
as decreased iloprost-mediated cAMP accumulation.
S. Knebel, R. Sprague, M. Ellsworth and A.
Stephenson. Saint Louis Univ. (900.4)
12:00 Discussion.
293. NOVEL ROLES OF HORMONES IN BLOOD
PRESSURE REGULATION
Featured Topic
(Sponsored by: APS Water and Electrolyte Homeostasis
Section)
m
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am
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onvention
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: J. s
ullivan
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J. s
asser
10:30 Sex difference in blood pressure regulation in aging
spontaneously hypertensive rats.
R.O. Maranon, J.
Do Carmo and J.F. Reckelhoff. Univ. of Mississippi
Med. Ctr.
(904.2)
10:45 Ang (1-7) has a greater contribution to the blood
pressure lowering effects of AT1 receptor blockade
in female spontaneously hypertensive rats compared
to males.
M. Zimmerman and J. Sullivan. Georgia
Regents Univ.
(904.3)
11:00 17
b-Estradiol attenuates renal TNFa and the
progression of hypertension in mice with systemic
lupus erythematosus.
E.L. Gilbert, K.W. Mathis and
M.J. Ryan. Univ. of Mississippi Med. Ctr. (904.4)
11:15 Testosterone modulates sodium-regulating hormones
in women with PCOS.
N. Stachenfeld, M.M. Wenner
and H.S. Taylor. John B. Pierce Lab., Yale Sch. of
Med. and Univ. of Delaware.
(904.5)
11:30 Improvement of salt-sensitive hypertension in SS-
Mstnem1Mcwi rats.
D.W. Stepp, R.H. Dunlap and
J.D. Mintz. Georgia Hlth. Sci. Univ. (904.9)
11:45 Targeting of 11
b-hydroxysteroid dehydrogenase type 2
in the nucleus of the solitary tract links salt appetite
and hypertension.
L.C. Evans, C. Kenyon, J. Mullins,
M. Holmes and M. Bailey. Univ. of Edinburgh, U.K.
(904.8)
12:00 Potentiation of angiotensin II (Ang II) hypertension in
rats by sensitizing pre-treatment with intermittent ICV
Ang II injections.
S.C. Clayton, S. Hurley, T. Beltz
and A.K. Johnson. Univ. of Iowa. (904.7)
PHYSIOLOGY MONDAY
81
M
O
N
12:15
Vasopressin increases blood pressure without inducing
pulmonary hypertension in a Sus scrofa model
of hemorrhage.
J. Sarkar, C.F.T. Uyehara, W.M.
Ichimura, L-A.M. Murata, A.K. Sato, C.A. Hernandez
and C.L. Allen. Tripler Army Med. Ctr., HI. (904.10)
294. SOLOMON A. BERSON DISTINGUISHED
LECTURESHIP OF THE APS ENDOCRINOLOGY
AND METABOLISM SECTION
m
on
. 10:30
am
—B
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, 210a
Blood Pressure Regulation
Title: Extra-Nuclear Estrogen Receptors: Functions for
Physiology and Pathophysiology
Speaker:
E. R. Levin. Univ. of California, Irvine.
295. THERAPEUTIC CRANIAL COOLING AND
SELECTIVE BRAIN COOLING IN HUMANS
Symposium
(Sponsored by: APS Environmental and Exercise
Physiology Section)
m
on
. 10:30
am
—B
oston
C
onvention
& e
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C
enter
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C
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: m. W
hite
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C. C
ranDall
10:30
Effects of active and passive heat stress on mechanisms
modulating cerebral perfusion.
C. Crandall. Univ. of
Texas Southwestern Med. Ctr.
10:55 Characteristics of heat-induced hyperventilation in
humans: implications for SBC?
T. Nishiyasu. Univ. of
Tsukuba.
11:20 Cerebral heat balance at rest and during exercise with
hyperthermia.
L. Nybo. Univ. of Copenhagen.
11:45
Avenues of cranial heat exchange and human SBC.
M.
White. Simon Fraser Univ., Canada.
12:10
Therapeutic cranial cooling in humans.
B. Harris. NHS
Lothian and Univ. of Edinburgh.
296. TIGHT JUNCTIONS IN EPITHELIAL
HOMEOSTASIS: BEYOND PARACELLULAR
BARRIER
Featured Topic
(Sponsored by: APS Gastrointestinal and Liver
Physiology Section)
m
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. 10:30
am
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oston
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hen
Transporters and Ion Channels
10:30 Signaling functions of ZO-1.
K. Matter. University Col.
London.
11:00
The dual roles of aromatic residue Y67 in claudin-2 pore
cation selectivity.
J. Li, M. Zhuo, L. Pei and A.S.L.
Yu. Univ. of Kansas Med. Ctr. and Univ. of Southern
California.
(954.1)
11:15 Zonula occludens-1 is required for epithelial
morphogenesis and lumen development.
M.
Odenwald, N.E. Joseph, A.S. Fanning and J.R.
Turner. Univ. of Chicago and Univ. of North Carolina
at Chapel Hill.
(954.10)
11:30 Contributions of occludin to epithelial homeostasis.
L.
Shen. Univ. of Chicago.
12:00 Simulated microgravity increases susceptibility of
intestinal epithelial cells to acetaldehyde-induced
barrier dysfunction.
C.A. Stork, R.R. Marchelletta,
G.K. Prisk and D.F. McCole. UCSD. (954.12)
12:15 Role of zonula occludens in reduced epithelial cell
proliferation by hypertonic stress.
X. Qiao, I. Roth, E.
Feraille and U. Hasler. Univ. of Genva. (954.7)
297. WIGGERS AWARD FEATURED TOPIC: NOVEL
PATHWAYS REGULATING MICROVASCULAR
TONE AND FUNCTION
Featured Topic
(Sponsored by: APS Cardiovascular Section)
m
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am
—B
oston
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onvention
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C
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: D. G
utterman
10:30
Shifting mechanisms of endothelium-dependent dilation
in the human microcirculation.
D. D. Gutterman. Med.
Col. of Wisconsin.
11:00 A novel role for spontaneous endothelial cell calcium
activity in the vascular myogenic response.
P. Bagher,
T. Beleznai, Y. Kansui, R. Mitchell, C.J. Garland and
K.A. Dora. Univ. of Oxford and Kyushu Univ., Japan.
(924.3)
11:15 Abnormal ER and mitochondrial communication
underlies ER stress in cerebrovascular insulin
resistance.
P.V.G. Katakam, I. Rutkai, D. Liu, S.M.
Grovenburg, A.O. Gordon and D.W. Busija. Tulane
Univ. Sch. of Med.
(924.5)
11:30
Involvement of TRPM4 in pressure and agonist-induced
vasoconstriction in the cerebral microcirculation.
Y.
Li, R.L. Baylie and J.E. Brayden. Univ. of Vermont.
(924.6)
11:45 Role of vascular hyperpolarization, nitric oxide, and
prostaglandins in reactive hyperemia in healthy
humans.
A.R. Crecelius, J.C. Richards, G.J.
Luckasen, D.G. Larson and F.A. Dinenno. Colorado
State Univ. and Univ. of Colorado Hlth., Loveland.
(924.1)
12:00
Nitric oxide stress uncovers pM b2-adrenergic mediated
dilation to isoproterenol mimicked by preventing
clathrin endosome formation.
M. Frame, B. Calizo,
A.M. Dewar and S. Scarlata. Stony Brook Univ.
(924.4)
12:15 Endogenously-generated lipid peroxidation products
dilate rat cerebral arteries by activating TRPA1
channels in the endothelium.
M.N. Sullivan, A. Bruhl
and S. Earley. Colorado State Univ. (924.2)
MONDAY PHYSIOLOGY
82
298. EDWARD F. ADOLPH DISTINGUISHED
LECTURESHIP OF THE APS ENVIRONMENTAL
AND EXERCISE PHYSIOLOGY SECTION
m
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pm
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Title: The Remarkable Anti-aging Effects of Aerobic
Exercise on Arteries
Speaker:
D. R. Seals. Univ. of Colorado Boulder.
299. BONE PHYSIOLOGY UNDER ENVIRONMENTAL
STRESS
Symposium
(Sponsored by: APS Comparative and Evolutionary
Biology Section)
m
on
. 3:15
pm
—B
oston
C
onvention
& e
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WerKoWiCz
3:15
Bone as buffer during metabolic acidosis.
D. C. Jackson.
Brown Univ.
3:40
Bone quality in lactating mammals and their offspring.
W. R. Hood. Auburn Univ.
4:05
Bone protection during inactivity: strategies of small and
large hibernators.
S. W. Donahue. Colorado State
Univ.
4:30
Temperature effects on the growth plate and its
vasculature.
M. A. Serrat. Marshall Univ.
4:55
Atmospheric oxygen effects bone vascularity, growth
and biomechanics.
T. Owerkowicz. California State
Univ., San Bernardino.
300. CARL W. GOTTSCHALK DISTINGUISHED
LECTURESHIP OF THE APS RENAL SECTION
m
on
. 3:15
pm
—B
oston
C
onvention
& e
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C
enter
, 210a
Title: Regulation of Renal Urea Transport
Speaker:
J. Sands. Emory Univ. Sch. of Med.
301. CENTRAL NERVOUS SYSTEM MODULATION
OF CARDIORESPIRATORY RESPONSES TO
HYPOXIA
Featured Topic
(Sponsored by: APS Hypoxia Group)
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pm
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oston
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: i. s
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Hypoxia and Oxidative Stress
Central Control of Homeostasis
3:15
Modulation of centrally-mediated hypoxic respiratory
excitation.
I. C. Solomon. Stony Brook Univ.
3:45
Role of brainstem serotonergic neurons and receptors in
mediating the cardiorespiratory responses to hypoxia.
D. Mendelowitz. George Washington Univ. Med. Ctr.
4:15
Central modulation of arterial chemo-baroreflex control
by propofol during severe arterial hypoxia in the
rabbit.
A.W. Quail, D.B. Cottee, R. Roach and S.W.
White. Univ. of Newcastle and Hunter Med. Res. Inst.,
Australia.
(1135.3)
4:30
Knockdown of tyrosine hydroxylase in the nucleus of
the solitary tract reduces elevated blood pressure
during chronic intermittent hypoxia.
C.S. Bathina, A.
Rajulapati, M. Franzke, K. Yamamoto and S. Mifflin.
Univ. of North Texas Hlth. Sci. Ctr.
(1135.4)
4:45
Endogenous hydrogen sulfide in the rostral ventrolateral
medulla mediates ventilatory response induced by
hypoxia.
A.F. Donatti, M. Kwiatkoski, R.N. Soriano,
E.C. Carnio and L.G.S. Branco. Univ. of São Paulo,
Ribeirão Preto.
(1135.12)
5:00
Developmental hyperoxia attenuates hypoxic ventilatory
depression in neonatal rats.
R.W. Bavis, S.H.
Grandgeorge and C.B. Hill. Bates Col. (1135.10)
302. GASTRIC CONTROL OF APPETITE AND
ENERGY METABOLISM
Symposium
(Sponsored by: APS Neural Control and Autonomic
Regulation Section)
m
on
. 3:15
pm
—B
oston
C
onvention
& e
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C
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, 206a
C
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: W. z
hanG
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aChe
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