1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

Blood Pressure Regulation

Translational Physiology

8:00 Introduction. 

P. Marvar. Emory Univ.

8:10 

Brain angiotensin II and cardiovascular reactivity to 

stress: what animal models tell us about the link. 

D. N. 

Mayorov. Univ. of Melbourne.

8:35 

Early life stress and cardiovascular disease risk in 

adulthood. 

J. Pollock. Georgia Regents Univ.

9:00 

Depression and cardiovascular disease: influence of 

social stressors in prairie voles. 

A. Grippo. Northern 

Illinois Univ.

9:20 

Treatments for depression in cardiac patients: what 

works and what doesn’t. 

J. A. Blumenthal. Duke 

Univ.

9:40 

Cerebral vascular consequences of prenatal stress. 

G. 

N. Neigh. Emory Univ.

494.  NUTRIENTS AND CARDIOVASCULAR HEALTH 

AND DISEASE: GLUCOSE, FATTY ACIDS AND 

BEYOND

Featured Topic

(Sponsored by: APS Cardiovascular Section)

W

eD

. 8:00 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 212

C

haired

: J. C. C

hatham

 

anD

 s. a. m

arsh

Metabolic Diseases

Translational Physiology

8:00 

Role of glutamine in regulation of myocardial substrate 

utilization: anaplerosis and beyond. 

C. Des Rosiers. 

Univ. of Montreal, Montreal Heart Inst. Res. Ctr.

8:30 

Ketone body metabolism in cardiovascular health and 

disease. 

P. Crawford. Washington Univ. Sch. of Med.

9:00  Exploring mechanisms that attenuate myocardial 

glucose uptake in response to acute hyperglycemia: 

identification of a vicious metabolic cycle. 

D. Joseph, 

C.P. Kimar and M.F. Essop. Stellenbosch Univ., 

South Africa. 

(1192.8)

9:15 Nf-

kB dependent mechanisms of high fat mediated 

cardioprotection. 

L. Haar, X. Ren, N. Bertaux-Skeirik, 

T. Tee, M. Tranter and W.K. Jones. Univ. of Cincinnati. 

(1192.10)

9:30 

Glutathione peroxidase-4 plays a critical role in protection 

from metabolic syndrome and cardiac remodeling 

caused by diet-induced obesity. 

L.A. Katunga, T.A. 

Mattox, S.M. Abernathy, T.M. Darden, J. Virag and 

E.J. Anderson. East Carolina Univ. (1192.23)

9:45 

Chronic interval exercise modifies the myocardial lipid 

profile in a miniature swine model of heart failure with 

preserved ejection fraction. 

C.A. Emter, R.S. Rector, 

C.P. Baines, K.D. Ford and D.A. Ford. Truman VA 

and Univ. of Missouri-Columbia and Saint Louis Univ. 

(1192.14)

495.  NEW INSIGHTS ON THE CELLULAR CA

2+

 

MECHANISMS

Symposium

(Sponsored by: ALACF — Association of Latin American 

Physiological Societies)

W

eD

. 8:00 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 206B

C

haired

: B. m

aChaDo

 

anD

 r. i

turriaGa

8:00 

Nuclear calcium signaling: a cell within a cell. 

M. F. Leite. 

Fed. Univ. of Minas Gerais, Brazil.

8:30 

Calcium handling pathways in Leydig cells. 

W. Varanda. 

Univ. of São Paulo.

WEDNESDAY PHYSIOLOGY

136

9:00 

Calcium signals that regulate gene expression in striated 

muscle: How can they be distinguishable from those 

involved in contraction? 

E. Jaimovich. Univ. of Chile.

9:30  Calcium-calmodulin dependent kinase II (CaMKII) 

signaling in cardiac apoptosis and arrhythmias. 

M. 

Vila Petroff. Natl. Univ. of La Plata, Argentina.

496.  THE STUDY OF INJURY AND REPAIR IN 

MULTIPLE ORGAN SYSTEMS: SERENDIPITY IN 

TRANSLATIONAL RESEARCH

Symposium

(Sponsored by: American Federation for Medical 

Research)

W

eD

. 8:00 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 205B

C

haired

: r. F

reishtat

 

anD

 e. h. l

o

Translational Physiology

8:00 

Serendipity in the lung: dyssynchronous mitosis and 

inflammation in asthmatic epithelium. 

R. J. Freishtat. 

Children’s Natl. Med. Ctr., Washington, DC.

8:20 

Serendipity in time: transitions from injury into repair 

after stroke. 

E. H. Lo. Massachusetts Gen. Hosp., 

Harvard Med. Sch.

8:40 

Serendipity in the brain: isoflurane is neuroprotective in 

neonatal hypoxia-ischemia encephalopathy rat model 

by activation of opioid receptors. 

J. Zhang. Loma 

Linda Med. Sch.

9:00 

Serendipity in the blood: mass spectrometry in the 

discovery of clinical biomarkers. 

M. Lopez. Thermo-

Fisher Scientific.

9:20 

Serendipity in the heart: functional characterization of 

cardiac proteosomes in myocardial ischemic injury. 

P. 

Ping. UCLA Med. Ctr.

9:40 

Expert panel discussion. How chance favors the 

prepared mind.

497.  EVOLUTION VIEWED THROUGH THE LENS OF 

CELL SIGNALING

Symposium

(Sponsored by: APS Comparative and Evolutionary 

Physiology Section)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 212

C

haired

: J. s. t

orDay

 

anD

 n. B

laCKstone

Physiology of Development

10:30 

The mechanism of epithelial polarization in Dictyostelium 

and the origin of metazoan multicellularity. 

W. Weis. 

Stanford Univ.

11:00  Why invent yet another junctional complex to become 

a metazoan? 

A. Le Bivic. Inst. for Develop. Biol., 

Marseille.

11:30  Cell signaling from mitochondria to metazoa. 

N. 

Blackstone. Northern Illinois Univ.

12:00 

Cell signaling is all of biology. 

J. S. Torday. UCLA.

498.  EXTRINSIC AND INTRINSIC MECHANISMS 

UNDERLYING MYOCARDIAL DYSFUNCTION 

AND HEART FAILURE

Symposium

(Sponsored by: APS Cardiovascular Section)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 205B

C

haired

: F. s

heiKh

 

anD

 v. m

ezzano

Inflammation and Immune Responses

Translational Physiology

10:30  Mechanisms linking air pollution to myocardial 

dysfunction. 

L. Wold. Nationwide Children’s Hops., 

The Ohio State Univ.

11:00  Estrogen and cardiovascular dysfunction and disease. 

A. Knowlton. Univ. of California, Davis and Northern 

California VA Med. Ctr.

11:30 Dynamics of fibroblast-myocyte-endothelial cell 

interactions in myocardial function and disease. 

T. 

Baudino. Texas A&M Hlth. Sci. Ctr.

12:00  Defining new mechanisms regulating the cardiac 

muscle molecular machinery in myocardial function 

and disease. 

F. Sheikh. UCSD.

499.  OXIDATIVE STRESS-INDUCED ENDOTHELIAL 

CELL REPROGRAMMING

Symposium

(Sponsored by: APS Respiration Section)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 211

C

haired

: r. D. m

inshall

 

anD

 n. v

oelKel

Hypoxia and Oxidative Stress

10:30  Complexities of lung vascular remodeling and the 

phenotypic options of endothelial cells. 

N. Voelkel. 

Virginia Commonwealth Univ.

11:00  New face of RNS biology: role of nitrate-nitrite-NO 

signaling pathway in endothelial function and 

pulmonary hypertension. 

M. Gladwin. Univ. of 

Pittsburgh Med. Ctr.

11:30 

Role of PTEN and Cav-1 depletion in eNOS dysfunction 

and EC reprogramming. 

M. Bonini. Univ. of Illinois 

Hosp. & Hlth. Sci. Syst.

12:00  Metabolic shift of pulmonary hypertensive endothelial 

cells. 

R. Tuder. Univ. of Colorado Denver, Anschutz 

Med. Campus.

PHYSIOLOGY WEDNESDAY

137

W

E

D

500.  PROMETHEUS UNPLUGGED: BASIC 

MECHANISMS OF LIVER REGENERATION

Symposium

(Sponsored by: APS Gastrointestinal and Liver 

Physiology Section)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 208

C

haired

: u. a

pte

 

anD

 G. K. m

iChalopoulos

10:30  Mechanisms of liver regeneration after partial 

hepatectomy. 

G. K. Michalopoulos. Univ. of 

Pittsburgh Sch. of Med.

11:00  Mechanisms of liver regeneration after chemical-

induced liver injury. 

U. Apte. Univ. of Kansas Med. Ctr.

11:30 Mechanisms of mitogen-induced hepatocyte 

proliferation. 

J. Locker. Albert Einstein Col. of Med.

12:00 

Hepatic stem cells. 

H. Willenbring. UCSF.

501.  RECENT ADVANCES IN UNDERSTANDING 

MECHANISMS REGULATING BREATHING 

DURING EXERCISE

Symposium

(Supported by an educational grant from The 

Physiological Society, Journal of Physiology)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 210a

C

haired

: h. v. F

orster

 

anD

 J. D

empsey

10:30  Defining the circuitry of central command during 

exercise: use of functional neurosurgery. 

D. Paterson. 

Univ. of Oxford.

11:00  The fast exercise drive to breathe. 

J. Duffin. Univ. of 

Toronto, Thornhill Res. Inc.

11:30  Muscle vasodilation in exercise: a prerequisite for 

arterial PCO2 homeostasis. 

P. Haouzi. Penn State.

12:00  Are muscle afferents required for a normal exercise 

hyperpnea? 

J. Dempsey. Univ. of Wisconsin-Madison.

502.  REGULATION OF EPITHELIAL TRANSPORT 

PROCESSES VIA POSTTRANSLATIONAL 

MODIFICATIONS

Symposium

(Sponsored by: APS Epithelial Transport Group)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 206B

C

haired

: J. D. K

lein

 

anD

 K-J. K

im

Transporters and Ion Channels

10:30 

Regulation of calcium-activated potassium channels by 

S-acylation. 

M. J. Shipston. Univ. of Edinburgh.

11:00  Multi-site phosphorylation as a key regulation of 

membrane protein function. 

R. Fenton. Aarhus Univ., 

Denmark.

11:30 

Regulation of the epithelial Na

+

 channel by the ubiquitin 

ligase Nedd4-2. 

D. Rotin. The Hosp. for Sick Children, 

Toronto.

12:00 

Role of sumoylation in regulation of potassium channels. 

S. A.N. Goldstein. Univ. of Chicago.

503.  THE ROLE OF AKT/MTOR PATHWAY IN MUSCLE 

GROWTH AND REJUVENATION

Featured Topic

(Sponsored by: APS Muscle Biology Group)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 209

C

haired

: C. s

teenBerGen

 

anD

 z. C

ai

10:30 

Stem cells in the regulation of Akt/PTEN pathway in the 

heart failure. 

D. Singla. Univ. of Central Florida.

11:00  Myocardial regeneration promoted by late remote 

ischemic preconditioning through the IL-10/Akt 

signaling pathway. 

Z. Cai. Johns Hopkins Univ. Sch. 

of Med.

11:30 

Akt/mTOR signaling, autophagy in myocardial aging. 

J. 

Ren. Univ. of Wyoming.

11:45  Raptor activation by aldosterone promotes apoptosis 

resistance in pulmonary artery smooth muscle 

cells to modulate adverse pulmonary vascular 

remodeling in pulmonary arterial hypertension. 

R. 

Aghamohammadzadeh, A. Heagerty, J. Loscalzo, 

B.A. Maron and J.A. Leopold. Brigham and Women’s 

Hosp., Harvard Med. Sch. and British Heart Fndn., 

Univ. of Manchester. 

(1199.1)

12:00 Alterations in the AKT/mTOR pathway in 

dystroglycanopathy muscle. 

S.J. Foltz and A.M. 

Beedle. Univ. of Georgia. (1199.4)

12:15 

Molecular basis for anabolic resistance in disuse atrophy 

of skeletal muscle. 

A.R. Kelleher, S.R. Kimball, M.D. 

Dennis, R.J. Schilder and L.S. Jefferson. Penn 

State Col. of Med. 

(1199.3)

504.  SEX-BASED DIFFERENCES IN EXERCISE 

METABOLISM

Symposium

(Sponsored by: APS Environmental and Exercise 

Physiology Section)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 206a

C

haired

: s. p

hillips

 

anD

 m. t

arnopolsKy

10:30 Sex-based differences in protein metabolism. 

 

B. Mittendorfer. Washington Univ.

11:00  Sex-based differences in adipose tissue metabolism.  

M. Tarnopolsky. McMaster Univ., Canada.

11:30  The influence of sex in metabolism during exercise 

recovery. 

G. Henderson. Rutgers Univ.

12:00  Adaptations to exercise training in men and women.  

S. Phillips. McMaster Univ., Canada.

WEDNESDAY PHYSIOLOGY

138

505.  TRANSLATIONAL RESEARCH: FROM BENCH 

TO BEDSIDE

Symposium

(Sponsored by: APS Trainee Advisory Committee)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 207

C

haired

: a. W

hitaKer

 

anD

 J. B

raDley

Translational Physiology

10:30  M.D.’s perspective on translational science career. 

 

M. Joyner. Mayo Clin.

11:00 

Basic science researcher’s perspective on translational 

science career. 

B. LaMarca. Univ. of Mississippi Med.

Ctr.

11:30 Defining 

Translational Science. 

J. Rutter. NIDA, NIH.

12:00 

General discussion.

506.  WILLIAM BEAUMONT: AMERICA’S 

FIRST PHYSIOLOGIST AND PIONEER OF 

GASTROINTESTINAL RESEARCH

Symposium

(Sponsored by: APS History of Physiology Group and 

Gastrointestinal and Liver Physiology Section)

W

eD

. 10:30 

am

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 205C

C

haired

: J. B. D

ean

 

anD

 K. l. r

yan

10:30  The gunshot heard ‘round the world’! Dr. William 

Beaumont, the inquisitive doctor, and Alexis St. 

Martin, his reluctant patient. 

J. B. Dean. Univ. of South 

Florida Morsani Col. of Med.

11:00 

William Beaumont and the scientific basis for the brain-

gut axis. 

R. Rogers. Pennington Biomed. Res. Ctr.

11:30  William Beaumont: experiments on exercise and 

digestion and their impact. 

G. P. Lambert. Creighton 

Univ.

12:00 

General discussion.

507.  THE AGING CARDIOVASCULAR SYSTEM: 

STRUCTURAL REMODELING IN HEALTH AND 

DISEASE

Featured Topic

(Sponsored by: APS Cardiovascular Section)

W

eD

. 2:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 206B

C

haired

: m. l. h

orn

 

anD

 G. l. p

ierCe

Hypoxia and Oxidative Stress

Translational Physiology

2:30 

The role of SPARC in myocardial collagen processing 

and deposition in aging and disease. 

A. D. Bradshaw. 

Med. Univ. of South Carolina.

3:00 

Overexpression of Mn superoxide dismutase attenuates 

age related up-regulation of TGF-

b and remodeling 

in the aging heart. 

Y. Lee, H-B. Kwak, J-H. Kim, H. 

Van Remmen, A. Richardson and J.M. Lawler. 

Texas A&M Univ., Inha Univ., South Korea, Univ. of 

Minnesota Med. Sch. and Univ. of Texas Hlth. Sci. Ctr. 

at San Antonio. 

(1194.1)

3:15 

Diverse effects of aging on the cardiac response 

in pathological left ventricular remodeling and 

dysfunction. 

M. de Boer, E.D. van Deel, M. de 

Kleijnen, J.H.J. Hoeijmakers and D.J. Duncker. 

Univ. Med. Ctr. Rotterdam, Netherlands. 

(1194.2)

3:30 

Molecular mechanisms of aortic wall stiffness and 

remodeling in aging and disease. 

E. G. Lakatta. NIA, 

NIH.

4:00 

Aortic stiffening as a result of reduced elastin content 

leads to cerebral artery dysfunction. 

A.E. Walker, 

G.D. Henson, K.D. Reihl, C. Bramwell, D.Y. Li, L.A. 

Lesniewski and A.J. Donato. Univ. of Utah. (1194.3)

4:15 

Perivascular adipose tissue contributes to large elastic 

artery stiffness with aging and is associated with 

greater superoxide bioavailability. 

B.S. Fleenor, J.S. 

Eng, B.T. Pham, J.D. Kloor and D.R. Seals. Univ. of 

Colorado Boulder and Univ. of Kentucky. 

(1194.4)

508.  CELL-BASED THERAPY FOR THE HEART AND 

KIDNEY: FROM BENCH TO BEDSIDE

Symposium

(Sponsored by: APS Translational Physiology Group)

W

eD

. 2:30 

pm

—B

oston

 C

onvention

 & e

xhiBition

 C

enter

, 205C

C

haired

: a. r. C

haDe

 

anD

 D. p. B

asile

Translational Physiology

2:30 

Progenitor cells and the heart. 

D. W. Losordo. 

Northwestern Univ., Chicago.

3:00 

Progenitor cells and the kidney. 

L. O. Lerman. Mayo 

Clin. Col. of Med.

3:30 

Beneficial effects of angiotensin (1-7) on dysfunctional 

CD34

+

 endothelial progenitor cells from patients with 

heart failure. 

S. Hazra, C.T. Cole-Jeffrey, C.J. Pepine, 

M.J. Katovich, M.B. Grant and M.K. Raizada. Univ. 

of Florida. 

(1147.1)

3:45 

Mesenchymal stem cells attenuate renal inflammation, 

microvascular rarefaction and fibrosis in the 

renovascular hypertension rat model. 

M.A. Boim, 

E.B. Oliveira-Sales, E. Maquigussa, P. Semedo, 

L.G. Pereira, N.O. Camara, C.T. Bergamaschi and 

R.R. Campos. Fed. Univ. of São Paulo. (1147.2)

4:00 

Renal regeneration in diabetic nephropathy.