1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

B. German. Univ. of California, Davis.

464.  ASSESSING U.S. SODIUM INTAKE THROUGH 

DIETARY DATA AND URINE BIOMARKERS

Symposium

(Sponsored by: Medical Nutrition Council)

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oGsWell

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oria

Global and Public Health Nutrition

10:30 

Estimating 24-hour urinary sodium excretion from casual 

(“spot”) urinary sodium concentration in Western 

populations: data from INTERSALT. 

P. Elliott. Imperial 

Col. of London.

10:54  A calibration study assessing sodium and related 

micronutrient status from timed-spot and 24-hour 

urines: design and initial findings. 

C-Y. Wang. Natl. 

Ctr. for Hlth. Stats., Hyattsville, MD.

461.  LIFE COURSE EPIDEMIOLOGY IN NUTRITION 

AND CHRONIC DISEASE RESEARCH: A TIMELY 

DISCUSSION

Symposium

(Sponsored by: Nutritional Epidemiology RIS)

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Research Methods and Funding

8:00 

Brief overview of life course epidemiology, importance 

of topic and introduction of speakers. 

N. Parekh. NYU.

8:10 

Preventing common chronic health conditions – starting 

at the earliest stages of human development. 

M. 

Gillman. Harvard Univ.

8:35 

Early-life nutritional exposures and risk of breast 

cancer: changes in DNA methylation as a possible 

mechanism. 

J. Freudenheim. Univ. at Buffalo.

9:00 

The pubertal period as a window of cancer susceptibility. 

E. Bandera. Cancer Inst. of NJ, UMDNJ-Robert Wood 

Johnson Med. Sch.

9:25 

Cutting edge statistical methods for a life course 

approach. 

K. Bub. Auburn Univ.

9:50 

Research gaps and existing cohorts for life course 

epidemiology research. 

N. Potischman. NCI, NIH.

462.  DIETARY PHOSPHORUS EXCESS A RISK 

FACTOR IN CHRONIC BONE, KIDNEY AND 

CARDIOVASCULAR DISEASE

Symposium

(Supported by an educational grant from the American 

Society of Nephrdogy)

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riBarri

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oChaired

: m.s. C

alvo

Clinical Nutrition

8:00 

Phosphorus content of the US food supply: Issues and 

considerations. 

M. S. Calvo. USDA.

8:24 

Excess dietary phosphorus intake and chronic kidney 

disease. 

J. Uribarri. Mount Sinai Sch. of Med.

8:48 

Effects of dietary phosphorus excess on bone health. 

E. 

Takeda. Univ. of Tokushima, Japan.

9:12  Factors affecting high phosphorus intake and 

cardiovascular disease risk. 

O. Gutierrez. Univ. of 

Alabama at Birmingham.

9:36 

Strategies to assess the usual phosphorus intake in 

population studies. 

K. L. Tucker. Northeastern Univ.

NUTRITION WEDNESDAY

129

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11:18 

Validity of predictive equations for 24-hour urine sodium 

excretion in adults aged 18-39 years. 

M. E. Cogswell. 

Ctrs. for Dis. Control and Prevent.

11:42  Accuracy of the U.S. Department of Agriculture 

automated multiple-pass method for assessing 

population sodium intake. 

D. G. Rhodes. USDA, 

Beltsville.

12:06  Assessment of changes in sodium excretion in the 

United States between 1988 and 2010 using spot 

(casual) urine samples. 

C. M. Pfeiffer. Ctrs. for Dis. 

Control and Prevent.

465.  YOGURT WORKSHOP: THE ECONOMICS OF 

DAIRY AND YOGURT IN NUTRITION

Workshop

(Supported by an educational grant from Danone 

Nutrition Institute International)

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D. McCarron. Univ. of California, Davis.

466.  YOGURT WORKSHOP: YOGURT,  LIVING 

CULTURES AND GUT HEALTH

Workshop

(Supported by an educational grant from Danone 

Nutrition Institute International)

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D. Savaiano. Purdue Univ.

467.  YOGURT AND BONE HEALTH

Workshop

(Supported by an educational grant from Danone 

Nutrition Institute International)

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R. Rizzoli. Univ.of Geneva.

468.  YOGURT AND FORTIFICATION BENEFITS TO 

SPECIFIC POPULATIONS

Workshop

(Supported by an educational grant from Danone 

Nutrition Institute International)

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S. Meydani. Tufts Univ.

Pathology

469.  BIOMECHANICAL FORCES AND THE 

PATHOPHYSIOLOGY OF THE VASCULAR WALL

Symposium

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arCia

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arDena

 

anD

 F.W. l

usCinsKas

Vascular Biology

8:30 

Shear stress inhibition of sprouting and intussusceptive 

angiogenseis during development. 

E. Jones. McGill 

Univ.

9:15 

Molecular mechanisms of mechanotransduction. 

J. A. 

Frangos. La Jolla Bioengin. Inst.

9:55 

469.1 

Fluid shear stress induces the clustering of 

heparan sulfate via mobility of glypican-1 in lipid rafts. 

Y. Zeng, E. Ebong, V. Rizzo and J. Tarbell. City Col. 

of New York, Albert Einstein Col. of Med. and Temple 

Univ. Sch. of Med.

10:10  Role of mechanosensitive genes in atherosclerosis. 

H. 

Jo. Emory/Georgia Tech.

10:50 

Pharmacomimetics of atheroprotective flow. 

G. Garcia-

Cardena. Harvard Med. Sch.

470.  INNATE IMMUNITY IN LUNG PATHOLOGY

Symposium

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Pulmonary Pathobiology

Inflammation

8:30 

Regulation of innate immunity in the lung post-stem cell 

transplantation. 

B. B. Moore. Univ. of Michigan Med. 

Sch.

9:15 

Regulation of lung mucosal injury and inflammation by 

resolvins. 

B. D. Levy. Harvard Med. Sch., Brigham 

and Women’s Hosp.

10:00  Modulation of innate immune signaling by reactive 

oxygen species. 

T. S. Blackwell. Vanderbilt Univ. 

Med. Ctr.

10:45 

Epithelial-dendritic cell crosstalk in airway inflammation: 

antagonistic effects of SP-D and TSLP. 

A. Haczku. 

Univ. of Pennslyvania.

WEDNESDAY NUTRITION/PATHOLOGY 

130

471.  MOLECULAR AND GENETIC INTERACTIONS IN 

CANCER PATHOGENESIS

Minisymposium

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iCharDson

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astronovo

 

anD

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elGaDo

Neoplasia

8:30 

471.1 

The role of wnt/

b-catenin signaling in regulating 

angiogenesis in hepatocellular carcinoma. 

E.R. Delgado, R. 

Bahal, D. Ly and S.P.S. Monga. Univ. of Pittsburgh, Yale Univ. 

and Carnegie Mellon Univ.

8:50 

471.2 

HMGA2 inhibits apoptosis through interaction 

with ATR/CHK1 signaling complex in human cancer cells. 

S. Natarajan, S. Hombach-Klonisch, P. Droege and T. 

Klonisch. Univ. of Manitoba and Sch. of Biol. Sci., Nanyang 

Technol. Univ., Singapore.

9:10 

471.3 

Pituitary homeobox 2 protects renal cancer cell 

lines against doxorubicin toxicity by transcriptional activation of 

the multidrug transporter ABCB1. 

W-K. Lee, P.K. Chakraborty 

and F. Thévenod. Univ. of Witten/Herdecke, Germany.

9:30 

471.4 

Development of model systems for analysis 

of effects of cell-cell and cell-microenvironment interactions 

on pH regulatory proteins in breast cancer. 

A.P. Andersen, 

L. Ronnov-Jessen, A. Hulikova, P. Swietach and S.F. 

Pedersen. Univ. of Copenhagen and Univ. of Oxford.

9:50 

471.5 

Regulation of the Na

+

,HCO

3

-

 cotransporter 

NBCn1 (SLC4A7) by a constitutively active ErbB2 receptor 

in MCF-7 breast cancer cells. 

A. Gorbatenko, C. Olesen, E. 

Valen and S.F. Pedersen. Univ. of Copenhagen and Harvard 

Univ.

10:10 

471.6 

A novel interplay between AR and DAX-1 

controls aromatase expression in estrogen-dependent cancers. 

M. Lanzino, P. Maris, R. Sirianni, I. Barone, A. Chimento, 

C. Giordano, C. Morelli, G.E. Trombino, D. Bonofiglio, S. 

Catalano and S. Andò. Univ. of Calabria, Italy.

10:30 

471.7 

Aromatase inhibitor resistance in breast cancer: 

a potential role for cytokine signaling network. 

I. Barone, L. 

Gelsomino, C. Giordano, M. Lanzino, D. Bonofiglio, S.A.W. 

Fuqua, S. Catalano and S. Andò. Univ. of Calabria, Italy and 

Baylor Col. of Med.

10:50 

471.8 

RNAseq analysis of FFPE radical 

prostatectomy specimens identifies predictors of biochemical 

recurrence. 

C.S. Moreno, Q. Long, S. Sannigrahi, J. Xu, B.A. 

Johnson, W. Zhou, R.K. Nam, A. Seth, T.W. Gillespie, A.O. 

Osunkoya and J.A. Petros. Emory Univ. and Univ. of Toronto.

11:10 

471.9 

The metabolic fingerprints of prostate cancer. 

C. Priolo, S. Pyne, J. McDunn, J. Rose, E. Ravasz, G. Zadra, 

C. Photopoulos, N. Scaglia, A. DeMarzo and M. Loda. 

Dana-Farber Cancer Inst., Harvard Med. Sch., Metabolon Inc., 

Durham, NC, Beth Israel Deaconess Med. Ctr., Johns Hopkins 

Univ. and Brigham and Women’s Hosp.

11:30 

471.10  Transforming growth factor-beta-induced 

protein ig-h3 is essential for the formation of human colorectal 

carcinoma liver metastasis in vivo. 

V. Castronovo, A. Blomme, 

D. Delvaux, P. Delvenne, O. Detry and A. Turtoi. Univ. of 

Liege and Univ. Hosp. Liege, Belgium.

Pharmacology and Experimental Therapeutics

472.  NORMAN WEINER LECTURE

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The Norman Weiner Lecture is given in alternate years in 

memory of Dr. Norman Weiner, former Chair of the Department 

of Pharmacology at the University of Colorado, and past ASPET 

President. Dr. Weiner suffered a debilitating stroke while chairing 

an ASPET meeting during his Presidential year but continued to 

faithfully attend ASPET meetings until shortly before his death in 

2009. Because of Dr. Weiner’s breadth of interest in pharmacology, 

each of ASPET’s Divisions is asked to submit nominations for 

the lectureship. Dr. David Clapham was selected to give the third 

Weiner lecture for his pioneering work on ion channels, and TRP 

channels in particular.

8:30 Introduction. 

A. Terzic. Mayo Clin.

8:35 

Novel ion channels and their regulation. 

D. E. Clapham. 

Boston Children’s Hosp., HHMI, Harvard Med. Sch.

473.  NEW ROLES FOR SIGNALING BY G PROTEIN 

BETA/GAMMA SUBUNITS

Symposium

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mrCKa

9:30 

Pharmacological targeting of G

bg subunits: mechanisms 

and outcomes. 

A. V. Smrcka. Univ. of Rochester Sch. 

of Med.

10:00  Translocation of G

bg subunits to subcellular 

compartments. 

N. Gautam. Washington Univ. Sch. of 

Med.

10:30 

Distinct roles for individual G

bg isoforms in neurological 

signaling circuits. 

J. Robishaw. Weis Ctr. for Res., 

Danville, PA.

11:00  Scaffolding of G

bg by WD40 repeat proteins. S. Chen. 

Univ. of Iowa.

11:30  G protein 

bg subunits in regulating trafficking and 

assembly of signaling complexes. 

T. Hébert. McGill 

Univ.

PATHOLOGY/PHARMACOLOGY  

WEDNESDAY

131

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474.  APOLIPOPROTEIN E: A PROTEIN AT 

THE INTERSECTION OF VASCULAR AND 

NEURODEGENERATIVE DISEASE BIOLOGY

Symposium

(Sponsored by: The Division for Neuropharmacology and 

Cardiovascular Pharmacology)

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ellinGton

 

anD

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ooD

9:30 

Vascular contributions to the pathogenesis of Alzheimer’s 

disease. 

R. Mayeaux. Columbia Univ. Med. Ctr.

10:05 

ApoE isoform-specific ApoE/A

b complex levels: potential 

mechanism(s) for AD risk, novel AD biomarker and 

therapeutic target. 

M. J. LaDu. Univ. of Illinois at 

Chicago.

10:40  Molecular basis for differential effects of apolipoprotein 

E isoforms on lipoprotein metabolism. 

M. C. Phillips. 

Univ. of Pennsylvania Sch. of Med.

11:15  From concussion to dementia: a key role for 

apolipoprotein E in the central nervous system. 

C. 

Wellington. Univ. of British Columbia.

11:50  Roundtable discussion. 

M. Wood. AstraZeneca 

Pharmaceut.

475.  PHARMACOLOGICAL ENHANCEMENT OF 

WAKEFULNESS

Symposium

(Sponsored by: The Divisions for Behavioral 

Pharmacology; Integrative Systems, Translational and 

Clinical Pharmacology; and Neuropharmacology)

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itKin

9:30 

Chair’s introduction.

9:35 

Introduction to wake promotion. 

D. M. Edgar. Eli Lilly 

and Co.

10:05  Physiological control systems for wakefulness. 

L. De 

Lecea. Stanford Univ.

10:30  Modafanil (Provigil) as a wake-promoting agent. 

J. L. 

Vaught. Former CSO/Exec.VP Cephalon.

11:05 

Histamine H3 receptor inverse agonisim. 

J-C. Schwartz. 

Bioprojet.

11:35  Metabotropic glutamate receptors as targets for wake 

promotion. 

K. A. Wafford. Eli Lilly and Co.

476.  SIGNALS ACTIVATING PANCREATIC STEM 

CELLS AND BETA CELL REGENERATION

Symposium

(Sponsored by: The Divisions for Integrative Systems, 

Translational and Clinical Pharmacology and Molecular 

Pharmacology)

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am

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ilKie

9:30 

Integrated pathways for type 2 diabetes from mouse 

genetics and genomics. 

A. Attie. Univ. of Wisconsin-

Madison.

9:55 

Small molecule screens in beta cell lines for beta cell 

expansion. 

B. Wagner. Broad Inst. of Harvard and 

MIT.

10:20 

Mapping the specific neuronal connections between the 

central nervous system and the endocrine pancreas. 

C. J. Rhodes. Univ. of Chicago.

10:45 

hESCs and iPSCs differentiation to pancreatic endocrine 

lineage. 

S. Chen. Weill Cornell Med. Col.

11:10  GPCR signaling: RGS biomarkers for pancreas 

development, cancer and diabetes. 

T. Wilkie. Univ. of 

Texas Southwestern Med. Ctr.

11:35  Pancreatic stem and progenitor cell niche: pancreatic 

organogenesis throughout life. 

L. M. Reid. Univ. of 

North Carolina at Chapel Hill.

477.  THE PHARMACOLOGY OF NATURAL 

PRODUCTS

Symposium

(Sponsored by: The Divisions for Behavioral 

Pharmacology; Drug Discovery and Development; Drug 

Metabolism; Integrative Systems, Translational and 

Clinical Pharmacology; and Toxicology)

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anD

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illiamson

9:30 Introduction. 

J. S. Williamson. NCCAM, NIH.

9:40 

Cranberry: role in prevention of bacterial adhesion. 

A. 

Howell. Rutgers, the State Univ. of New Jersey.

10:00  Novel pro-resolving mechanisms and omega-3 fatty 

acids. 

C. N. Serhan. Brigham and Women’s Hosp., 

Harvard Med. Sch.

10:20  Natural product’s potential for drug abuse treatment. 

D.Y. W. Lee. Harvard Med. Sch.

10:40  Pharmacological effects of cacao flavanols: from 

receptors to clinical endpoints. 

F. Villarreal. UCSD 

Sch. of Med.

11:00  Prevention of estrogen carcinogenesis by botanical 

dietary supplements for women’s health. 

J. L. Bolton. 

Univ. of Illinois at Chicago.

11:20 

Panel Discussion (Questions for Speakers and NCCAM). 

J. Glowa. NCCAM, NIH.

478.  THE 5-HT2C RECEPTOR: A NEW TARGET FOR 

MULTIPLE THERAPEUTICS

Symposium

(Sponsored by: The British Pharmacological Society and 

the ASPET Divisions for Molecular Pharmacology and 

Neuropharmacology)

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9:30  A bioinformatics approach to 5-HT2C receptor 

modulation of behavioral patterns. 

L. Tecott. UCSF.

10:05  The effect of Htr2c post-transcriptional modifcation on 

5-HT2C receptor-regulated behavior. 

A. Isles. Cardiff 

Univ. Sch. of Med.

10:40  A novel treatment for obesity: the 5-HT2C receptor 

agonist lorcaserin.