Angeletti, L.M. Weiss, P. Wu and K. Kim. Albert Einstein Col.
of Med.
(826.1)
11:35
452.4
Structural insights into O-GlcNAc transferase.
S. Walker. Harvard Med. Sch.
12:00 Discussion and closing remarks.
453. LIPIDS IN NUTRIENT METABOLISM AND
METABOLIC DYSFUNCTION
Symposium
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9:55
Chair’s introduction.
10:00
453.1
TGR5, bile acids and the metabolic syndrome.
K. Schoonjans. Fed. Polytech Sch. of Lausanne (EPFL).
10:25
Fatty acids and their thioester derivatives
as potential endogenous ligands of LXR
a. G.V. Hines, A.
Kaliappan, S.D. Rider, Jr. and H.A. Hostetler. Boonshoft Sch.
of Med., Wright State Univ.
(1021.2)
10:40
453.2
Dietary fat composition modifies cell
sphingolipid biosynthesis to mediate the consequences of
obesity.
L.A. Cowart. Med. Univ. of South Carolina and Ralph
H. Johnson VA Med. Ctr.
11:05
Vitamin E and nonalcoholic fatty liver disease.
V. Thakur, L. Ulatowski, R. Parker, R. Zhang, X. Liu and
D. Manor. Case Western Reserve Univ., Cornell Univ. and
Cleveland Clin. Fndn.
(1017.11)
11:20
Modulating lipid fate controls lipotoxicity in
palmitate-treated hepatic cells.
A. Leamy, M. Shiota and J.
Young. Vanderbilt Univ. (1022.1)
11:35
453.3
Glycerolipid intermediates alter insulin
signaling.
R. Coleman, C. Zhang, D.E. Cooper, J. Iping, J.
Eaton, E. Klett and T.E. Harris. Univ. of North Carolina at
Chapel Hill and Univ. of Virginia.
12:00
Discussion and closing remarks.
454. MOLECULAR MOTOR PROTEINS—FORCE AND
WORK AS PRODUCTS
Symposium
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9:55
Chair’s introduction.
10:00
454.1
ATP utilization by DExD/H-box RNA helicases
– molecular motor proteins that couple ATPase activity with
RNA rearrangement.
E.M. De La Cruz. Yale Univ.
10:25 Can a b/delta fusion protein replace individual b and delta
subunits of ATP synthase in Escherichia coli?
C.S. Gajadeera
and J. Weber. Texas Tech Univ. and Texas Tech Univ. Hlth. Sci.
Ctr.
(1001.2)
450. MILDRED COHN AWARD IN BIOLOGICAL
CHEMISTRY
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9:00
Introductory remarks.
M. A. Lemmon.
9:05
450.1
Defending the genome: regulatory RNA in
humans and bacteria.
J. Doudna. HHMI, Univ. of California
Berkeley.
451. MECHANISMS OF GENOMIC STABILITY
Symposium
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atel
9:55
Chair’s introduction.
10:00
451.1
Genetic approaches to cancer.
S. Elledge, N.
Pavlova, T. Davoli and N. Solimini. Harvard Med. Sch.
10:25
Single molecular analysis of the encounter of
replication forks with DNA interstrand crosslinks.
J. Huang,
S. Liu, Y. Wang, A.K. Thazhathveetil, W. Wang and M.M.
Seidman. NIA, NIH, Baltimore, Univ. of California, Riverside
and Northwestern Univ.
(538.2)
10:40
451.2
Toxic metabolism and DNA repair and
hematopoesis.
K. Patel. MRC Lab. of Molec. Biol., Cambridge,
U.K.
11:05
Damaged DNA induced UV-damaged DNA-
binding protein dimerization and its roles in chromatinized DNA
repair.
J.I. Yeh, A.S. Levine and S. Du. Univ. of Pittsburgh Sch.
of Med.
(758.13)
11:20
DNA repair choice defines a common
pathway for recruitment of chromatin regulators.
G. Bennett,
M. Papamichos-Chronakis and C. Peterson. Univ. of
Massachusetts Med. Sch. and UMR218, Inst. Curie, Paris.
(760.2)
11:35
451.3
Functional divergence of Fanconi anemia
genes.
Y. Wang, J.W. Leung, Y. Jiang, M.G. Lowery, H.G. Do,
K.M. Vasquez, J. Chen, W. Wang and L. Li. MD Anderson
Cancer Ctr., Houston and Smithville and NIA, NIH, Baltimore.
12:00
Discussion and closing remarks.
452. REGULATION OF GENE EXPRESSION BY
O-GLCNAC
Symposium
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9:55
452.1
10:00
452.2
O-GlcNAc signaling regulates cancer
metabolism.
L. Hsieh-Wilson. Caltech.
10:25
Identification of osteoblast proteins O-GlcNAc
modified during osteogenesis.
A.K. Nagel, M. Schilling, M.
Berkaw and L.E. Ball. Med. Univ. of South Carolina. (827.1)
10:40
452.3
Hyper-O-GLcNAcation links cancer
metabolism to oncogenic signaling.
K. Vosseller and Z. Ma.
Drexel Univ. Col. of Med.
WEDNESDAY BIOCHEMISTRY
126
10:40
454.2
Kinesins – how the ATPase cycle modulates
function.
S.P. Gilbert. Rensselaer Polytech Inst.
11:05
Plasticity of the kinesin-microtubule interaction
is encoded by the motor domain beta-sheet.
J. Richard, E.
Kim, E. Wojcik and S. Kim. LSU Hlth. Sci. Ctr., New Orleans.
(999.1)
11:20
Regulation of assembly of bipolar myosin II
filaments.
A. Kandel, R. Frei and K. Prehoda. Univ. of Florida
and Univ. of Oregon.
(1004.3)
11:35
454.3
From force-sensing to power generation – how
force modulates the ATPase kinetics of myosin motors.
E.M.
Ostap, M.J. Greenberg, J.M. Laakso, Y.E. Goldman and H.
Shuman. Univ. of Pennsylvania.
12:00
Discussion and closing remarks.
455. MECHANISMS OF SIGNALING SPECIFICITY
IN CELL FATE: GROWTH, PROLIFERATION OR
DEATH?
Symposium
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9:55
Chair’s introduction.
10:00
455.1
mTOR complex 1, metabolism and cell growth
control.
J. Blenis, A. Csibi, S.G. Kim, X. Gu, J. Li, G. Buel, G.
Lee and Y.J. Jang. Harvard Med. Sch.
10:25
YAP mediates crosstalk between the Hippo
and PI(3)K–TOR pathways by suppressing PTEN via miR-29.
K.A. Tumaneng. UCSD. (1031.1)
10:40
455.2
ERK1/2-RSK regulation of cell fate in human
mammary ductal development.
D. Lannigan, D. Brenin, I.
Macara and L. Pasic. Vanderbilt Univ. and Univ. of Virginia.
11:05
AKAP7 regulates CaM kinase activation in
MCF-7 cells.
H.M. McFarland, K. Dodge-Kafka and J.M.
Schmitt. George Fox Univ., OR and Univ. of Connecticut Hlth.
Ctr.
(1031.15)
11:20
Tumor suppressor p53 status as a determinant
of estrogen receptor beta signaling in breast cancer.
G.M. Das,
U.K. Mukhopadhyay, S. Bansal, R. Medisetty, W.M. Swetzig
and N. Wickramasekera. Roswell Park Cancer Inst. (1031.21)
11:35
455.3
A common docking domain in progesterone
receptor-B links rapid signaling events to JAK/STAT-dependent
gene expression required for breast cancer cell proliferation.
C.A. Lange and C.R. Hagan. Univ. of Minnesota Masonic
Cancer Ctr.
12:00
Discussion and closing remarks.
456. REPRESSIVE CHROMATIN
Symposium
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yler
1:45
Chair’s introduction.
1:50
456.1
Higher-order chromatin folding and gene
regulation.
W. Bickmore. Inst. of Genet. and Molec. Med.,
Edinburgh, U.K.
2:15
Cohesin-dependent association of tRNA
genes with nuclear pore complexes in budding yeast.
M. Chen
and M.R. Gartenberg. UMDNJ-Robert Wood Johnson Med.
Sch.
(978.2)
2:30
456.2
Epigenetic mechanism: silent nucleosomal
structures and non-coding RNAs.
R.E. Kingston, K-J.
Armache, M.D. Simon, J. West, D. Grau, J. Garlick and C.
Davis. Massachusetts Gen. Hosp. and Harvard Med. Sch.
2:55
MeCP2’s role in chromatin structure and
stability.
C. Riedmann and Y. Fondufe-Mittendorf. Univ. of
Kentucky.
(770.1)
3:10
Characterization of lysine-specific demethylase
1 as a potential olfactory receptor regulator.
A.L. Savarino, S.
Kilinc and R. Lane. Wesleyan Univ. (980.7)
3:25
456.3
Mechanistic analysis of HP1 heterochromatin
assembly.
G. Narlikar, D. Canzio, M. Liao, N. Naber, E. Pate,
A. Larson, S. Wu, R. Cooke, P. Schuck and Y. Cheng. UCSF
and NIBIB, NIH.
3:50
Discussion and closing remarks.
457. FRONTIERS IN RNA BIOLOGY
Symposium
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1:45
Chair’s introduction.
1:50
457.2
CRISPR/Cas, the RNA-based adaptive
immune system of prokaryotes.
L.A. Marraffini. Rockefeller
Univ.
2:15
Expanding the transcriptomes at unstable
tandem repeat loci.
P.D. Ladd, A.N. Dubinsky, N.S. Lomas,
H.A. Ko and A.R. La Spada. UCSD. (778.1)
2:30
457.3
Integration of 3’UTR regulatory signals in the
worm germline.
S.P. Ryder, B.M. Farley and E. Kaymak. Univ.
of Massachusetts Med. Sch.
2:55
Structural insights into RNase T in RNA
maturation and DNA repair.
H.S. Yuan, Y-Y. Hsiao and W-C.
Chu. Inst. of Molec. Biol., Acad. Sinica, Taipei and Natl. Yang-
Ming Univ., Taiwan.
(988.1)
3:10
The amyotrophic lateral sclerosis and
frontotemporal dementia-associated C9ORF72 r(GGGGCC)n
hexanucleotide repeat forms extremely stable uni- and multi-
molecular RNA G-quadruplex structures.
K. Reddy, B. Zamiri,
S. Stanley, R. Macgregor and C. Pearson. The Hosp. for Sick
Children and Univ. of Toronto.
(990.1)
3:25
457.4
Evolution of RNA binding proteins and their
regulatory networks.
D. Herschlag. Stanford Univ.
3:50
Discussion and closing remarks.
458. REGULATORY THIOL MODIFICATIONS
Symposium
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1:45
Chair’s introduction.
1:50
458.1
Mechanism and function of DHHC
S-acyltransferases.
M.E. Linder, B. Jennings and J. Lai.
Cornell Univ.
2:15
Turnabout is fair play: mutual regulation of
palmitoylation and raft partitioning.
I. Levental and K. Simons.
Univ. of Texas Hlth. Sci. Ctr. at Houston and Max Planck Inst. of
Cell Biol. and Genet., Dresden.
(993.1)
BIOCHEMISTRY WEDNESDAY
127
W
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2:30
458.2
Redox control of chaperone function.
U.H.
Jakob, D. Reichmann, Y. Xu, M. Ilbert, C.M. Cremers and M.
Fitzgerald. Univ. of Michigan, Hebrew Univ. of Jerusalem and
Duke Univ.
2:55
Oxidation of the Hsp70 BiP protects cells
during ER stress.
C. Sevier, K. Pareja and J. Wang. Cornell
Univ.
(993.4)
3:10
Deubiquitinases as a signaling target of
oxidative stress.
T.T. Huang. NYU Sch. of Med. (782.6)
3:25
458.3
Protein tyrosine phosphatases: critical
regulators of signaling in cancer.
N.K. Tonks. Cold Spring
Harbor Lab., NY.
3:50
Discussion and closing remarks.
459. ASSEMBLY AND CONTROL OF DYNAMIC
PROTEIN COMPLEXES
Symposium
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1:45
Chair’s introduction.
1:50
459.1
Dynamic complexes of intrinsically disordered
proteins and their regulation by post-translational modifications.
J.D. Forman-Kay. Hosp. for Sick Children and Univ. of Toronto.
2:15
Structure-based drug design of inhibitors of
the CD23 and immunoglobulin E interaction.
M.O.Y. Pang, J.
McDonnell and A. Beavil. King’s Col. London. (1015.7)
2:30
459.2
Capturing transient transcriptional activator-
coactivator complexes with large and small molecules.
A.K.
Mapp. Univ. of Michigan.
2:55
Characterization of a novel interaction between
BLIP-II and Staphylococcus aureus PBP2a.
C.J. Adamski,
D-C. Chow, N. Brown and T. Palzkill. Baylor Col. of Med.
(1013.2)
3:10
Crosslinking mass spectrometry with novel aryl-
dialdehyde reagents reveal extended conformational dynamics
of RNA polymeraseII.
M.J. Trnka and A.L. Burlingame. UCSF.
(797.4)
3:25
459.3
Functional interactions of intrinsically
disordered proteins in signaling networks.
P.E. Wright. The
Scripps Res. Inst.
3:50
Discussion and closing remarks.
460. GENOMICS: SUCCESSES AND CHALLENGES
IN IDENTIFYING NOVEL TARGETS IN MINORITY
POPULATIONS
Symposium
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1:45
Chair’s introduction.
1:50
460.1
Ethnogenetic layering to link and predict
African American breast cancer patient outcomes with specific
African origins.
F.L.C. Jackson. Univ. of North Carolina at
Chapel Hill.
2:15
A molecular analysis and clinical follow up:
a strategy for hereditary cancer prevention.
B.L. Soares,
L.L. Santos, K.E. Lima, L.H. Mayrink, A.A.S. Valentin,
E.S. Oliveira, S. Lemos, D.O. Lopes, L.A. Barbosa and A.
Rodrigues. Fed. Univ. of São João Del Rei and Cancer Hosp.
of Divinopolis, Brazil. (608.1)
2:30
460.2
Use of GWAS to predict targets associated
with cancer in African Americans.
R. Kittles. Univ. of Illinois at
Chicago.
2:55
ABCD3 gene important in prostate cancer.
R.R. Reams, J. Jones-Triche, H. Wang, K.F.A. Soliman and
C.C. Yates. Col. of Pharm., Florida A&M Univ. and Tuskegee
Univ.
(608.3)
3:10
Obesity polymorphisms identified in genome-
wide association studies interact with n-3 polyunsaturated
fatty acid intake and modify genetic associations with adiposity
phenotypes in Yup’ik people.
D.J. Lemas, Y.C. Klimentidis,
H.H. Wiener, D.M. O’Brien, S. Hopkins, D.B. Allison, J.R.
Fernandez, H.K. Tiwari and B.B. Boyer. Univ. of Alaska
Fairbanks and Univ. of Alabama at Birmingham.
(608.2)
3:25
460.3
Integrative genomic strategies for biomarker
discovery in breast cancer in minority populations.
C. Hicks.
Univ. of Mississippi Med. Ctr.
3:50
Discussion and closing remarks.
Join Us Next Year!
Experimental Biology 2014
April 26 – 30 • San Deigo, CA
American Association of Anatomists (AAA)
The American Physiological Society (APS)
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society for Investigative Pathology (ASIP)
American Society for Nutrition (ASN)
American Society for Pharmacology and Experimental Therapeutics (ASPET)
For further information:
www.experimentalbiology.org
WEDNESDAY BIOCHEMISTRY
128
Nutrition
463. ASN SATELLITE SESSION: FIRST GLOBAL
SUMMIT ON THE HEALTH EFFECTS OF YOGURT
Special Session
(Supported by an educational grant from the Danone
Institute International)
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hamir
8:00
Welcome and introductions.
S. M. Donovan, R. Shamir.
Univ. of Illinois, Urbana, Sackler Fac. of Med., Tel Aviv
Univ.
8:15
Consumption of dairy products and public health.
A.
Prentice. London Sch. of Hyg. & Trop. Med.
8:45
Dairy and yogurt consumption.
D. McCarron. Univ. of
California, Davis.
9:15
Nutrient density: Principles and evaluation tools and
yogurt case illustration.
A. Drewnowski. Univ. of
Washington.
10:15 Break.
10:45
Concurrent workshops (some listed in separate rooms).
11:45
Lunch (boxed lunch distribution in the room).
12:20
Report from concurrent workshops.
1:00
Moderated group discussions: How can yogurt improve
one’s diet and health?
A. Tremblay, F. Kok. Laval
Univ., Canada , Wageningen Univ., Netherlands.
1:00
Yogurt and weight management: A new potential
paradigm.
P. Jacques. Tufts Univ.
1:30
Yogurt and metabolic diseases: What do the data show?
A. Astrup. Univ. of Copenhagen.
2:00
Diet and lifestyle behaviors of yogurt consumers.
D. Grotto. Elmhurst, IL.
2:30
The science behind current dairy dietary guidelines.
C. Weaver. Purdue Univ.
3:00
Policy needs.
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