1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

M.A. Knepper. NHLBI, NIH. (1111.3)

9:15 ER

a66 contributes to early diabetic renal disease in 

mice. 

D.L. Irsik, R.W. Fallet, E. Adun, E. Chavez, 

H.L. Brooks, P.K. Carmines and P.H. Lane. Univ. 

of Nebraska Med. Ctr., Univ. of Arizona and Univ. of 

Oklahoma Hlth. Sci. Ctr. 

(702.12)

9:30 

Increased UT-A1 ubiquitination is partially due to 

decreased deubiquitination activity in streptozotocin-

induced diabetic rat kidney inner medulla. 

H. Su, T.O. 

Ilori, J.D. Klein, J.M. Sands and G. Chen. Emory 

Univ. 

(1111.4)

9:45  RNA-Seq analysis of glycosylation related gene 

expression in streptozotocin-induced diabetic rat 

kidney inner medulla. 

G. Chen, X. Li, H. Su, T.O. Ilori, 

J.D. Klein and R.P. Hughey. Emory Univ. and Univ. of 

Pittsburgh Sch. of Med. 

(1111.16)

TUESDAY PHYSIOLOGY

118

420.  EPIGENETICS AND EXERCISE

Featured Topic

(Sponsored by: APS Environmental and Exercise 

Physiology Section)

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Metabolic Diseases

10:30  Histone modifications and exercise adaptations. 

M. 

Hargreaves. Univ. of Melbourne.

11:00  DNA methylation and exercise. 

J. Zierath. Karolinska 

Inst.

11:30  Endurance training changes the DNA methylation 

pattern in human skeletal muscle. 

M.E. Lindholm, F. 

Marabita, D. Gomez-Cabrero, H. Fischer, J. Tegnér 

and C.J. Sundberg. Karolinska Inst., Stockholm and 

Huddinge. 

(1134.1)

11:45 HDZCs are O-GlcNAc modified and OGT 

O-GlcNAcylation is decreased with acute exercise. 

H.M. Medford and S.A. Marsh. Washington State 

Univ. 

(1134.2)

12:00 

Exercise during pregnancy attenuates prenatal high-fat 

diet-induced hypermethylation of the Pgc-1

a gene 

and protects against age-induced glucose intolerance 

in the offspring. 

R.C. Laker, T. Lillard, M. Okutsu, J. 

Connelly and Z. Yan. Univ. of Virginia. (1134.3)

12:15  Maternal exercise during pregnancy improves glucose 

metabolism of offspring. 

K.I. Stanford, M-Y. Lee, K.M. 

Getchell, M.F. Hirshman and L.J. Goodyear. Joslin 

Diabetes Ctr. 

(1134.4)

421.  INFLAMMATION AS AN ORCHESTRATOR IN 

HEART FAILURE

Featured Topic

(Sponsored by: APS Cardiovascular Section)

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Inflammation and Immune Responses

Translational Physiology

10:30  Chair introduction: inflammation as an orchestrator in 

heart failure. 

R. M. Altara. Univ. of Maastricht.

10:40  Regulation of the inflammatory response in cardiac 

repair. 

N. G. Frangogiannis. Albert Einstein Col. of Med.

11:05  Nicotine reduced post-infarct inflammation and improved 

cardiac output during exercise in conscious mice. 

H.L. Lujan, 

R. Wang, A.J. Blumberg and S.E. DiCarlo. Wayne State Univ. 

Sch. of Med. 

(1128.17)

11:20 Osteonectin protects against adverse cardiac 

inflammation during viral myocarditis. 

A. Papageorgiou, 

M. Rienks, D. Vanhoutte, W. Verhesen, P. Carai, T. 

Vandendriessche, M. Chuah and S. Heymans. Maastricht 

Univ., Netherlands, Univ. Leuven, Belgium and Cincinnati 

Children’s Hosp. Med. Ctr. 

(1128.8)

11:35 Circulating 

Porphyromonas gingivalis lipopolysaccharide 

induces left ventricular dysfunction through MMP-

9 regulation of inflammation. 

K.Y. DeLeon, L.E. de 

Castro Bras, J. Zhang and M.L. Lindsey. Univ. of 

Texas Hlth. Sci. Ctr. at San Antonio. 

(1128.14)

11:50  The inflammatory mediator SH2B3 increases risk of 

heart failure. 

M.J. Flister, C. Moreno, M.J. Hoffman, 

S.Z. Prisco, J. Lazar, J.L. Hall and H.J. Jacob. Med. 

Col. of Wisconsin and Univ. of Minnesota, Minneapolis. 

(1128.16)

12:05  Cardiac remodeling and the immune system: insides 

from basic and clinical science. 

S. Frantz. Univ. of 

Wurzburg.

422.  INTEGRATIVE CARDIOVASCULAR AND 

RESPIRATORY PHYSIOLOGY OF NON-MODEL 

ORGANISMS

Featured Topic

(Sponsored by: APS Comparative and Evolutionary 

Physiology Section)

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me

Hypoxia and Oxidative Stress

10:30  Chronic hypoxia (10% O

2

) alters cardiovascular 

regulation and gene expression in snapping turtle 

embryos (Chelydra serpentina). 

J. Eme, T. Rhen, 

K.B. Tate, K. Gruchalla, Z.F. Kohl, C.E. Slay and 

D.A. Crossley II. Univ. of North Texas, Univ. of North 

Dakota and Univ. of California, Irvine. 

(714.15)

10:45  Developmental phenotypic plasticity of reptiles and 

birds. 

D. Crossley. Univ. of North Texas.

11:15  Video microscopy detection of oyster spat heart 

rate: acclimation temperature alters HR response 

to acute temperature change. 

N.J. Domnik, E.T. 

Polymeropoulos, N.G. Elliott, P.B. Frappell and J.T. 

Fisher. Queen’s Univ., Canada, Univ. of Tasmania, 

Australia and Commonwealth Sci. and Indust. Res. 

Org., Hobart, Australia. 

(714.9)

11:30  Heart rate and metabolic rate of bar-headed geese 

flying in hypoxia. 

J.U. Meir, W. Jardine, J. York, B. 

Chua and W.K. Milsom. Harvard Med. Sch. and Univ. 

of British Columbia. 

(1149.16)

11:45 

Functional and morphological changes in the trout heart 

during thermal acclimation. 

J.M. Klaiman, W.G. Pyle 

and T.E. Gillis. Univ. of Guelph, Canada. (714.10)

12:00  Cardiac remodeling from a fish perspective. 

H. Shiels. 

Univ. of Manchester.

LAST DAY TO  

VISIT EXHIBITS

Tuesday, April 23

9:00 AM – 4:00 PM

PHYSIOLOGY TUESDAY

119

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423.  ION TRANSPORT IN CELL DIFFERENTIATION, 

MIGRATION, POLARIZATION AND ADHESION

Featured Topic

(Sponsored by: APS Cell and Molecular Physiology 

Section)

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Transporters and Ion Channels

10:30 

b-Adrenergic receptor agonists known to stimulate 

b-arrestin-dependent signaling inhibit CFTR activity, 

cell migration and airway epithelial restitution. 

E.R. 

Peitzman and S.M. O’Grady. Univ. of Minnesota, St. 

Paul. 

(1145.4)

10:45  On the potential role of potassium channel KCNK5 

in human T cell activation. 

S.S. Kirkegaard, A.J. 

Hansen, S. Gammeltoft and E.K. Hoffmann. Univ. 

of Copenhagen, Glostrup Hosp. and Novo Nordic, 

Måløv, Denmark. 

(913.29)

11:00  Adenosine inhibits human T lymphocyte migration 

via inhibition of KCa3.1 channels. 

A.A. Chimote, 

V. Kucher, N. Boiko, P. Hajdu, Z. Kuras, Y-H. Yun, 

O. Szilagyi and L. Conforti. Univ. of Cincinnati and 

North Carolina A&T State Univ. 

(1145.6)

11:15  Regulation of cell motility by Na

+

/H

+

 exchanger NHE1: 

implications for cancer development. 

S. F. Pedersen. 

Univ. of Copenhagen.

11:45  ERM proteins colocalize with the Na

+

/H

+

 exchanger 

NHE1 in MCF-7 breast cancer cell invadopodia and 

affect invadopodia number. 

G.A.B. Roest and S.F. 

Pedersen. Univ. of Copenhagen. (1145.2)

12:00  TRPV4-mediated Ca

2+

 influx promotes airway smooth 

muscle cell proliferation via NFATc3. 

L. Zhao, M.N. 

Sullivan, A.L. Gonzales and S. Earley. Colorado 

State Univ. 

(913.50)

12:15  Chloride channel inhibition reduces tail regeneration in 

the developing vertebrate Ambystoma mexicanum. 

B.M. Franklin, R. Voss and J. Osborn. Univ. of 

Kentucky. 

(1145.5)

424.  IS THERE A PHYSIOLOGICAL ROLE FOR 

C-PEPTIDE?

Symposium

(Sponsored by: APS Endocrinology and Metabolism 

Section)

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osten

Metabolic Diseases

10:30  The relevance of C-peptide in diabetes and its 

complications: introduction. 

J. Wahren. Karolinska 

Inst.

11:00  Effects of C-peptide in the diabetic kidney. 

C. Maric-

Bilkan. Univ. of Mississippi Med. Ctr.

11:30 

Anti inflammatory effects of C-peptide. 

P. Luppi. Univ. of 

Pittsburgh Sch. of Med.

12:00  Searching for the C-peptide receptor. 

G. Yosten. Saint 

Louis Univ. Sch. of Med.

425.  JULIUS H. COMROE, JR. DISTINGUISHED 

LECTURESHIP OF THE APS RESPIRATION 

SECTION

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Title:  The Serpentine Path to a Novel Mechanism-Based 

Inhibitor of Acute Inflammatory Lung Injury

Speaker: 

A. Fisher. Univ. of Pennsylvania Sch. of Med.

426.  NEUROTRANSMISSION AND CA

2+

-

SENSITIZATION IN GASTROINTESTINAL 

SMOOTH MUSCLES

Featured Topic

(Sponsored by: APS Gastrointestinal and Liver 

Physiology Section)

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Transporters and Ion Channels

10:30  Cholinergic neurotransmission and bath applied 

agonists activate different Ca

2+

 sensitization pathways 

in gastric smooth muscles. 

B. A. Perrino. Univ. of 

Nevada Sch. of Med.

11:00  Calcium sensitization mechanisms of colonic smooth 

muscle during inflammation: a novel role for MAPK-

dependent regulation of myosin phosphatase. 

J. 

MacDonald. Univ. of Calgary.

11:30  NANC neuron mediated relaxation of murine gastric 

fundus smooth muscle: phosphorylation of MYPT1 on 

T696 (ROK site) and S695 (PKG site) are mutually 

exclusive. 

G. Pfitzer, M.S. Hunger, S. Puetz, D. 

Metzler, L.T. Lubomirov and A.V. Somlyo. Univ. of 

Cologne, Germany and Univ. of Virginia. 

(1164.1)

11:45 

Inhibition of RhoA/Rho kinase pathway and contraction 

by endogenous and exogenous hydrogen sulfide 

in gastrointestinal smooth muscle. 

A.D. Nalli, S. 

Rajagopal, S. Mahavadi, J.R. Grider and K.S. 

Murthy. Virginia Commonwealth Univ. (1164.2)

12:00 

Pharmacologically-induced alterations in gastrointestinal 

motility affects regional colonic microbial assemblage. 

K. Touw, Y. Wang, E. Huang, V. Leone and E. Chang. 

Univ. of Chicago. 

(1164.3)

427.  OBESITY AND INFLAMMATION: 

CONTRIBUTIONS TO VASCULAR AND RENAL 

DISEASE

Featured Topic

(Sponsored by: APS Water and Electrolyte Homeostasis 

Section)

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10:30  Obesity fans the flames of inflammatory diseases. 

P. 

Libby. Brigham and Women’s Hosp.

TUESDAY PHYSIOLOGY

120

11:00 Weight-loss surgery rapidly alleviates platelet 

hyperactivity in morbid obesity. 

Y. Dobrydneva, M. 

Periasamy, M. Butcher, E. Galkina, N. Kuhn, D. 

Lieb, M. Fontana, S. Wohlgemuth and J. Nadler. 

Eastern Virginia Med. Sch. and Sentara Med. Gp., 

Norfolk. 

(1114.1)

11:15  Role of the angiotensin AT

2

 receptor in obesity-linked 

inflammation and renal injury: effect of gender. 

I. 

Dhande, M.A. Khan, S. Nag and T. Hussain. Univ. of 

Houston. 

(1114.2)

11:30 Etanercept improves glucose intolerance and 

dyslipidemia in insulin-resistant rats. 

A. Lee, R. 

Rodriguez, R. Ortiz and M. Ryan. Univ. of California 

Merced and Univ. of Mississippi Med. Ctr. 

(1114.3)

11:45 

Mutation of Sh2b3 attenuates Dahl SS hypertension via 

inflammatory signaling. 

N. Rudemiller, H. Lund, C. 

Guo, A. Geurts, H. Jacob and D.L. Mattson. Med. 

Col. of Wisconsin. 

(1114.4)

12:00 

Acute kidney injury following orthopedic trauma in obese 

Zucker rats. 

P. Mittwede, L. Xiang, J. Clemmer, S. 

Lu, A. Gowdey and R. Hester. Sch. of Med., Univ. of 

Mississippi Med. Ctr. 

(1114.6)

428.  THE ROLE OF ER STRESS IN 

CARDIOVASCULAR DISEASE

Featured Topic

(Sponsored by: APS Neural Control and Autonomic 

Regulation Section)

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Blood Pressure Regulation

Central Control of Homeostasis

10:30 

ER stress in the brain and hypertension. 

R. L. Davisson. 

Cornell Univ.

11:00  ER stress, inflammation and metabolic syndrome. 

D. 

Cai. Albert Einstein Col. of Med.

11:30  Relief of endoplasmic reticulum stress in the brain 

subfornical organ selectively prevents high fat diet-

induced hepatic dysfunction but not the development 

of adiposity or hypertension. 

C.N. Young,  J.A. 

Horwath, S.D. Butler, A.L. Mark and R.L. Davisson. 

Cornell Univ., Univ. of Iowa and Weill Cornell Med. 

Col. 

(929.4)

11:45  Activation of the unfolded protein response in vascular 

endothelial cells of non-diabetic obese middle-aged 

and older adults. 

R.E. Kaplon, D.R. Seals and C.L. 

Gentile. Univ. of Colorado Boulder and Colorado 

State Univ. 

(929.2)

12:00  Cardiomyocyte specific overexpression of C3orf58 

activates ER stress leading to impaired cardiac 

function. 

Z. Zhang, M. Mirotsou, A. Payne, H. Mu, 

L. Zhang, E.A. Finch, R.E. Pratt, P. Rosenberg and 

V.J. Dzau. Duke Univ. Med. Ctr. (929.7)

12:15  ACE2 inhibits endoplasmic reticulum stress and 

autophagy associated to neurogenic hypertension. 

H. Xia, T. Johnson, I. Mungrue and E. Lazartigues. 

LSU Hlth. Sci. Ctr., New Orleans. 

(929.1)

429.  TISSUE ENGINEERING OF EPITHELIAL 

ORGANS: APPLICATIONS TO PHYSIOLOGY 

AND DISEASE

Symposium

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10:30 

Developmental approaches to kidney tissue engineering. 

S. Nigam. UCSD.

11:00 

Microscale hepatic tissue engineering. 

S. Bhatia. MIT.

11:30  A human 3D lung tissue model using acellular lung 

scaffold to study disease and formation of fibrosis. 

J. 

Cortiella. Univ. of Texas Med. Branch.

12:00  Tissue-engineering the intestinal tract: the importance 

of the stem cell niche. 

T. Grikscheit. Univ. of Southern 

California.

430.  HISTORY OF PHYSIOLOGY GROUP LECTURE

(Sponsored by: APS History of Physiology Group)

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 D

Title:  Resolving an 80-Year-Old Controversy on the 

Formation of Urine That Began the Modern Era of 

Renal Physiology

Speaker:

  R. L. Jamison. Stanford Univ.

431.  ROBERT M. BERNE DISTINGUISHED 

LECTURESHIP OF THE APS CARDIOVASCULAR 

SECTION

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Title:  A Long and Winding Road: The Story of Nitric 

Oxide in the Heart

Speaker: 

D. J. Lefer. Emory Univ. Sch. of Med.

432.  AUGUST KROGH DISTINGUISHED 

LECTURESHIP OF THE APS COMPARATIVE 

AND EVOLUTIONARY PHYSIOLOGY SECTION

(Sponsored by: Novo Nordisk Foundation)

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Title:  From Tusko to Titin: Giant Insights from 

Comparative Physiology 

Speaker:

  S. Lindstedt. Northern Arizona Univ.

PHYSIOLOGY TUESDAY

121

T

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433.  BRAIN RENIN-ANGIOTENSIN SIGNALING IN 

METABOLIC DISEASES

Featured Topic

(Sponsored by: APS Neural Control and Autonomic 

Regulation Section)

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pm

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 h. x

ia

Metabolic Diseases

3:15 

Metabolic rate regulation: opposing roles of brain and 

peripheral renin-angiotensin systems. 

J. L. Grobe. 

Univ. of Iowa.

3:45 

Brain angiotensin-converting enzyme 2 in the regulation 

of metabolism. 

H. Xia. LSU Hlth. Sci. Ctr., New 

Orleans.

4:15 

Mice lacking the gene for Toll like receptor-4 had an 

attenuated blood pressure response to angiotensin 

II infusion. 

R.B. Dange, H. Peng, Y. Feng and J. 

Francis. Sch. of Vet. Med., LSU and Sch. of Med., 

Tulane Univ. 

(696.4)

4:30 

Selective knockout of novel intracellular renin isoform 

results in reduced adiposity. 

M.D. Folchert, N.K. 

Littlejohn, X. Liu, J.L. Grobe and C.D. Sigmund. 

Univ. of Iowa. 

(696.2)

4:45 

Deletion of p22

phox

-dependent reactive oxygen species 

in the paraventricular nucleus protects against diet-

induced obesity by increasing thermogenesis and 

lipolysis.