AN-1401-071
APPLICATION OF DESFLURANE IN ANAESTHESIOLOGY
Moshchev D.A., Lubnin A.Yu.
Burdenko Research Institute of Neurosurgery of the Russian Academy of Medical Sciences, Moscow, Russia
correspondence to:
Moshchev Dmitry Aleksandrovich
e-mail:
DMoshev@nsi.ru
Abstract:
Desflurane (Des) – is a modern inhalation anaesthetic available in Russia since August, 2013. Des
is a halogenated ether; its chemical structure is 2-difluoromethoxy-1-1-1-2-tetrafluoroethane (
С
3
Н
2F6O).
Special thermocompensated evaporators are used for Des dosing. Low solubility in blood and tissues of an
organism causes fast absorption and elimination of Des. Blood/gas distribution ratio of Des is 0.42. Des
distinctive properties are high saturated vapor pressure, super short duration of action and average power.
Furthermore it is characterized by the minimal metabolism and lack of interaction with soda lime. Des is used
for general anesthesia in a cardiac surgery, neurosurgery, out-patient surgery, pediatric practice and other
areas of surgery. Des has more positive qualities and fewer limitations, than other inhalation anaesthetics
(halothane, isoflurane, sevoflurane). High cost of the anaesthetic is compensated by quality and controllability
of anaesthesia and reduction of stay time in recovery unit. Fast elimination of the anaesthetic from a body
allows reducing a frequency of complications connected with violation of upper airway and hypoxemia,
promotes early discontinuation of artificial ventilation, reducing somnolence, earlier restoring a muscular tone
in the postoperative period.
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