OUTCOMES OF SURGICAL CORRECTION OF CONGENITAL TIBIA PSEUDARTHROSIS DEPENDING
ON THE ACTIVATION OF HHV-6/HHV-7 VIRAL INFECTION IN A CHILD WITH NEUROFIBROMATOSIS
TYPE-1
Vilks A.
1
, Ozols Dz.
1
, Boka V.
1
, Murovska M.
2
, Mamaja B.
1,3
1Riga Eastern Clinical University Hospital Gailezers, LV-1039, Riga, Latvia; 2
Riga StradiņšUniversity,A.
Kirchenstein Institute of Microbiology and Virology, LV-1067, Riga, Latvia; 3 Riga
StradiņšUniversity,Department of Anaesthesiology and Reanimatology, L
V-1039, Riga, Latvia
correspondence to:
Biruta Mamaja
e-mail:
Biruta.Mamaja@aslimnica.lv
Abstract:
Neurofibromatosis type-1 (NF-1) – is a common genetic disease effecting the skin, subcutaneous
tissue peripheral nerves and bones (tibia pseudarthrosis). Immunomodulatory viruses HHV-6 and HHV-7 are
classifying as a genus of roseoloviruses of subfamily
β
-herpesviruses. Reactivation of HHV-6 and HHV-7
inhibits immune system and indirectly promote to other infectious agents. The article deals with a unique
case repot of two repeated transplantations of fibula due to congenital tibia pseudarthrosis caused by NF-1.
Results of the transplantations, related to active and latent HHV- 6 and HHV-7 infection in a 6 years old child
are discussed in the paper.
Key words:
neurofibromatosis, HHV-6, HHV-7, activeinfection, latentinfection
AN-1401-063
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