Early Childhood Caries: Prevalence, Risk Factors, and Prevention

J Public Health (2000) 91(6):411–7. 
59. Olmez S, Uzamis M, Erdem G. Association between early childhood caries 
and clinical, microbiological, oral hygiene and dietary variables in rural 
Turkish children. Turk J Pediatr (2003) 45(3):231–6. 
60. Gaur S, Nayak R. Underweight in low socioeconomic status preschool chil-
dren with severe early childhood caries. J Indian Soc Pedod Prev Dent (2011) 
29(4):305–9. doi:10.4103/0970-4388.86375 
61. Aida J, Ando Y, Aoyama H, Tango T, Morita M. An ecological study on the 
association of public dental health activities and sociodemographic charac-
teristics with caries prevalence in Japanese 3-year-old children. Caries Res 
(2006) 40(6):466–72. doi:10.1159/000095644 
62. Jiang S, Gao X, Jin L, Lo EC. Salivary microbiome diversity in caries-free 
and caries-affected children. Int J Mol Sci (2016) 17(12):E1978. doi:10.3390/
ijms17121978 
63. Silva PV, Troiano JA, Nakamune AC, Pessan JP, Antoniali C. Increased activity 
of the antioxidants systems modulate the oxidative stress in saliva of toddlers 
with early childhood caries. Arch Oral Biol (2016) 70:62–6. doi:10.1016/j.
archoralbio.2016.06.003 

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Anil and Anand
Early Childhood Caries
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July 2017 | Volume 5 | Article 157
64. Pitiphat W, Luangchaichaweng S, Pungchanchaikul P, Angwaravong O, 
Chansamak N. Factors associated with molar incisor hypomineralization 
in Thai children. Eur J Oral Sci (2014) 122(4):265–70. doi:10.1111/eos. 
12136 
65. Prokocimer T, Amir E, Blumer S, Peretz B. Birth-weight, pregnancy term, 
pre-natal and natal complications related to child’s dental anomalies. J Clin 
Pediatr Dent (2015) 39(4):371–6. doi:10.17796/1053-4628-39.4.371 
66. Lai PY, Seow WK, Tudehope DI, Rogers Y. Enamel hypoplasia and dental 
caries in very-low birthweight children: a case-controlled, longitudinal study. 
Pediatr Dent (1997) 19(1):42–9. 
67. Dabawala S, Suprabha BS, Shenoy R, Rao A, Shah N. Parenting style and oral 
health practices in early childhood caries: a case-control study. Int J Paediatr 
Dent (2017) 27(2):135–44. doi:10.1111/ipd.12235 
68. Leroy R, Hoppenbrouwers K, Jara A, Declerck D. Parental smoking behavior 
and caries experience in preschool children. Community Dent Oral Epidemiol 
(2008) 36(3):249–57. doi:10.1111/j.1600-0528.2007.00393.x 
69. Drury TF, Horowitz AM, Ismail AI, Maertens MP, Rozier RG, Selwitz RH. 
Diagnosing and reporting early childhood caries for research purposes. 
A report of a workshop sponsored by the National Institute of Dental and 
Craniofacial Research, the Health Resources and Services Administration, 
and the Health Care Financing Administration. J Public Health Dent (1999) 
59(3):192–7. 
70. Barber LR, Wilkins EM. Evidence-based prevention, management, and 
monitoring of dental caries. J Dent Hyg (2002) 76(4):270–5. 
71. Von Burg MM, Sanders BJ, Weddell JA. Baby bottle tooth decay: a concern for 
all mothers. Pediatr Nurs (1995) 21(6):515–9. 
72. Li MY, Zhi QH, Zhou Y, Qiu RM, Lin HC. Impact of early childhood caries 
on oral health-related quality of life of preschool children. Eur J Paediatr Dent 
(2015) 16(1):65–72. 
73. Wyne A. Prevalence and risk factors of nursing caries in Adelaide, South 
Australia. Pediatr Dent (1999) 9:31–6. 
74. Veerkamp JS, Weerheijm KL. Nursing-bottle caries: the importance of a 
development perspective. ASDC J Dent Child (1995) 62(6):381–6. 
75. Berkowitz RJ, Koo H, McDermott MP, Whelehan MT, Ragusa P, Kopycka-
Kedzierawski DT, et al. Adjunctive chemotherapeutic suppression of mutans 
streptococci in the setting of severe early childhood caries: an exploratory 
study. J Public Health Dent (2009) 69(3):163–7. doi:10.1111/j.1752-7325.2009. 
00118.x 
76. Duangthip D, Jiang M, Chu CH, Lo EC. Restorative approaches to treat dentin 
caries in preschool children: systematic review. Eur J Paediatr Dent (2016) 
17(2):113–21. 
77. Amin MS, Harrison RL, Benton TS, Roberts M, Weinstein P. Effect of 
povidone-iodine on Streptococcus mutans in children with extensive dental 
caries. Pediatr Dent (2004) 26(1):5–10. 
78. Jayaprakash R, Sharma A, Moses J. Comparative evaluation of the efficacy 
of different concentrations of chlorhexidine mouth rinses in reducing the 
mutans streptococci in saliva: an in vivo study. J Indian Soc Pedod Prev Dent 
(2010) 28(3):162–6. doi:10.4103/0970-4388.73792 
79. Frentzen M, Ploenes K, Braun A. Clinical and microbiological effects of
local chlorhexidine applications. Int Dent J (2002) 52(5):325–9. doi:10.1002/j. 
1875-595X.2002.tb00879.x 
80. Twetman S, Axelsson S, Dahlgren H, Holm AK, Kallestal C, Lagerlof F, et al. 
Caries-preventive effect of fluoride toothpaste: a systematic review. Acta 
Odontol Scand (2003) 61(6):347–55. doi:10.1080/00016350310007590 
81. Marinho VC, Worthington HV, Walsh T, Clarkson JE. Fluoride varnishes 
for preventing dental caries in children and adolescents. Cochrane
Database Syst Rev (2013) 11(7):Cd002279. doi:10.1002/14651858.CD002279.
pub2 
82. Marinho VC, Chong LY, Worthington HV, Walsh T. Fluoride mouth-
rinses for preventing dental caries in children and adolescents. Cochrane
Database Syst Rev (2016) 11(7):Cd002284. doi:10.1002/14651858.CD002284. 
pub2 
83. Pukallus ML, Plonka KA, Holcombe TF, Barnett AG, Walsh LJ, 
Seow WK. A randomized controlled trial of a 10 percent CPP-ACP cream 
to reduce mutans streptococci colonization. Pediatr Dent (2013) 35(7): 
550–5. 
84. Zhou C, Zhang D, Bai Y, Li S. Casein phosphopeptide-amorphous calcium 
phosphate remineralization of primary teeth early enamel lesions. J Dent 
(2014) 42(1):21–9. doi:10.1016/j.jdent.2013.11.005 
85. Jackson JT, Quinonez RB, Kerns AK, Chuang A, Eidson RS, Boggess KA, 
et al. Implementing a prenatal oral health program through interprofessional 
collaboration. J Dent Educ (2015) 79(3):241–8. 
86. Record S, Montgomery DF, Milano M. Fluoride supplementation and 
caries prevention. J Pediatr Health Care (2000) 14(5):247–9. doi:10.1067/
mph.2000.108756 
87. Uribe S. Prevention and management of dental decay in the preschool child. 
Aust Dent J (2006) 51(3):272–5. doi:10.1111/j.1834-7819.2006.tb00442.x 
88. Lee GH, McGrath C, Yiu CK. Evaluating the impact of caries prevention 
and management by caries risk assessment guidelines on clinical practice in 
a dental teaching hospital. BMC Oral Health (2016) 16(1):58. doi:10.1186/
s12903-016-0217-9 
89. Kim Seow W. Environmental, maternal, and child factors which contribute 
to early childhood caries: a unifying conceptual model. Int J Paediatr Dent 
(2012) 22(3):157–68. doi:10.1111/j.1365-263X.2011.01186.x 
90. Hedayati-Hajikand T, Lundberg U, Eldh C, Twetman S. Effect of probiotic 
chewing tablets on early childhood caries – a randomized controlled trial. 
BMC Oral Health (2015) 15(1):112. doi:10.1186/s12903-015-0096-5 
91. Jorgensen MR, Castiblanco G, Twetman S, Keller MK. Prevention of caries 
with probiotic bacteria during early childhood. Promising but inconsistent 
findings. Am J Dent (2016) 29(3):127–31.