44
| New Scientist | 14 September 2019
“ I have this
shadow that
nobody knows
about, that I’m so
ashamed of”
believed people became hooked on the
pleasurable, rewarding dopamine rush. Others
observed that for addicts like Ian and Louise
(see case studies on pages 43 and 45), there is
little pleasure left. Instead, it could be that
regularly hitting
up the dopamine system left
lasting changes in brain function, so the drug
became necessary for a user to feel normal.
It wasn’t until the 1990s, with the rise
of molecular imaging, known as PET scans,
that we could see the impact of drugs on the
human brain
in real time and watch what
happens to the dopamine system.
One major finding was that the prefrontal
cortex, where decisions are made, is far
quieter in the brains of people who are
addicted than in those who aren’t. This
suggests that their brain function had
changed as
a result of drug use, says Everitt,
leaving them less able to control their own
behaviour. Whether an addict uses drugs to
attain pleasure or avoid misery, continued use
will ultimately depend
on the extent to which
they are able to control their impulses.
This helps to explain how habits come to
form a big part of addiction. For instance,
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