Poster presentation
161
GERFINE - NEW ALKALOID FROM Haplophyllum griffithianum
D.R.Kodirova, Kh.A.Rasulova
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences
of the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
e-mail: dilobar555@mail.ru
The pharmacological studies of alkaloids and their derivatives isolated from plants of
Haplophyllum
genus
(fam. Rutaceae
), which are unique source of various alkaloids,
showed that they are low toxic and have wide spectrum of pharmacological action.
Most of them possess by inhibitory action on CNS, sedative, sleeping, anticonvulsant,
estrogen and other effects.
As a result of research of total alkaloids with yields 0,4% and 0,58% respectively,
which isolated from the aerial part and roots of
H. griffithianum
collected in
Sanchardaksoy, Nilu village, (Surkhandarya province). The known alkaloids
skimmianine, dictamnine, dubinine, dubamine, a gerfitin with m.p. 91-93
C, gerfitinin
with m.p. 91-93
C and a new bases – gerfin were isolated for the first time from the
aerial part, and skimmianine, dictamnine, dubinine and sterols with m.p. 76-78
C, and
60
C – from the roots. The structure of gerfine (I) was proved by spectral data.
Gerfine (
1
): ESI-MS
m/z
227 (M
+
), C
14
H
13
NO
2,
(CHCl
3
:MEOH, 9:1) (R
f
0.70).
1
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