Organizing co mmittee

POLYMERIC PREPARATION FOR THE TREATMENT AND 
PREVENTION OF GYNECOLOGICAL DISEASES IN FARM 
ANIMALS 
 
T.M. Babaev, M.M. Karimov, Z.X. Urinova 
 
Samarkand University of Veterinary Medicine, Animal Husbandry and 
Biotechnology. Uzbekistan, Samarkand. 702138. 
e-mail: Samvmi.uz/uz 
This report is devoted to the development of polymer compositions of anti-
inflammatory drugs based on polycomplexes, the development of formulations and 
technology for the production of a polymer suspension, as well as a foaming 
composition for the treatment and prevention of obstetric and gynecological diseases in 
agricultural animals. Dosage forms of polymer compositions were prepared in the form 
of a suspension (CARBOKAZ), i.e., polymeric complex mixtures of preparations with a 
wide spectrum of antibacterial action based on azidine or diamidine and foaming 
tablets. The main criteria for assessing the quality of such tablets are strength, low 
abrasion, disintegration and abundant foaming, as well as the indifference of excipients. 
For abundant foaming, various water-soluble low-toxic polymers were tested, such as 
polyacrylamide and sodium salt of carboxymethyl cellulose (Na-CMC) with molecular 
weights of 7000 and 54000. As medicinal substances, a composition (diamidinetonium-
furatsilin) was used, which is used in UzNIVI for the treatment of gynecological 
diseases of a large cattle, and as gas-forming disintegrants, a mixture of sodium 
bicarbonate with citric acid. As a filler, in a model tablet, glucose was used, a humectant 
10% aqueous solution of polyglucin, and a lubricating agent talc. It has been established 
that the volume of foam formed from a model tablet reaches 12 cm
3
and decreases with 
an increase in the content of citric acid. The maximum foam volume is formed when the 
content of citric acid in the model tablet is 22.5%. The effective foaming time is 9 
minutes. To increase the foam volume when combining drugs with a model tablet, we 
chose Na-CMC and polyacrylamide. The volume of foam formed from a model tablet 
when polyacrylamide is used as a moisturizer reaches up to 8.4 cm
3
. With an increase in 
the amount of citric acid in the composition of the model, foaming decreases. An 
abnormal foaming pattern is observed in a 10% aqueous solution of polyacrylamide, 
where foaming reaches up to 40.8 cm
3
, but with an increase in the amount of citric acid 
in the tablet to 29%, it decreases to 10.8 cm
3
). Apparently, in this case, the determining 
role is played by a high concentration of polyacrylamide, which creates a viscous 
environment, which favors the formation of abundant foam. At the same time, the time 
of complete disintegration of the tablet also increases, which reaches 30 minutes. It 
should be noted that when medicinal substances are added to the model tablet, foaming 
decreases sharply. 
And in this case, the reason for this, apparently, is a sharp increase in the viscosity of 
the medium, which confirms the increase in the time of complete disintegration of the 
tablet to 39 minutes. The above was confirmed when using polyacrylamide with a 
molecular weight of 54,000 as a humidifier. These data indicate that water-soluble 
polymers polyacrylamide and Na-CMC are suitable as additives in the preparation of 
foaming tablets and they have a number of advantages over polyglucin recommended in 
the literature. 

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Poster presentation 
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