Organizing co mmittee

 
 

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Poster presentation 
214 
SEPARATING CYTISINE DERIVATIVES IN THIN LAYER OF 
CHITOSAN-SILICA NANOHYBRID SORBENT 
 
D.Sh. Shakarova., Ch.K. Begimkulova., A.B. Ibragimov. 
 
Institute of General and inorganic chemistry, Academy of Science of the Republic of 
Uzbekistan, Republic of Uzbekistan, Tashkent 
 
There are a variety of sorbents (aluminum oxide, silica gel, and modified silica gel 
by various grafted alkyl and functional groups) are used for analysis by thin layer 
chromatography. Despite the variety of derivative sorption materials, the improvement 
of existing and the search for new sorbents does not lose its relevance. 
In particular, nanohybrid polymer–silica sorbents are obtained by the sol-gel method 
with the inclusion of biopolymers into the hydrolytic polycondensation of 
polyethoxysilane oligomer are of interest. The inclusion of chitosan in this process 
seems to offer much promise and chitosan is an ionogen polysaccharide containing a 
functional - NH
2
and - CONH
2
groups capable of interacting with silanol groups of 
silica formed during the sol-gel process. 
The aim of this work was to investigate the possibility of using synthesized 
chitosan/silica sorbent for the separation of cytisine alkaloid and some of its derivatives. 
For separating cytisine and its derivatives, we used the chitosan–silica nanohybrid sorbent 
(CS) and microspherical silica (MSS) gel with 5 µm as a reference. Chromatography in thin 
layers of these sorbents showed high separation selectivity. (Fig. 1). 
On the chitosan–silica nanohybrid sorbent’s selectivity was higher than on MSS. 
These results suggest that the chitosan–silica sorbent should be given preference and 
recommended for controlling the synthesis of alkaloids, their identification, and 
preparative separation of the components of reaction mixtures.