Organizing co mmittee

1
) 
was synthesized by etherification of oxalic acid with propargyl alcohol. The 
corresponding mono- (
2,3
) and bis-1,2,3-triazole derivatives (
4,5
) were synthesized by 
cross-ringing the obtained ether with 
para
-bromo and 
para
-nitrophenylazides. 
Experiments were carried out by heating a mixture of ester and azide in a ratio of 1:1 or 
1:2 in a toluene solution in the presence of catalyst of copper (I) iodide for 8 hours. 
 
The structures of the obtained triazole derivatives (
2-5
) were confirmed using IR and 
1H NMR spectra. 
References 
1.
H.K. Li, J.Z. Sun, A.J. Qin, B.Z. Tang. 
Chin J Polym Sci Engl Ed.
, 2012, 30, P.1–
15 
2.
B.F. Abdel–Wahab, E. Abdel–Latif, H.A. Mohamed, G.E.A. Awad. 
Eur. J. Med. 
Chem.
2012. V52. P. 263-267 
3.
I.A. Аbdugafurov, F.B. Qirgizov, I.S. Ortikov 
European Journal of Chemistry, 
2021, № 12 (1), P.13-17. 

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Poster presentation 
241 
CATALYTIC SYNTHESIS OF 1,4-DISUBSTITUTED
1,2,3-TRIAZOLES BASED ON ORTHO-
PROPARGYLOXYBENZALDEHYDE AND SOME AROMATIC 
AZIDES 
I.S. Ortikov
1
, I.A. Abdugafurov
2
, B.Zh. Elmuradov
1
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
2) National University of Uzbekistan.
e-mail: [e-mail] 
Nowadays, one of the important task is targeted synthesis of promising substances 
based on the reaction of potentially active heterocyclic compounds, especially five- and 
six-membered ring substances containing two or more heteroatoms, with electrophilic 
and nucleophilic reagents and creating effective biologically active drugs based on 
them. In particular, scientific research is being carried out on obtaining new derivatives 
of 1,2,3-triazoles using modern organic synthesis methods. 
It is known that organic azides undergo a 1,3-bipolar cycloaddition reaction with 
substances containing triple bonds and form a 1,2,3-triazole ring. It was discovered by 
M. Meldal and B. Sharpless a catalytic method of cyclization, which today is called as 
“click chemistry”. Scientists received the Nobel Prize in 2001 and 2022 for this 
research. The fact that the authors were awarded 2 times for the method of azide-alkyne 
cycloaddition shows that there is a high interest in this direction [1-3]. 
We started our research by alkylating salicylaldehyde with propargyl bromide and 
synthesized the corresponding ortho-propargyloxybenzaldehyde (1). It was studied the 
cyclization reaction of 1 with 4-nitrophenylazide, 2-methyl-4-nitrophenylazide, 2-
bromo-4-nitrophenylazide (
2-4
). Experiments were carried out in the presence of 
catalysts Cu(AcO)
2
and sodium ascorbate (SAA) in the ratio: 
n
-PrOH : H
2
O (3:1). 
The progress of the reaction was monitored by TLC and the optimal conditions for 
the formation of 1,2,3-triazoles were determined. The structure of the obtained triazole 
derivatives (
5-7
) was confirmed by IR and 
1
H NMR spectra. Compounds, consisting 
formyl group can serve as synthons for further researches.