Organizing co mmittee

1
) under alkaline 
conditions, which gives of N-propylbenzoxazoline (
2
). Its chlorosulfonylation occured 
by 
electrophilic 
substitution 
and 
corresponding 
5-chlorosulfonyl-N-
propylbenzoxazoline (
3
) was obtained. When the synthesized compound 
3
was reacted 
with aliphatic and heterocyclic amines of different basicity in the presence of potash, it 
was observed that corresponding sulfonamides (
4-10
) were formed in good yields: 
The structure of the synthesized compounds was confirmed by the data of IR-, 
1
H 
NMR spectroscopy and mass spectrometry. 
 
References 
1.
S. K. Tipparaju, S. Joyasawal, M. Pieroni, M. Kaiser, R. Brun, and A. P. Kozikowski. 
Journal of Medicinal Chemistry
, 2008, Vol. 51, No. 23, P. 7344–7347. 
2.
A. Akbay, I. Oren, O. Temiz-Arpaci, E. Aki-Sener, and I. Yalçin, 
Arzneimittel-
Forschung
, 2003, Vol. 53, No. 4, P. 266–271. 
3.
M. A. Abdelgawad, A. Belal, and O. M. Ahmed. 
Journal of Chemical and 
Pharmaceutical Research
, 2013, Vol. 5, P. 318–327. 

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Poster presentation 
244 
SYNTHESIS OF NEW POTENTIALLY ACTIVE HYBRID
1-ARYL-3-HETERYLUREAS 
 
G.N. Kudratov, I.S. Ortikov, B.J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail]  
 
Along with cancer and cardiovascular diseases, infectious diseases caused by fungi 
and microbes are among the serious and even fatal diseases [1,2]. For this reason, 
scientists are regularly conducting scientific research on the creation of new drugs for 
the above diseases. Among synthetic organic compounds, various substituted urea 
derivatives are used as anti-inflammatory, cytotoxic and central nervous system diseases 
[3]. Therefore, it is an important task to synthesize new derivatives of various 
substituted urea and to create effective drugs based on them against various diseases. 
In this research work, the synthesis of 1,3-disubstituted ureas was carried out based 
on the reaction of m-tolyl isocyanate (