Organizing co mmittee

A
), the reaction carried out in the presence of acetone/potash; in the 
second method (
B
), in the presence of ethanol/NaOH; in the third method (
C
), in the 
presence of ethanol/NaOH, but experiments were carried out for different time 
durations, with different ratios of reagents. The structure of obtained isomeric dialkyl 
products (
2a
, 
2b
; 
3a
, 
3b
) analyzed by methods of
1
H and 
13
C-NMR spectroscopy and 
fully proved. 
 
References 
1. 
Chen Z. Z. et al. 
Tetrahedron
. 2015. Т. 71. №. 44. P. 8424-8427. 
2. Huber S. et. al. 
Journal of Pharmaceutical and Biomedical Analysis
. 2015. Т. 104. 
P.137-143. 
3. Yoon Y. K. et al. 
European journal of medicinal chemistry
. 2015. Т. 93. P.614-
624. 

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Poster presentation 
247 
CHEMOSELECTIVE ALKYLATION OF
2,6,8- TRIMETHYLQUINAZOLIN-4-ONE 
 
U.M. Yakubov, N.B. Pirnazarova, I.A. Obidova, D.M. Ruziboev,
B.J. Elmuradov
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
Quinazolinones are an interesting class of heterocyclic compounds that are important 
in medicinal chemistry. Compounds of this class have been shown to exhibit 
pharmacological activity such as antimicrobial [1], anti-inflammatory [2] antioxidant [3] 
and anticonvulsant [4]. In addition, compounds of this class are chemically interesting. 
In order to protect the 3N-endocyclic amino group of 2,6,8-trimethylquinazolin-
4(3H)-one (
1
), alkylation reactions with various alkyl halides were carried out. As alkyl 
halides (R-X): ethyl and butyl bromides, amyl, hexyl and heptyl iodides were used: 
Reactions were carried out by boiling a mixture of reagents -