Organizing co mmittee

1
) with various heterocyclic amines containing an 
amino group: 2-aminomackinazolinone (
2
) and bicyclic 2-amino-3-methyl-quinazolin-
4-one (
3
). The reaction was carried out by mixing of 1:1 ratio of isocyanate and amino 
compounds in a solvent medium: 
The reaction was carried out at room temperature in DMF in the presence of potash, 
products (
4,5
) separated by extraction method and products were obtained in high yields 
(
4 
- 87%, 
5 
- 77%) and their structure was confirmed using IR, 1H and 
13
C NMR 
spectra. 
 
References 
1. J. L. Martinez, F. Baquero. 
Microbiol. Rev.
2002, 15, P.647–679,
2. N. Zhang, S. Ma, 
Eur. J. Med. Chem
. 2019, 184, P.111743. 
3. L. Frattaruolo, M. Vega-Holm, M. Carretero-Ledesma, J. Sаnchez-Cеspedes, A.R. 
Cappello, F. Aiello, J. Pachоn. 
Bioorg. Med. Chem. Lett
. 
2020
, 30, 127411. 

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Poster presentation 
245 
SYNTHESIS OF NEW UREA DERIVATIVES BASED ON
2-AMINOTHIOPHENE ESTERS (AMIDE) AND
p-TOLYLISOCYANATE
 
G.N. Kudratov, A.U. Berdiyev, I.S. Ortikov, B.J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
Currently, the creation of synthetic drugs effective against various viral diseases is 
one of the important problems in modern medicine. Medicines prepared on the basis of 
urea derivatives are used effectively in the field of agrochemistry, against tuberculosis, 
microbes and various diseases [1-3]. 
In our work, we aimed to synthesize 4,5-disubstituted-2-aminothiophene derivatives 
with various functional groups based on the Gevald reaction, and synthesize substituted 
ureas based on the reaction of nucleophilic addition of the obtained products with 
p
-
tolylisocyanate, 2-amino-4,5-trimethylenethiophene-3-carboxylic acid ester (