Organizing co mmittee

1
), haplomine (
2
) and 1,4-Bis(3,4-
dimethoxyphenyl)tetrahydro-1
H
,3
H
-furo[3,4-c]furan (
3
) were isolated from the benzene 
layer. The structures of the isolated substances were fully confirmed by IR, 
1
H and 
13
C 
NMR spectroscopic methods and their crystal structures were determined using X-ray 
structural analysis. The isolated substance (
3
) was first identified and isolated from the 
seeds of the plant 
Haplophyllum perfaratum
. This isolated substance is a homologue of 
Yangambin 
- 
1,4-Bis(3,4,5-trimethoxyphenyl)tetrahydro-1
H
,3
H
-furo[3,4-c]furan. 
Yangambin is a natural compound extracted from the bark of Acacia yangambini, and 
yangambin has anti-tumor and anti-inflammatory activities. 
 
 

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Poster presentation 
253 
NITRATION REACTIONS OF QUINOLINE ALKALOIDS 
ANHYDROPERFORINE AND HAPLOPHYLIDINE 
А.U. Ubaydullaev
1
, Sh.N. Zhurakulov
1,2
, V.I. Vinogradova
1
, K.K. Turgunov
1,3
 
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
2) National University of Uzbekistan named after Mirzo Ulugbek, 
3) Turin polytechnic University in Tashkent, Tashkent 100095 Uzbekistan. 
e-mail: [e-mail] 
 
Quinoline alkaloids are of particular importance due to their unique medicinal 
properties and being added as additives to drugs against many diseases. For example: 
Quinine and Quinacrine are used effectively to treat the parasites that cause malaria. 
Carteolol is used to treat arrhythmia and glaucoma. Rosoxacin is used in the treatment 
of respiratory tract, urinary tract, gastrointestinal tract, central nervous system and 
bacterial infections. Considering these properties of quinoline alkaloids, nitration 
reactions of anhydroperforin and haplophyllidine alkaloids synthesized on the basis of 
haplophyllidine alkaloid isolated from the seeds of 
Haplophyllum perforatum
plant 
were carried out in two methods.