Poster presentation
252
ISOLATION OF 1,4-BIS(3,4-DIMETHOXYPHENYL)
TETRAHYDRO-1H,3H-FURO[3,4-C] FURAN
FROM PLANT SEEDS OF Haplophyllum perforatum
А.U. Ubaydullaev
1
, Sh.N. Zhurakulov
1,2
, V.I. Vinogradova
1
, K.K. Turgunov
1,3
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
2) National University of Uzbekistan named after Mirzo Ulugbek,
3) Turin polytechnic University in Tashkent, Tashkent 100095 Uzbekistan.
e-mail: ubaydullayev-aziz@mail.ru
More than 25 alkaloids were isolated from the seeds of
Haplophyllum perforatum
and their structure was studied. Different biological activities
of the isolated alkaloids
have been determined. For example, alkaloid
skimmianine exhibits analgesic, sedative
and estrogenic activities, haplophyllidine alkaloid is also of
special importance due to
its effect on the central nervous system, showing sedative and pain-relieving properties.
Haplophyllum perfaratum
plant seeds collected from Jizzakh
region were extracted in
70% alcohol and then the alcohol was distilled. The remaining aqueous layer was
extracted in benzine. Haplophyllidine (
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