TARGETED SYNTHESES OF SOME NOVEL (E)-1-(4-CHLOROBENZYLIDENE)-2-HETERYLHYDRAZINES A.U. Berdiev, I.S. Ortikov, B.Zh. Elmuradov S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent Thienopyrimidines (TPs) is a biologically important heterocyclic compounds and
attracting attention in medicinal chemistry research since last two decades due to its
diverse range of biological activities. An intensive literature review on TPs and its
derivatives revealed that they were found to possesses different biological activities
such as antitumor, antimicrobial, anti inflammatory, tyrosine kinase and
phosphodiesterases and most of them were patented.
Moreover, TPs have fascinated importance in medicinal chemistry, exhibiting
pharmacological and therapeutic properties such as antidepressant, antihypertensive,
herbicidal and plant growth regulatory properties. Particularly, 4-substituted amino and
hydrazino-TPs was determined excellent, almost equivalent to that of standards
(compared to as potent anticancer drugs), where the presence of electron donating
substituent on both sides of thienopyrimidine ring enhances the activity and electron
withdrawing groups decrease. Also, 4-chlorothieno[2,3-d]pyrimidine is one of the
intermediates for synthesizing anticancer drugs.
In view of the biological importance and the past research of the TPs and its
derivatives, it is worthwhile to synthesize some novel (E)-1-(4-chlorobenzylidene)-2-
heterylhydrazines (
5a-c ):
A systematic approach to the synthesis of targeted compounds was described above.
Poster presentation
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SYNTHESIS OF NOVEL THIENOPYRIMIDINE-
