Organizing co mmittee

5
-60%, 
6
-67%, 
7
-70%, 
8
-69%, 
9
-68%, 
10
-64%
) were obtained. The structure of the obtained 
substances was confirmed based on the results of IR, 
1
H and 
13
C NMR-spectra and X-
ray structural analysis. 
 
References 
1.
Sugden R, Kelly R, Davies S. 
Nature Microbiology
. 2016; 
1
:16187-16187 
2.
Sasmal S, Balaji G, Kanna Reddy HR, et. al. 
Bioorg Med Chem Lett 
2012, 
22:3157–3162 
3.
Khan I, Zaib S, Batool S, Abbas N, Ashraf Z, Iqbal J, et al. 
Bioorganic & 
Medicinal Chemistry.
2016; 
24
:2361-2381 

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Poster presentation 
257 
SYNTHESIS AND INTERACTION OF 6Н(Br)-2,4-
DICHLOROQUINAZOLINES WITH METHYL-PIPERIDINES 
R.Z. Khudoyqulova, I.S. Ortikov, B.J. Elmuradov 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
Quinazoline and quinazolinone derivatives have been studied for a long time due to 
the ease of synthesis and high biological activity. They show good activities in various 
diseases (antimalarial, antioxidant, antidiabetic) [1-3]. Therefore, the development of 
easy and convenient methods for the synthesis of new biologically active 2,4-
disubstituted quinazoline derivatives with different functional groups is one of the 
important issues. 
The purpose of this research work is to determine the improved synthesis methods of 
the synthesis of 2,4-dichloro-6H(bromo)quinazolines, to carry out nucleophilic 
substitution reactions with piperidenes. For this, 6H(bromo)quinazoline-2,4-diones (
1,2
) 
were first reacted with chlorinating agents (POCl
3
+PCl
5
) to give corresponding 2,4-
dichloro-6H(bromo)quinazolines (