Organizing co mmittee

31
and 
20
, which reduced the 
locomotor activity of amphetamine by 64 and 33%, respectively. Substances 
22
and 
13
had no significant effect on amphetamine-induced hyperactivity. Other substances 
enhanced the activity of amphetamine to varying degrees. Substance 
9
was the most 
active among them. The structure-activity relationship was analyzed.
So, among the studied substances, we found agonists and antagonist affected on the 
release of dopamine in the brain caused by the action of amphetamine, which indicates 
the prospects of chemical modifications made in the phenyl group of this series of 
compounds in further development of remedies against alcohol consumption and
Parkinson 
disease.
SnCl
2
2H
2
O
31-33
1
3
5
7
H
3
CO
H
3
CO
NH
2
+
C
Ar
O
H
1
A2-A30
H
+
, 3-4, 
ч
,
t°
H
3
CO
H
3
CO
NH
Ar
2-30
1
3
5
7
H
3
CO
H
3
CO
NH
Ar
7-9
1
'
3
'
5
'
Ar = 
OH
OH
OCH
3
2
3
4
5
NO
2
6
NH
2
OCH
3
9
NO
2
7
Br
OH
16
Br
OH
17
OCH
3
OCH
3
O
2
N
25
OCH
3
OCH
3
Br
24
O
O
O
O
Br
28
Br
OH
OCH
3
26
OCH
3
OH
Br
29
27
2
'
4
'
6
'
O
O
Cl
30
OH
OCH
3
Br
OCH
3
NO
2
23
22
OH
OCH
3
OH
OCH
3
19
20
Br
OCH
3
18
OCH
3
OCH
3
21
Br
12
Br
13
Br
14
Cl
10
Cl
11
31
N
H
3
C
CH
3
15
NH
2
32
NH
2
33
NO
2
8

---

Poster presentation 
256 
SYNTHESIS OF 6H(Br)-2,4-DICHLOROQUINAZOLINES AND 
DIRECTION OF NUCLEOPHILE SUBSTITUTION REACTIONS 
 
R.Z Khudoykulova, I.S. Ortikov, B.J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
Currently, the increase in drug resistance of various disease-causing microorganisms 
requires the creation of new classes of drugs [1]. Among derivatives of quinazoline and 
quinazolinones with different functional groups, it is known from the literature that they 
exhibit high activity against harmful microorganisms. In addition, compounds of this 
class are used for anti-obesity, pain relief, and anti-cancer [2,3]. 
In our study, we obtained the corresponding 2,4-dichloro-6H(bromo)quinazolines 
(
3,4
) by reaction of 6H(bromo)quinazoline-2,4-diones (
1,2
) with chlorinating agents 
(POCl
3
+PCl
5
). We carried out nucleophilic substitution reactions with secondary 
heterocyclic amines: imidazole, benzimidazole and 2-methylbenzimidazole. In our 
previous studies, experiments were conducted with aliphatic and cyclic secondary 
amines in ethanol, and 2,4-disubstituted quinazoline derivatives were obtained. In these 
experiments, when we studied the obtained products, we saw that the active chlorine 
atom in position 4 was not replaced by amine, but replaced by ethanol obtained as a 
solvent, forming the 4-ethoxy group. and it was observed that the heterocyclic amine 
was replaced by the chlorine atom in position 2. We can explain this by the low basicity 
of heterocyclic amines and the high activity of the chlorine atom in position 4 for 
ssubstitution. 
Reactions of 2,4-dichloro-derivatives were carried out in 3,4:Nu - 1:2 ratio in ethanol 
(80
0
C) by heating for 6 hours, and new products were obtained in good yields (