Organizing co mmittee

1
), 2-
amino-4,5-diethylthiophene 
carboxylic 
acid 
ethyl 
ester 
(
2
), 
2-amino-4,5-
pentamethylenethiophene-3-carboxylic acid ethyl ether (
3
) and 2-amino-4,5-dimethyl 
thiophene carboxylic acid amide (
4
) were synthesized and nucleophilic addition of them 
with 
p
-tolyl isocyanate (
5
) was carried out. As a result, N,N'-disubstituted urea 
derivatives (
6-9
) were isolated in high yields: 
The reaction was carried out by mixing of 1:1 ratio of 2-aminothiophene derivatives 
and isocyanate in a solvent medium. The reaction was carried out at room temperature 
in the presence of potash in DMF solution, and the products (
6-9
) were extracted and 
isolated in high yields (
6
-76%, 
7-
74%, 
8
-81%, 
9
-78%). The structure of the synthesized 
urea derivatives confirmed by IR, 
1
H and 
13
C NMR spectra. 
 
References 
1.
C. Morisseau, S. Pakhomova, S.H. Hwang, M.E. Newcomer, B.D. Hammock, 
Bioorganic & Medicinal Chemistry Letters.
2013; 23, 3818–3821. 
2.
G.M. Viana, L.C. Aguiara, J.A. Ferrаo, A.C. Simas, M.G. Vasconcelos. 
Tetrahedron Letters
. 2013, 54, 936-940 
3.
G.D. Francisco, Z.Li, J.D. Albright, N.H. Eudy, A.H. Katz, P.J. Petersen, P. 
Labthavikul, G. Singh, Y. Yang, B.A. Rasmussen
, Bioorg. Med. Chem. Lett.
, 2004, 14, 
235-238. 

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Poster presentation 
246 
SYNTHESIS OF POTENTIALLY ACTIVE ISOMERIC ALKYL-
BENZIMIDAZOLES 
 
B. B. Jurayev, I. S. Ortiqov, B. J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
It is known that, among heterocyclic compounds, benzimidazole and their derivatives 
occupy an important place in terms of theoretical and practical importance [1]. As a 
result of the research, the analysis of the literature shows that various derivatives of 
benzimidazoles have high activity against cancer, anthelmintic drug, anti-malarial, anti-
tuberculosis, and against viruses [2]. Some of the synthesized compounds, for example 
Omeprazole
, 
Bendamustine
, 
Maribavir
are used as effective anti-cancer and anti-viral 
agents [3]. 
We also carried out alkylation reactions of 2-methyl-5-chlorobenzimidazole in order 
to protect the active proton on the nitrogen atom. Propyl chloride and 
iso
-propyl 
bromide were used as alkylating agents and reactions were carried out in different ways. 
In the first method (