Organizing co mmittee

 
Reference: 
Juergens U.R. Anti-inflammatory properties of the monoterpene 1.8-cineole: current 
evidence for co-medication in inflammatory airway diseases. 
Drug Res
(Stuttg). 2014. -
V. 64 (12). - Pp. 638-46.
 
 

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Poster presentation 
77 
FATTY ACIDS AND ESSENTIAL OILS FROM AERIAL PART OF 
Ferula kyzylkumica - AN ENDEMIC PLANT OF UZBEKISTAN 
 
D. Т. Asilbekova, Kh.M. Bobakulov, A.M. Nigmatullaev 
 
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences 
of the Republic of Uzbekistan, 77 M. Ulugbek St., Tashkent, 100170, Uzbekistan,
e-mail: [e-mail] 
 
There are about 40 species of wild 
Ferula
(Apiaceae family) in our region. Seven of 
its species, including the 
Ferula kyzylkumica 
Korovin is listed in the Red Book of 
Uzbekistan. This species is a polycarpic plant and a rare endemic of the remnant 
mountains of Kyzylkum. The objectives of this report were focused on the 
determination of the of fatty acid compositions of lipids
 
and essential oil components 
isolated from the aerial part of 
F. kyzylkumica 
Korovin. 
Air-dried aerial part (100 g)
 
was ground in a coffee grinder. Essential oil (0.0103 g) 
from half of plant material (50 g) was isolated by hydro distillation. For isolation of 
lipids second part of material (50.0 g) extracted with chloroform – methanol (5 x 100 
mL) by Folch method. All extracts were combined, was worked up beforehand with 
aqueous CaCl
2
solution (0.04%) to remove non-lipid components constituents. Extract 
evaporated and lipids underwent alkaline hydrolysis to isolate fatty acids. Fatty acids 
(0.565 g) convert to methyl esters by treatment with freshly prepared diazomethane 
solution in Et
2
O. The conditions for all chemical and GC-MS, GC-FID analyses over 
columns with НР-5 and HP-INNOWax (respectively fatty acid methyl esters and 
essential oil) were analogous as before [1].
The yield of essential oil from aerial part of 
F. kyzylkumica
was 0.23% of the dry 
plant material. The results by GC-MS analysis indicated that the main constituents of 
the essential oil compounds were the sesquiterpene hydrocarbons δ-cadinene, 
germacrene B and D, α-muurolene as well as oxygenated sesquiterpenes such as α-
cadinol, T-cadinol and germacrene-D-4-ol. The content of monoterpenes in the essential 
oil is low. 
Identified acyl fragments of the lipids were dominated by unsaturated constituents 
with linolenic and linoleic acids as the main ones, but oleic acid was significantly less. 
The major saturated acid of the 12:0−22:0 series was hexadecanoic acid. This acid was 
also identified among the volatile compounds of this plant. 
Thus, essential oil and fatty acid profiles of 
F. kyzylkumica
were studied for the first 
time. 
Reference: 
D. T. Asilbekova, G. Ozek, T. Ozek, Kh. M. Bobakulov, A. M. Nigmatullaev, Sh. 
Sh. Sagdullaev, 
Chem. Nat. Compd.
, 58, 217–221 (2022). 

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Poster presentation 
78