Organizing co mmittee

 
References 
1. Mohammadhosseini M., Venditti A., Akbarzadeh A. The genus 
Perovskia
Kar.: 
ethnobotany, chemotaxonomy and phytochemistry: a review. Toxin Reviews.
 
2021. V. 
40 (4). Pp. 484-505.
 
 
 

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Poster presentation 
76 
COMPOSITION OF ESSENTIAL OIL AND PHENOLIC 
COMPOUNDS OF Lophanthus schtschurowskianus 
O.K. Askarova
1
, E.Kh. Botirov
2
, Kh.M. Bobakulov
2
, A.A. Ganiev
2
, 
N.K. Usmanova
3
 
1)
 
Namangan Institute of Engineering and Technology, Namangan, Uzbekistan 
2)
 
S.Yu.Yunusov Institute of the Chemistry of Plant Substance, Academy of Science of the 
Republic of Uzbekistan, 
e-mail: [e-mail] 
3) Namangan State University, 
Namangan, Uzbekistan 
Lophanthus
is a genus of perennial herbaceous plants of the 
Lamiaceae
family, 
represented by more than twenty species growing in alpine or highland areas. Four 
species of plants of this genus grow in the territory of Uzbekistan. We studied the 
component composition of essential oil obtained by hydrodistillation from an air-dry 
above-ground part of the 
Lophanthus schtschurowskianus
(Regel) Lipsky plant growing 
in Surkhandarya region of Uzbekistan. By the GC-MS method, 57 components were 
identified in the composition of the essential oil, which is 93.8 % of the total amount of 
the oil, including 52 volatile compounds. The main components of the essential oil are 
1,8-cineol (13.4%), viridiflorol (8.5%), α-terpineol (4.3%), terpinen-4-ol (4.2%), τ-
cadinol (4.1%), β-spatulenol (3.9%), α-p-dimethylstyren (2.1%). The essential oil is 
dominated by oxidized monoterpenes (33.6%) and oxidized sesquiterpenes (24.7%), 
also detected compounds belonging to sesquiterpene hydrocarbons (8.6%). Essential oil 
contains an insignificant amount of monoterpene hydrocarbons (3.9%). In qualitative 
and quantitative composition of components, the essential oil of 
L. schtschurowskianus
significantly differs from the essential oils of other studied plant species of the genus 
Lophanthus.
1,8-Cineol has moderately pronounced anti-exudative and cytotoxic activity, and is 
also characterized by analgesic and antitumor properties. It is used for chronic and 
inflammatory respiratory conditions such as bronchitis or respiratory tract colds, as well 
as asthma and hay fever [1].
Four phenolic compounds were isolated from various fractions of a 75% alcohol 
extract of the above-ground part of 
L. schtschurowskianus,
and identified with phenyl- 
propanoids caffeic acid, rosmarinic acid, nepotidin B and flavone luteolin based on the 
study of 
1
H, 
13
C NMR, HSQC and HMBC spectra. 
Rosmarinic acid is characterized by immunomodulatory, anti-inflammatory, 
antimicrobial, antioxidant, neuroprotective, and antidiabetic activities. Luteolin has anti-
inflammatory, antioxidant, anticarcinogenic, and cytotoxic effects against tumor cells 
and enhances the effect of anticancer drugs. Nepetoidin B was shown to have greater 
antioxidant activity than gallic, rosmarinic, and caffeic acids and showed activity as an 
insect phagostimulant.