Organizing co mmittee

A NEW ANTI-HELMINTH COMPOSITION
 
I.D. Shamʹyanov, Zh.I. Islamova, M.A. Mamatkhanova,
R.F. Mukhamatkhanova, D.E. Dusmatova, V.N. Syrov 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
The problem of treatment and prevention of helminthiasis is one of the topical in the 
world medical practice. Because of their hepatotoxic and immunotoxic effects, the 
widely used synthetic agents are of limited use, especially in children’s practice and for 
patients with hepatobilar disorders.
In this connection, a new anti-helminth composition based on purified sums of 
sesquiterpene lactones of plants 
Artemisia annua
L., 
Inula grandis
L. and 
Tanacetum 
pseudoachillea
C. Winkl., which has not been shown to have the above mentioned side 
effects, was created. The new composition with conditional name «Helminthabs» 
includes in addition to lactones, auxiliary components - microcrystalline cellulose and 
crystal medical glucose. The results of screening studies for the presence of pronounced 
anti-helminth activity of "Helminthabs" in comparison with the widely used 
antihelminth drug "Antihelminth" are given in tables 1 and 2. 
Table 1 
Exprassiveness of dwarf tapeworm infection activity of preparations
«Helminthabs» and «Antihelminth» (М±m, n=10) 
Experimental 
conditions 
Dose, 
mg/kg 
Number of parasites 
detected after autopsy, 
individual 
р 
Intens-
efficiency, % 
Control 
- 
16,8±2,1 
- 
- 
Helminthabs 
50 
100 
0,9±0,31 
0,5±0,22 
<0,001 
<0,001 
94,6 
97,0 
Antihelminth 
500 
6,9±1,6 
<0,001 
60,7 
Table 2 
Exprassiveness of antiaspikulurosic activity of preparations
«Helminthabs» and «Antihelminth» (М±m, n=10) 
Experimental 
conditions 
Dose, 
mg/kg 
Number of parasites 
detected after autopsy, 
individual 
р 
Intens-
efficiency, % 
Control 
- 
51,6±6,6 
- 
- 
Helminthabs 
50 
100 
0,2±0,13 
0 
<0,001 
<0,001 
98,8 
100,0 
Antihelminth 
500 
25,5±3,42 
<0,002 
51,7 
The presented data show that the created new anthelminthic composition has a high 
anticestodal and antinematodal activity, exceeding the known drug «Antihelminth».