Organizing co mmittee

2
) in 65% yield required for the reactions: 
Reaction of 6-aminoquinazolin-4-one (
2
) with cyanuric acid in a ratio 1:1 gives 
targeted 
mono
-substituted 6-((4,6-dichloro-1,3,5-triazin-2-yl)amino)quinazolin-4(3H)-
one (
3
) in excellent yield (93%). Melting point of 
3
is 348-350
°
C. Experiments on the 
synthesis of di- and trisubstituted triazines are ongoing. 
Structure of the product has been proven using physical methods of the research. 
 
References
1. Kulikova N.F. 
Herbicides and ecological aspects of their Application
: Textbook. 
M: Book house "LIBROKOM", 2010. 152 p. 
2. Martynenko V.I., Promonenkov V.K., Kukalenko S.S., Volodkovich S.D., 
Kasparov V.A. 
Pesticides
: A Handbook. -M.: Agropromizdat, 1992. 368 p. 
3. Medved L.I. 
Handbook of pesticides
/ Team of authors, ed. Professor Medved L.I. 
-K.: Harvest, 1974. 448 p.

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Poster presentation 
230 
TARGETED SYNTHESIS OF
3-ALKYL-6-NITROBENZOPYRIMIDIN-4-ONES 
 
F. A. Zulpanov,
1
 B. J. Elmuradov,
1
 D. M. Ruziboev,
1
B. A. Sobirov
2
, J. O‘. Muyassarov
3
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
2) Mirzo Ulugbek
 
National University of Uzbekistan, Faculty of Chemistry 
3) Samarkand State University, University blv. 15, Samarkand 140104, Uzbekistan
Compounds containing a condensed pyrimidine ring are widely used in agriculture 
and medicine. They are widely used in the treatment of cardiovascular, diabetes, cancer 
and viral diseases. In recent years, drugs such as 
imatinib, erlotinib,
and 
afatinib
, 
created on the basis of benzopyrimidine derivatives, have been used against tuberculosis 
and cancer. They are approved by the Food and Drug Administration (FDA) in the 
United States. Today, the demand for low-toxic drugs containing a new type of 
pharmacaphor group in the molecule is increasing year by year [1,2]. 
Taking into account the above points, it is very important to carry out the targeted 
synthesis of substances containing the potentially biologically active benzopyrimidine 
ring and their chemical modification, as well as to determine their physico-chemical and 
biological properties and create new drugs based on this. 
In the course of our research, we synthesized the desired benzopyrimidin-4-one (
1
) in 
the presence of formamide with 
o
-aminobenzoic acid, and carried out its alkylation 
reaction with 
various 
normal 
and 
iso
-structured alkyl halides, 
and 3-
alkylbenzopyrimidin-4-ones (
2-14
) were obtained in high yields: 
In order to expand the synthetic potential of the synthesized 3-alkylbenzopyrimidin-4-
ones, we performed electrophilic substitution (nitration) reactions in their aromatic ring. The 
reactions were carried out at low temperature in the presence of a nitrating mixture 
(HNO
3
/H
2
SO
4
). As a result, 3-alkyl-6-nitrobenzopyrimidin-4-ones (