Organizing co mmittee

15-27
) were synthesized 
in excellent yields. Their structure was confirmed by IR, NMR spectroscopy and X-ray 
structure analysis. 
References
1. V. Alagarsamy, K. Chitra, G. Saravanan, V. Raja Solomon, M.T. Sulthana, B. 
Narendhar, An overview of quinazolines: Pharmacological significance and recent 
developments // 
European Journal of Medicinal Chemistry
. 2018, 10; 151:628-685 p. 
doi: 10.1016/j.ejmech.2018.03.076. 
2. A. Ward, L. Dong, J.M. Harris, K.K. Khanna, F. Al-Ejeh, D.P. Fairlie, et al. 
Quinazolinone derivatives as inhibitors of homologous recombinase // 
Bioorganic & 
Medicinal Chemistry Letters
. 2017; 27(14):3096-3100 p. 

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Poster presentation 
231 
SYNTHESIS AND PROPERTIES OF CHITOSAN CITRATE
Bombyx mori 
Z.I. Ibodullaeva, K.K. Pirniyazov, S.Sh. Rashidova 
 
Institute of Chemistry and Physics of Polymers, Tashkent, st. A. Kadyri, 7b, Republic of 
Uzbekistan,
e-mail: [e-mail], 
tel: [phone] 
In this work, obtaining the synthesis of chitosan citrate 
Bombyx mori
based on citric 
acid and chitosan by the suspension method. Its physicochemical and antimicrobial 
properties against 
Fusarium oxysporum
, which causes diseases of mulberry trees, have 
been studied. The resulting chitosan citrate based on chitosan 
Bombyx mori
(CS) and 
citric acid (CA) has a larger suppression zone compared to all variants against 
Fusarium 
oxysporum
mulberry culture, which makes it possible to use it in presowing seed 
treatment at a ratio of CS: CA components of 4:1. IR spectroscopy and X-ray diffraction 
analysis established the structural characteristics of chitosan citrate 
Bombyx mori
.
In order to obtain biologically active complexes of chitosan with citric acid, the 
synthesis was carried out at a temperature of 25
0
C by varying the ratio of the initial 
components of chitosan and citric acid. The duration of the synthesis is 60 minutes. 
Acetone of chemically pure grade was used as a desiccant. The amount of citric acid in 
the composition of chitosan citrate was determined by alkaline titration in the presence 
of the phenolphthalein indicator. The complexation was carried out by the suspension 
method of mixing the components of chitosan and СA at a ratio of 1:1, 2:1, 3:1, 4:1. 
The degree of binding of citric acid was determined based on the ratio (M 
СA
) exp. / (M 
СA
) calc.
The results obtained are presented in table. 
Table 
Influence of the ratio of the initial components of chitosan and СA 
on the degree of binding citric acid 
The results obtained show that with an increase in the ratio of chitosan compared to 
citric acid, the content of citric acid in the composition of the obtained chitosan citrate 
decreases by reducing the proportion of citric acid in the reaction system. It was found 
that with an increase in the ratio of chitosan, the yield of the final product and the 
degree of binding of citric acid increase. Note that after the establishment of an 
equivalent ratio of amino groups of chitosan and carboxyl groups of citric acid (at a 
ratio of components of chitosan: СA 3:1), the degree of binding and the yield of final 
products change slightly.