Organizing co mmittee

TARGETED SYNTHESIS OF HYDRAZIDES, CONTAINING A 
PHARMACOPHORIC - BENZOXAZOLE CYCLE 
 
Z.J. Pulatova, I.S. Ortikov, B.J. Elmuradov
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail]  
 
Benzoxazole derivatives are important heterocyclic organic compounds, with which 
research began many years ago. One of the main reasons for this is explained by the fact 
that they have important biological and pharmacological activities [1]. This class of 
compounds includes analgesics, antivirals, fungicides, anticancer, bactericides, and 
anthelmintics [2]. 
It should also be noted that various biologically active substances have been found 
among hydrazides. For example, they include anti-tuberculosis (isoniazid, ftivazid), 
plant growth regulators (maleic acid hydrazide) – as retardants. 
Our main goal in this work is to search for an efficient synthesis method of 2-
hydrazinobenzoxazole (
1
) and to carry out acylation reactions of the obtained 
compound with some aromatic acid chlorides. 
To achieve these goals, we carryied out acylation reactions of 2-
hydrazinobenzoxazole (
1
) with acid chlorides containing various substituents under 
simple and convenient conditions and it was synthesized the corresponding hydrazides 
(
2-5
) in good yields: 
Reactions were carried out in the presence of triethylamine in benzene solution.
The structure of the synthesized hydrazides (
2-5
) was proved using IR-, 
1
H and 
13
C 
NMR methods and confirmed based on the results of elemental analysis. 
 
References
1.
Chilumula N.R., Gudipati R., Ampati S., Manda S., Gadhe D. 
Int. J. Chem. Res.
2010. Vol.1. Issue 2. P.1–6. 
2.
Ryu C.K., Lee R.Y., Kim N.Y., Kim Y.H., Song A.L. 
Bioorg. Med. Chem. Lett.
2009. Vol.19. Issue 20. P.5924–5926. 

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Poster presentation 
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