Organizing co mmittee


Method(I): haplophyllidine ( 1



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Abstracts ICPS 2023

Method(I):
haplophyllidine (
1
) alkaloid was dissolved 
in concentrated acetic acid and nitration mixture (HNO
3
+CH
3
COOH) was added while 
stirring. The reaction was carried out at a temperature of 65-70℃ for 6 hours. As a 
result of the reaction, a mixture of substances anhydroperforin (
2
)and 7-methoxy-3,3-
dimethyl-9-nitro-2,3-dihydro-1H-furo[2,3-b]pyrano[2,3-h]quinolone (
3
) (2:1) was 
formed. 
Method(II): 
anhydroperforin (
2
) was dissolved in concentrated acetic acid and 
nitration mixture (HNO
3
+3H
2
SO
4
) was added while stirring. The reaction was carried 
out at 65℃ for 4 hours. The progress of the reaction was monitored using the TLC 
method. The structure of the product was fully proven using 
1
H and 
13
C NMR 
spectroscopic and X-ray structural analysis methods. 
N
O
O
H
3
C
H
3
C
O
CH
3
O
CH
3
Method(II)
(HNO
3
+3H
2
SO
4

N
O
O
H
3
C
H
3
C
O
CH
3
N
O
2
N
O
O
CH
3
O
CH
3
H
3
C
H
3
C
H
O
Method(I)
(HNO
3
+CH
3
COOH) 
+
1
2
3


Poster presentation 
254 
QUERCETIN AMINOMETHYLATION WITH 
TETRAHYDROISOQUINOLINE DERIVATIVES AND 
BIOLOGICAL ACTIVITY OF THEIR CONJUGATES 
 
Sh. N. Zhurakulov

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