Organizing co mmittee

 
 

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Poster presentation 
322 
BIOLOGICAL ACTIVITY OF THE OIL EXTRACT OF Curcuma 
longa HARVESTED IN SURKHANDARYA REGION 
 
M.R. Tursunova
1
, B.R. Umarov
1
, A.B. Soliev
2
, U.K. Inogamov
1 
 
1) Tashkent Scientific Research Institute of Vaccines and Serums, Uzbekistan, 
100084, Tashkent, Yunusabad district, Chingiz Aitmatov str.,
phone:[phone], 
e-mail:[e-mail]
 
2) Turin Polytechnic University in Tashkent, 
100095, 17 Little Ring Road, Tashkent, Uzbekistan, phone; ([phone] 
 
One of the promising and dynamically developing areas of modern medicine and 
pharmacy is the appeal to food plants as a source of biologically active compounds 
(BAC). 
Curcuma Longa
is a valuable source of BAC with diverse biological activity. 
The nutritional and medicinal value of turmeric is associated with a high content of 
curcuminoids – heptadiene compounds of phenolic nature (at the level of 2-4%, but may 
also exceed 5%); the essential oil component of BAC also deserves attention. Turmeric 
rhizomes serve as raw materials for obtaining a number of medicines, such as "Holiver", 
"Hepatofalk plant", "Holagogum", cough syrup "Suprima-broncho". The purpose of this 
work is to study the biological activity of an oil extract from the rhizome of 
Curcuma 
Longa
. 
To achieve the goal, the root part of the plant grown in Surkhandarya region was 
extracted. The extraction was carried out with hexane. A comparative analysis to 
determine the antioxidant activity of the oil extracts of local and Indian origin of 
Curcuma Longa
was carried out on white rats. It is known that paracetamol hepatitis 
increases the activity of free radicals and as a result increases the level of the secondary 
product of lipid peroxidation – malondialdehyde (MDA). The level of MDA was 
determined in a model of paracetamol hepatitis. For the experiment, 24 white male rats 
with a body weight of 180-200 g were taken and divided into 4 groups. The control 
group - intact - received purified water, the experimental group received a single 
intragastric paracetamol at a dose of 1000 mg/ kg, and the 3
rd
and 4
th
group of rats 
received intragastric paracetamol with turmeric oil extract of 
Curcuma Longa
from 
Surkhandarya and India for 3 days. The obtained results showed that the compared 
extracts suppress free radical processes in the body. The results of the experiment are 
shown in the table. 
Table 
№ 
Groups 
MDA, nmol/ml 
1 
Control - Intact 
2.42±0.23* 
2 
Experimental 
3.74±0.26 
3 
Experimental - Oil extract of 
Curcuma Longa
from Surkhandarya region 
2.92±0.28 
4 
Experienced - Turmeric Long India Oil Extract 
2.32±0.08* 
(Note:*- the difference in the reliability index at P<0.05 in comparison with the intact group.) 
Conclusion: Experimental study of turmeric oil extract of 
Curcuma Longa
from 
Surkhandarya, has an antioxidant effect. 
 

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Poster presentation 
323