Organizing co mmittee

US-16
exhibited active herbicidal 
properties at a concentration of 0.1%: 
 
References: 
1. http://latifundist/com/read/2291.Chemical analysis: analytics of the world market 
of plant protection products. 4.12.2018. (in Russian). 
2. Zhemchuzhin S.G., Spiridonov Yu. Ya., Bosak G.S. Nanotechnologies and 
pesticides. Agrochemistry. 2019. No. 11. P. 77–85 (in Russian). 
3. Rakitin Yu.V. and Rudnik V.E. Methods for determining growth regulators and 
herbicides, L., “Science”, 1966, pp. 182-197. (in Russian). 

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Poster presentation 
324 
ACUTE TOXICITY TESTING OF NATIVE AND MODIFIED 
FORMS OF IMMUNOPARAZITAN-N 
 
B.I. Mamatkulov 
 
Tashkent Research Institute of Vaccines and Serum Uzbekistan,
100084, Tashkent, st. Chingiz Aitmatov, 37 
 
Immunoparasitan N is a chemically modified complex of polysaccharides and 
lipoproteins isolated from fungi. In appearance, it is a light gray suspension intended for 
intramuscular injection. The drug activates the system of antiparasitic immunity, 
including the cytotoxic activity of macrophages, eosinophils, neutrophils, as well as 
activating the production of antibodies. 
To enhance the immunobiological properties of the drug, its structure was modified 
with iron and cobalt ions. It was found that this modification increased the biological 
activity of the drug (increased phagocytic activity in mice). However, the acute toxicity 
of the drug increased significantly compared to the original form. These changes were 
expressed in a decrease in body weight by 12,2 + 0.23% and 8,6 + 0.17%, respectively, 
as well as in a decrease in motor activity and an orienting reflex in the first 7 days after 
the administration of the modified compound. 
Thus, the modification of Immunoparasitan-N preparation with metal ions can 
enhance the indicators of their acute toxicity.