Organizing co mmittee

RESEARCH OF HEPATOTROPIC BİOLOGİCALLY ACTİVE 
SUBSTANCES 
 
Eldar Garayev, Sara Pashayeva 
 
Azerbaijan Medical University, Pharmaceutical Toxicology and Chemistry 
Department, 
Anvar Gasimzade str. 14, AZ1022 Baku, Azerbaijan 
 
The liver is considered one of the organs that carry out very important functions in 
the human body. Also, the liver is called the "chemical laboratory" of the body, as it 
plays a leading role in the body in eliminating of toxic substances. The main organ 
where xenobiotics are biotransformed is the liver. As a result of liver functional 
disorder, lipid peroxide oxidation, inhibition of protein synthesis, changes in bile 
formation and secretion, adverse effect on the course of immunological reactions, 
disturbance of calcium homeostasis, etc. such cases may occur. Such functional 
disorders include fatty liver, fibrosis or necrosis, carcinogenesis, cirrhosis, etc. leads to 
these pathologies. The main purpose of our research is synthesizing and studying 
representatives of more effective hepatotropic substances for the treatment of liver 
diseases caused by various reasons. Purine alkaloids (caffeine, theobromine, 
theophylline) obtained from tea and coffee waste have been intended as sources of 
natural compounds. The sum of alkaloids was obtained from these plant wastes by the 
general isolation method of alkaloids with 90% ethyl alcohol, and individualized with 
the help of flash chromatography. Hydrolysis of individualized caffeine, theobromine 
and theophylline alkaloids was separately carried out with 40% KOH solution (for 
obtaining hepatotropic derivatives). The obtained synthetic derivatives were re-
individualized by the preparative method and identified by UV and IR spectroscopy 
methods. The biological activity of purine alkaloid derivatives was studied by 
in silico
computer programs (PASS Online, Swiss TargetPrediction) and the presence of various 
interesting biological effects was discovered. Among these derivatives, theophyllidine 
differs from the other two derivatives by having hepatotropic effect. Researches are 
continued in this direction. The results are presented in a comparative table. 
Table. 
In silico
biological activities of synthetic derivatives of purine alkaloids 
Synthetic derivatives of purine alkaloids 
Theophyllidine 
Caffeidine 
Theobromidine 
Biological activity 
% 
Biological 
activity 
% 
Biological activity 
% 
Hepatic 
disorders 
treatment 
8
7 
Vascular 
endothelial growth 
factor antagonist 
9
5 
Vascular endothelial 
growth factor antagonist 
9
3 
Phobic 
disorders 
treatment 
7
2 
Vascular 
endothelial growth 
factor 2 antagonist 
9
4 
Vascular endothelial 
growth 
factor 
2 
antagonist 
9
3 
Nucleotide 
metabolism regulator 
6
5 
Kidney function 
stimulant 
6
4 
Kidney 
function 
stimulant 
6
1 
Mannotetraose 
2-
alpha-N-
acetylglucosaminyl-
transferase inhibitor 
6
6 
Phobic disorders 
treatment 
6
7 
Phobic 
disorders 
treatment 
7
5 

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Poster presentation 
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