Organizing co mmittee

LIGAND SYNTHESIS FOR TARGETED DEGRADATION OF 
SARS CoV-2 NSP14 
 
Maria А. Zakharova, Mikhail V. Chudinov 
 
MIREA - Russian Technological University, 86 Vernadsky avenue, Moscow, Russia 
The technology of targeted protein degradation (Protac©) is based on the production 
of chimeric molecules consisting of 2 ligands to various biological targets: to the 
element of the proteasome complex ligase E3 and to the target protein. The ligands are 
interconnected by a spacer. As a result of the action of such a chimeric molecule, the 
target protein is labeled by the E3 ligase as a target of the proteasome complex of the 
cell and is further destroyed by the proteasome. This new technology has already proven 
itself in the creation of antitumor drugs, but its use in the fight against viruses is just 
beginning [1]. Based on the recently developed inhibitors of the nonspecific protein 
nsp-14 of the SARS-Cov2 virus [2], we synthesized chimeric compounds 
Cov3 
and
 
Cov4
, potentially suitable for use in Protac technology to combat SARS-Cov2 
(Schema1)
. 
1. Desantis J., Goracci L. Proteolysis targeting chimeras in antiviral research. Future 
Med Chem. 2022;14(7):459-62. doi: 10.4155/fmc-2022-0005. 
2. Ahmed-Belkacem R., Hausdorff M., Delpal A., Sutto-Ortiz P., Colmant A.M.G., 
Touret F., et al. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by 
Sulfonamide-Based Bisubstrate Analogues. J Med Chem. 2022;65(8):6231-49. doi: 
10.1021/acs.jmedchem.2c00120. 

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Poster presentation 
63 
GROWTH AND BIOCHEMICAL CHARACTERISTICS OF 
WINTER WHEAT SEEDLINGS AFTER SEED TREATMENT 
WITH CONJUGATE CHITOSAN-CAFFEIC ACID 
J.N. Kalatskaja1, N.A. Laman1, K.M. Herasimovich1, K.I. Rybinskaya1,