OA -treatment. We had
ascertained
OA -induced apoptosis as being attributed to activation of caspase cascade:
it was simultaneously associated with extrinsic and intrinsic pathways mediated by
activation of caspases-8,-9,-3,-6,-7 and cleaved-poly-ADP ribose polymerase (PARP) in
HBL-100 cells. As opposed to that, an increase of only activated caspase-9 associated
with intrinsic pathway of cell death and the emergence of caspase-6 and cleaved-PARP
without caspase-3,-7 activation was found in HBL-100/Dox cells. Thus, cytotoxic
activity of
OA was attributed to induction of cell apoptosis in HBL-100 and HBL-
100/Dox cancer cells.
This work was financially supported by the Russian Science Foundation (grant No.
21-13-00161).
References:
1. Nazarov M.A.; Tolmacheva I.A.; Eroshenko D.V.; Maiorova O.A.; Dmitriev
M.V.; Grishko V.V. Synthesis of 1,2-Azole Derivatives on the Basis of α,β-Unsaturated
Triterpene Aldehydes.
Chem. Heterocycl. Compd .
2020 , 56, 1321–1328
2
. Moiseeva N.; Eroshenko D.; Laletina L.; Rybalkina E.; Susova O.; Karamysheva A.;
Tolmacheva I.; Nazarov M.; Grishko V. The molecular mechanisms of oleanane aldehyde-β-
enone cytotoxicity against doxorubicin-resistant cancer cells.
Biology .
2023 (in Press)
Poster presentation
61
STUDY OF THE ALKALOID COMPOSITION OF THE ROOTS OF THE PLANT THALICTRUM MINUS L. FROM THE FLORA OF AZERBAIJAN Ilkin. U. Nasirli*; Eldar. A. Garaev; *Department of Pharmaceutical toxicology and chemistry, Faculty of Pharmacy, Azerbaijan Medical University, Nasimi district, Enver Qasimzade 14. AZ1022, Baku, Azerbaijan, E-mail: ilkinnesirli92@gmail.com
