Organizing co mmittee

TRACHELANTIC ACID FROM Rindera oblongifolia 
R.M. Ruzibaeva, N.I. Mukarramov, A.R. Khurramov, Kh.M. Bobakulov 
. 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
There are 8 species belonging to the 
Rindera
genus in Central Asia. 
Rindera 
oblongifolia
M. Popov is an endemic species widely distributed in the mountain and 
sub-mountain regions of Central Asia. This plant grows, in the Pskem mountain and 
sub-mountain regions of the Tashkent region of Uzbekistan [1]. In our previous work, 
four alkaloids: exinatine, N-oxide trachelantamine as well as new alkaloids rinderidine 
and oblongifolidin were isolated from 
R. oblongifolia
M. Popov [2]. 
Secondary metabolites of 
R. oblongifolia
M. Popov collected from the Tashkent 
region were extracted in 80% ethyl alcohol using an ultrasonic extractor. The obtained 
alcohol extract was divided into four parts: chloroform, ethylacetate, n-butanol and 
water part., A white powdery substance was isolated by column chromatography using 
silica gel (100-160 μm) and eluting with chloroform: methanol (100:2) from fractions 
60-71 of the ethyl acetate part. The temperature of melting point was 70-71OC. The 
chemical structure of isolated compound was established as trachelantic acid by 1D and 
2D NMR spectroscopy and mass-spectrometry. 
Structure of trachelantic acid 
Trachelantic acid was first time isolated from the 
Rindera oblongifolia
M. Popov. 
References
1. Vvedenskiy A.I.1961. Flora of Uzbekistan, Vol. 5, Tashkent: Publ. Acad. Nauk 
UzSSR; pp 196-202. Russian 
2. R. M. Ruzibaeva, Kh. M. Bobakulov, N. I. Mukarramov, B. Tashkhodzhaev, R. 
Ya. Okmanov, A. M. Nigmatullaev & N. D. Abdullaev “Rinderidine and 
oblongifolidine new pyrrolizidine alkaloids from 
Rindera oblongifolia
M. Popov and 
their 
absolute 
configurations“. 
Natural 
Product 
Research, 
DOI: 
10.1080/14786419.2022.2134865