Poster presentation
97
CYTOTOXIC ACTIVITY OF SESQUITERPENE LACTONE
BRITANIN FROM Inula britannica
D.E. Dusmatova, R.F. Mukhamatkhanova, I.D. Sham’yanov,
E.O. Terenteva, Sh.S. Azimova
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
e-mail:
rfm8@yandex.ru
The britanin is a chemotaxonomic marker for the plant
Inula britannica
. Britanin has
anti-inflammatory, anti-allergic activity [1], is a promising candidate for chemotherapy
of stomach cancer (BGC-823) [2], blocks the growth of
cell lines of breast cancer
(MCF-7, MDA-MB-468) [3], human tumor cell lines RD (rhabdomyosarcoma), MCF7
(adenocarcinoma breast) and MS (melanoma) [4], inhibits topoisomerase II and cancer
cell lines A549, HepG-2 and HT-29 [5] and has the potential effect of pancreatic cancer
treatment [6].
Britanin was isolated from the aerial part of
Inula britannica
,
growing in the
Tashkent region of the Republic of Uzbekistan.
Cytotoxic activity of britanin
in vitro
in relation to cervical cancer (HeLa) and
laryngeal adenocarcinoma (HEp-2) cells has been studied. In concentrations of 1 μg/ml,
britanin showed cell suppression at 19.4 0.5% (HeLa) and 2.8 0.8% (HEp-2) and in
concentrations of 10 μg/ml at 77.5 3.3% and 79.8 4.0%, respectively. Cisplatin was
used as a reference drug, with 81.6 3.9% (HeLa) and 52.8 3.6% (HEp-2) and 95.0 5.0%
and 89.2.2% at 10 μg/ml, respectively.
Thus, britanin has high cytotoxic activity with regard to cervical cancer cells (HeLa)
and laryngeal adenocarcinoma (HEp-2).
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