Poster presentation
317
ON THE HYPOLIPIDEMIC EFFECT OF TOTAL EXTRACTIVE
PREPARATIONS CONTAINING FLAVONOIDS, TRITERPENE
GLYCOSIDES AND PHYTOECDYSTEROIDS ISOLATED FROM
Thermopsis alterniflora, Zygophyllum oxianum and Silene viridiflora
N.Kh. Yuldasheva
2
, D.A. Narbutaeva
1
, V.N. Syrov
1
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences
of the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
e-mail: narbutaeva83@list.ru
2) Tashkent Medecinal Academy, Farobiy 2, Uzbekistan,
e-mail: nigoray@inbox.ru
Currently, the idea of using various biologically active substances isolated from
plants for the prevention and treatment of hyperlipidemia and atherosclerosis is
becoming more widespread.
The aim of the present work was to study in an appropriate way the sum of
flavonoids from
Thermopsis alterniflora
, the sum of
triterpene glycosides from
Zygophyllum oxianum
and the sum of phytoecdysteroids from
Silene viridiflora
.
The experiments were carried out on male rats weighing 200-250 g, with
hyperlipidemia caused by triton WR-1339 (225 mg/kg, once, intraperitoneally). The test
substances were administered orally at doses of 5-50 mg/kg. The content of total
cholesterol and triglycerides in the blood serum of animals was determined by the
enzymocalorimetric method using Cypress diagnostics (Belgium) reagent kits on a
Secomam Basic biochemical analyzer (France).
In the course of the studies, it was
found that the amount of flavonoids isolated from
Thermopsis alterniflora
(apigenin,
luteolin, formononetin, etc.), from
Silene viridiflora
, the
amount of phytoecdysteroids
(ecdysterone, sileneosides A, D, polypodin B, etc.) and from
Zygophyllum oxianum
, the
amount of triterpene glycosides (zygofiloside E, etc.) have a significant hypolipidemic
effect. The amount of triterpene glycosides from
Z. oxianum
lowered the level of
cholesterol in the blood serum more pronouncedly (by 35.0%), the amount of
flavonoids from
Th. alterniflora
clearly showed a hypotriglyceridemic effect of 40.8%,
and the amount of phytoecdysteroids from
S. viridiflora
had
an approximately
equivalent effect in this regard (25.8-30.2%). The reference drug clofibrate under these
conditions lowered the level of cholesterol in the blood serum by 27.2%, and
triglycerides by 38.6%. The data obtained in experiments on rats on a significant lipid-
lowering activity of the studied substances were subsequently confirmed in rabbits with
experimental atherosclerosis caused by prolonged oral administration of cholesterol.
Thus, the considered total preparations of flavonoids, triterpene glycosides, and
phytoecdysteroids are of interest as potential drugs for the treatment of hyperlipidemia
and atherosclerosis.
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