Organizing co mmittee

ISOLATION AND CRYSTAL STRUCTURE OF 8α,14-
DIHYDROXY-11,13-DIHYDROMELAMPOLIDE 
K.M. Turdybekov
1
, A.S. Serik
1
, R.I. Jalmakhanbetova
2
, 
Y.M. Suleimen
3
, Kristofer Van Hecke
4 
 
1
 E.A. Buketov Karaganda University, st. University, 28, Karaganda, Republic of 
Kazakhstan 
2
 L.N. Gumilyov Eurasian National University, st. Satbaeva, 2, Nur-Sultan, Republic 
of Kazakhstan 
3 
Sh. Ualikhanov Kokshetau University, st. Temirbekova, 30, Kokshetau, Republic of 
Kazakhstan 
4
 XStruct, Department of Chemistry, Ghent University, Ghent B-9000, Belgium 
 
8α,14-Dihydroxygermacra-1(10)E,4E-dien-6β,7α,11βH-12,6-olide 
(8α,14-
Dihydroxy-11,13-dihydromelampolide)] (
1)
, C
15
H
23
O
4
, was isolated from the 
Artemisia 
sublessingiana 
[1,2]. Compounds 
1
was isolated from 
Artemisia
species for the first 
time.
 
To establish the spatial structure, an X-ray diffraction study 1 was carried out, the 
general view of which is shown in the figure. The configuration of the C6, C7, C8, and 
C11 chiral centers is correlated with that known in germacranolides [3]. The Fleck 
parameter was -0.04(7). 
According to the conformational analysis carried out in 1(10)Z,4E-germacranolides
(melampolides), the ten-membered 
ring 
A 
can 
take 
four 
main 
conformations: 
chair-chair 
type 
15
D
5
,
1
D
14 
(
а
), bath-bath type 
15
D
5
,
1
D
14
(