Organizing co mmittee

STUDY ON THE DITERPENOID ALKALOIDS OF Delphinium AND 
Aconitum GROWING IN CENTRAL ASIAN 
 
Bo-Zhao
a
, Wen-juan Xue
a
, Nurfida Ablajan
a
, Ah. Samanbay
a
, Jiang-yu 
Zhao
a
, S. A. Zairovich
b
, Sh. Sh. Sagdullaev
b
, and H. A. Aisa
a
* 
 
a
 State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource 
Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of 
Sciences, Urumqi 830011, China; 
b 
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of 
Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan 
 
Diterpenoid alkaloids, a group of structurally complex natural products displaying a 
wide range of interesting chemical properties and biological activities, were widely 
distributed in the genera of 
Aconitum
and 
Delphinium
, one of the characteristic 
resources in Central Asia. Four diterpenoid alkaloids, lappaconitine, 3-acetyaconitine, 
crassiculine A and guan-fu base A, have been used as medicaments in clinical for 
treatment pain and arrhythmia. The genera 
Aconitum
and 
Delphinium
, rich in 
diterpenoid alkaloids, are one of the characteristic resources in Central Asia. 
Relying on the Joint Laboratory for Preparation Technology and Quality Standards 
of Medicines which was jointly established by the Central Asian Drug Discovery and 
Development Center of the Chinese Academy of Sciences and the Institute of 
Chemistry of Plant Substances of Uzbekistan Academy of Sciences, the extraction, 
isolation, structure identification and biological activity screening of diterpenoid 
alkaloids from 
Aconitum
and 
Delphinium
growing in Central Asia were carried out, 
such as 
Aconitum barbatum var puberulum
, 
Delphinium pseudoaemulans
, 
Delphinium 
naviculare 
var
. lasiocarpum
, 
Delphinium aemulans, et al.
As a result, 207 diterpenoid alkaloids were isolated, 48 of which were new 
compounds and 1 was new skeleton compound. Some compounds were found to have 
good antiarrhythmic, cytotoxicity and antibacterial activities. 16 articles have been 
published in SCI journals such as Phytochemistry, Phytochemistry Letters and 
Chemistry of Natural Compounds. 2 patents have been applied for, including an 
international PCT patent. 3 PhD students and 1 master student have been trained. 
New diterpenoid alkaloids from 
A. barbatum var. puberulum