Organizing co mmittee

 
V. 58, Pр. 967-969. 
 
 

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Plenary presentation 
6 
CHEMICAL PROFILE AND BIOLOGICAL ACTIVITIES OF 
KAZAKHSTANI ARTEMISIA SPECIES 
Prof. Dr. Janar Jenis 
1
The Research Center for Medicinal plants, Al-Farabi Kazakh National University, 
050040, Almaty, Kazakhstan 
2 
Research Institute for Natural Products & Technology, Almaty 050046, Kazakhstan; 
[e-mail]
 
Artemisia 
species has a great economic and medicinal perspective due to the fact of 
the isolation of artemisinin, which is the main phytochemical of 
Artemisia annua
L. 
represented as antimalarial drug. This research encouraged researchers all over the 
world to study traditional plants with the purpose of finding new bioactive medicines. 
The 
Artemisia 
L. species are potential sources of unique and new natural products, new 
chemical structures and displaying diverse bioactivities, leading to development of safe 
and effective phytomedicines against prevailing diseases in Kazakhstan and Central 
Asia region. The genus is represented in Asia in Kazakhstan, with 81 
Artemisia 
species, 
19 of them endemic. According to the literature, among 260 
Artemisia 
species revealed, 
various classes of secondary metabolites were shown including lignans, 
sesquiterpenoids, flavonoids, coumarins, glycosides, caffeoylquinic acids, sterols, and 
polyacetylenes. Terpenes, particularly sesquiterpene lactones, which are typical 
for 
Artemisia
, are extremely diverse and plentiful, which exhibit a wide range of 
therapeutic effects: anticancer, antimalarial, anti-inammatory, immunomodulatory, 
antiulcerogenic, antibacterial, antifungal, and antiviral. Many species of 
Artemisia 
genus as 
A. rupestris
, 
A. frigida 
Willd., 
A. annua 
L., 
A. lavandulaefolia
DC. have been 
described in The Kazakh Herbal Medicine (2012), and widely used in TKM (Traditional 
Kazakh Medicine) for the treatments of influenza, liver diseases, diarrhea, wounds, 
beriberi, tuberculosis, nervous disorders, to regulate pressure, weaken the processes of 
joint swelling, as well as for headaches and toothaches.
In our team recent study, the aim to search promising, potential active 
Artemisia
species candidates, stimulating us to analyze PTP1B, α-glucosidase and BNA inhibition 
as well as antioxidant potentials of 
Artemisia
plant extracts in which mostly endemic 
species have not been explored their secondary metabolites and biological activities so 
far. The main result of study was that for the first time among all species 
A. 
scopaeformis
.
 A. albicerata
.
,
A. transiliensis
, 
A. schrenkiana
, 
A. nitrosa 
Weber and 
A. 
albida 
due to their special metabolites, showed has a high potential to α-glucosidase, 
PTP1B and BNA inhibition which associates with diabetes, obesity, and bacterial 
infections. Thus, our results would contribute to human health benefits of 
Artemisia
species, based on inhibition of enzyme inhibitions.
In general, phenolic contents were 
correlated with those of flavonoid and biological activities. The methanol extracts of 
these 
Artemisia
species exhibited considerable high antioxidant activity. The presence 
of phenolic compounds in our extracts should be the main cause of its high antioxidant 
power. However, it is necessary that the examination of details between different 
Artemisia
species in our research has shown that other species also good materials for 
the antioxidant functional natural source. 

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Plenary presentation
7