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Immunogenet. 2003;30:289-93. 
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Lambert AP, Gillespie KM, Thomson G, Cordell HJ, Todd JA, Gale EA, Bingley PJ. 
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class 


Section 4A - Study Objectives/Background and Significance (Phase 3 - 11/2010) 
Section 4A - Page 19 
 Registry 
Study
 
 
II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab 
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Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC, Colman PG, Harrison LC. 
The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human 
leukocyte antigen genotypes. Diab.Care 2008;31:1546-9. 
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Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Rewers M, Dabelea D. 
Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth with Type 1 
Diabetes. Diab.Care 2008 31:1392 – 1396. 
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Weets I, De Leeuw IH, Du Caju MV, Rooman R, Keymeulen B, Mathieu C, Nobels F, 
Rottiers R, Scheen A, Van Gaal L, Schuit FC, Van der Auwera B, Rui M, De Pauw P, 
Kaufman L, Gorus FK; Belgian Diabetes Registry. The incidence of type 1 diabetes in the 
age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: 
evidence for earlier disease manifestation. Diabetes Care 2002; 25:840-6
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Pundziute-Lycka A, Dahlquist G, Nystrom L, Arnqvist H, Bjork E, Blohme G, Bolinder J, 
Eriksson J, Eriksson JW, Sundkvist G, Ostman J, Swedish Childhood Diabetes Study. The 
Incidence of type 1 diabetes has not increased, but has shifted to a younger age-at-diagnosis 
in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002;45:783-91. 
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Karvonen, M., Pitkaniemi, J., and Tuomilehto, J. The onset age of Type 1 Diabetes in 
Finnish children has become younger. Diabetes Care 1999; 22, 1066-1070.   
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Gardner SG, Bingley PJ, Sawtell PA, Weeks S, Gale EA. Rising incidence of insulin 
dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. 
The Bart's-Oxford Study Group [see comments]. Brit.Med.J. 1997;315:713-7. 
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Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Dabelea D. Childhood 
growth and age at diagnosis with Type 1 diabetes in Colorado young people. Diabet Med 
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Quinn M, Fleischman A, Rosner B, Nigrin DJ, Wolfsdorf JI. Characteristics at diagnosis of 
type 1 diabetes in children younger than 6 years. J Pediatr 2006;148:366-71. 
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Colman PG, McNair PD, Gellert S, Kewming K, Schmidli RS, Steele CE, Harrison LC. 
Development of autoantibodies to islet antigens during childhood: implications for 
preclinical type 1 diabetes screening. Pediatr Diabetes 2002;3:144-8. 
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Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R¸ Yu L, Palmer JP
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Zimmet P, Turner R, McCarty D, Rowley M, Mackay I. Crucial points at diagnosis. Type 2 
diabetes or slow type 1 diabetes. Diab.Care 1999;22 Suppl 2:B59-B64. 


Section 4A - Study Objectives/Background and Significance (Phase 3 - 11/2010) 
Section 4A - Page 20 
 Registry 
Study
 
 
69.
 
Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Evidence for 
heterogeneous pathogenesis of insulin-treated diabetes in Black and White children. 

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